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Disease relevance of Peritoneum


High impact information on Peritoneum

  • Splenic B-1 cells express CD5 but not Lck and are not hyporesponsive; however, within the peritoneum, these B-1 cells are induced to express Lck and acquire a hyporesponsive phenotype [6].
  • However, mMCP-4 inactivation resulted in complete loss of chymotryptic activity in the peritoneum and in ear tissue, indicating that mMCP-4 is the main source of stored chymotrypsin-like protease activity at these sites [7].
  • Intraperitoneal and stereotaxic intracerebral injection of fibrillar beta-amyloid in CD36 null mice induced significantly less macrophage and microglial recruitment into the peritoneum and brain, respectively, than in wild-type mice [8].
  • After treatment, CD11c(+)/major histocompatibility complex type II(+) and CD11c(+)/B220(+) DC lineage cells were the only cell populations increased in the spleen, liver, peritoneum, and skin [9].
  • Preferential recruitment of Th1 cells into the peritoneum is also seen when cytokine response gene 2 (CRG-2)/interferon gamma-inducible protein 10 (IP-10) is used as the sole inflammatory stimulus [10].

Chemical compound and disease context of Peritoneum


Biological context of Peritoneum


Anatomical context of Peritoneum

  • Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice [21].
  • In vivo, the beta 2 integrin-dependent recruitment of leukocytes to the inflamed peritoneum of uPAR-deficient mice was significantly reduced as compared with wild-type animals [22].
  • Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes [23].
  • The presence of antigen in the peritoneum promotes local proliferation of recruited T cells, and significantly amplifies the Th1 polarization of the lymphocytic infiltrate [10].
  • NK cell recruitment into the peritoneum was abrogated in TNF-deficient mice challenged with RMA-S or RM-1, a B6 MHC class I- prostate carcinoma, compared with B6 or perforin-deficient mice [24].

Associations of Peritoneum with chemical compounds

  • PGE2 was secreted into the culture media during in vitro growth, as well as into plasma during growth in the peritoneum of inbred C57BL/6 mice [25].
  • Canine, porcine, and bovine islets were seeded into tubular diffusion chambers and transplanted into the peritoneum of 27 nonimmunosuppressed streptozotocin-induced diabetic Lewis rats [26].
  • Cells, transiently expressing the Rluc were imaged while located in the peritoneum, s.c. layer, as well as in the liver and lungs of living mice tail-vein injected with coelenterazine [27].
  • Subsequently, the effect of NK-1RA administration on peritoneal fibrinolytic activity was investigated to determine a potential mechanism for SP action in the peritoneum [28].
  • PMN influx and degranulation in the peritoneum were reduced by 50% after 3 hours of treatment with 1 microgram of K562-IF (equivalent to the effect of 120 micrograms of prednisolone) [29].

Gene context of Peritoneum


Analytical, diagnostic and therapeutic context of Peritoneum


  1. Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury. Corada, M., Chimenti, S., Cera, M.R., Vinci, M., Salio, M., Fiordaliso, F., De Angelis, N., Villa, A., Bossi, M., Staszewsky, L.I., Vecchi, A., Parazzoli, D., Motoike, T., Latini, R., Dejana, E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3). Takatsuki, H., Komatsu, S., Sano, R., Takada, Y., Tsuji, T. Cancer Res. (2004) [Pubmed]
  3. Fibronectin secretion from human peritoneal tissue induces Mr 92,000 type IV collagenase expression and invasion in ovarian cancer cell lines. Shibata, K., Kikkawa, F., Nawa, A., Suganuma, N., Hamaguchi, M. Cancer Res. (1997) [Pubmed]
  4. Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Dabrosin, C., Gyorffy, S., Margetts, P., Ross, C., Gauldie, J. Am. J. Pathol. (2002) [Pubmed]
  5. Hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. Talmadge, J.E., Herberman, R.B., Chirigos, M.A., Maluish, A.E., Schneider, M.A., Adams, J.S., Philips, H., Thurman, G.B., Varesio, L., Long, C. J. Immunol. (1985) [Pubmed]
  6. Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck. Dal Porto, J.M., Burke, K., Cambier, J.C. Immunity (2004) [Pubmed]
  7. The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. Tchougounova, E., Pejler, G., Abrink, M. J. Exp. Med. (2003) [Pubmed]
  8. CD36 mediates the innate host response to beta-amyloid. El Khoury, J.B., Moore, K.J., Means, T.K., Leung, J., Terada, K., Toft, M., Freeman, M.W., Luster, A.D. J. Exp. Med. (2003) [Pubmed]
  9. Flt3 ligand-treated neonatal mice have increased innate immunity against intracellular pathogens and efficiently control virus infections. Vollstedt, S., Franchini, M., Hefti, H.P., Odermatt, B., O'Keeffe, M., Alber, G., Glanzmann, B., Riesen, M., Ackermann, M., Suter, M. J. Exp. Med. (2003) [Pubmed]
  10. Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells. Xie, H., Lim, Y.C., Luscinskas, F.W., Lichtman, A.H. J. Exp. Med. (1999) [Pubmed]
  11. Combination therapy: a way to limit emergence of resistance? Michéa-Hamzehpour, M., Pechère, J.C., Marchou, B., Auckenthaler, R. Am. J. Med. (1986) [Pubmed]
  12. Lectinophagocytosis of type 1 fimbriated (mannose-specific) Escherichia coli in the mouse peritoneum. Bernhard, W., Gbarah, A., Sharon, N. J. Leukoc. Biol. (1992) [Pubmed]
  13. Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites. Hirche, T.O., Atkinson, J.J., Bahr, S., Belaaouaj, A. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  14. Carboplatin plus paclitaxel in the treatment of gynecologic malignancies: the Cleveland Clinic experience. Markman, M., Kennedy, A., Webster, K., Kulp, B., Peterson, G., Belinson, J. Semin. Oncol. (1997) [Pubmed]
  15. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Griswold, D.E., Marshall, P.J., Webb, E.F., Godfrey, R., Newton, J., DiMartino, M.J., Sarau, H.M., Gleason, J.G., Poste, G., Hanna, N. Biochem. Pharmacol. (1987) [Pubmed]
  16. Peritoneal fibrinolytic activity and intra-abdominal adhesions. Vipond, M.N., Whawell, S.A., Thompson, J.N., Dudley, H.A. Lancet (1990) [Pubmed]
  17. A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo. Vlasenko, L.P., Melendez, A.J. J. Immunol. (2005) [Pubmed]
  18. CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. Bohlson, S.S., Silva, R., Fonseca, M.I., Tenner, A.J. J. Immunol. (2005) [Pubmed]
  19. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. Barton, E.S., Lutzke, M.L., Rochford, R., Virgin, H.W. J. Virol. (2005) [Pubmed]
  20. Effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum. van Rossen, M.E., Hofland, L.J., van den Tol, M.P., van Koetsveld, P.M., Jeekel, J., Marquet, R.L., van Eijck, C.H. J. Pathol. (2001) [Pubmed]
  21. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. Mizgerd, J.P., Kubo, H., Kutkoski, G.J., Bhagwan, S.D., Scharffetter-Kochanek, K., Beaudet, A.L., Doerschuk, C.M. J. Exp. Med. (1997) [Pubmed]
  22. Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo. May, A.E., Kanse, S.M., Lund, L.R., Gisler, R.H., Imhof, B.A., Preissner, K.T. J. Exp. Med. (1998) [Pubmed]
  23. Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. Mercolino, T.J., Arnold, L.W., Hawkins, L.A., Haughton, G. J. Exp. Med. (1988) [Pubmed]
  24. An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum. Smyth, M.J., Kelly, J.M., Baxter, A.G., Körner, H., Sedgwick, J.D. J. Exp. Med. (1998) [Pubmed]
  25. Prostaglandin E2 production by EL 4 leukemia cells from C57BL/6 mice: mechanism for tumor dissemination. Mahan, M., Meunier, J., Newby, M., Young, M.R. J. Natl. Cancer Inst. (1985) [Pubmed]
  26. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Lanza, R.P., Butler, D.H., Borland, K.M., Staruk, J.E., Faustman, D.L., Solomon, B.A., Muller, T.E., Rupp, R.G., Maki, T., Monaco, A.P. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  27. Optical imaging of Renilla luciferase reporter gene expression in living mice. Bhaumik, S., Gambhir, S.S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  28. A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Reed, K.L., Fruin, A.B., Gower, A.C., Stucchi, A.F., Leeman, S.E., Becker, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  29. K562 cells produce an anti-inflammatory factor that inhibits neutrophil functions in vivo. Amar, M., Amit, N., Scoazec, J.Y., Pasquier, C., Babin-Chevaye, C., Huu, T.P., Hakim, J. Blood (1992) [Pubmed]
  30. Molecular evidence for multifocal papillary serous carcinoma of the peritoneum in patients with germline BRCA1 mutations. Schorge, J.O., Muto, M.G., Welch, W.R., Bandera, C.A., Rubin, S.C., Bell, D.A., Berkowitz, R.S., Mok, S.C. J. Natl. Cancer Inst. (1998) [Pubmed]
  31. Cancer risks for male carriers of germline mutations in BRCA1 or BRCA2: a review of the literature. Liede, A., Karlan, B.Y., Narod, S.A. J. Clin. Oncol. (2004) [Pubmed]
  32. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. Matsukawa, A., Hogaboam, C.M., Lukacs, N.W., Lincoln, P.M., Strieter, R.M., Kunkel, S.L. J. Immunol. (1999) [Pubmed]
  33. Experimental manipulation of transforming growth factor-beta isoforms significantly affects adhesion formation in a murine surgical model. Gorvy, D.A., Herrick, S.E., Shah, M., Ferguson, M.W. Am. J. Pathol. (2005) [Pubmed]
  34. T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells. Rizza, P., Santini, S.M., Logozzi, M.A., Lapenta, C., Sestili, P., Gherardi, G., Lande, R., Spada, M., Parlato, S., Belardelli, F., Fais, S. J. Virol. (1996) [Pubmed]
  35. Combination chemotherapy with carboplatin and docetaxel in the treatment of cancers of the ovary and fallopian tube and primary carcinoma of the peritoneum. Markman, M., Kennedy, A., Webster, K., Peterson, G., Kulp, B., Belinson, J. J. Clin. Oncol. (2001) [Pubmed]
  36. ME1. A monoclonal antibody that distinguishes epithelial-type malignant mesothelioma from pulmonary adenocarcinoma and extrapulmonary malignancies. O'Hara, C.J., Corson, J.M., Pinkus, G.S., Stahel, R.A. Am. J. Pathol. (1990) [Pubmed]
  37. Increasing peritoneal contact area during dialysis improves mass transfer. Flessner, M.F., Lofthouse, J., Williams, A. J. Am. Soc. Nephrol. (2001) [Pubmed]
  38. Pyridoxal phosphate and hepatocyte growth factor prevent dialysate-induced peritoneal damage. Nakamura, S., Niwa, T. J. Am. Soc. Nephrol. (2005) [Pubmed]
  39. Evidence for survival and metabolic activity of encapsulated xenogeneic hepatocytes transplanted without immunosuppression in Gunn rats. Gomez, N., Balladur, P., Calmus, Y., Baudrimont, M., Honiger, J., Delelo, R., Myara, A., Crema, E., Trivin, F., Capeau, J., Nordlinger, B. Transplantation (1997) [Pubmed]
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