Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Clavulanate (2R,3Z,5R)-3-(2- hydroxyethylidene)-7-oxo-4...

Synonyms: Clavulox, Clavulansaeure, CHEMBL777, BRL-14151, MM-14151, ...

Navon-Venezia, S. et al., McLigeyo, n.u.l.l. et al., Shen, Y. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CLAVULANIC ACID

We found a high proportion of Escherichia coli resistant to ampicillin (46%) but not to amoxycillin/clavulinic acid [1].
Amoxicillin plus clavulinic acid (Augmentin) and Clindamycin were the best antimicrobial combinations in cases where the ulcers had some acute features (e.g. surrounding cellulitis) [2].

High impact information on CLAVULANIC ACID

A difference of > or =5 mm in the size of the zone of inhibition in the presence of CLAV for at least one of the agents was considered representative of the ESBL phenotype: 186 isolates (42.5%) were confirmed as ESBL producers [3].

References

Renal imaging in pyelonephritis. Shen, Y., Brown, M.A. Nephrology (Carlton, Vic.) (2004) [Pubmed]
Diabetic ulcers--a clinical and bacteriological study. McLigeyo, n.u.l.l., Oumah, S., Otieno, n.u.l.l., Saul, L. West African journal of medicine. (1990) [Pubmed]
Occurrence and phenotypic characteristics of extended-spectrum beta-lactamases among members of the family Enterobacteriaceae at the Tel-Aviv Medical Center (Israel) and evaluation of diagnostic tests. Navon-Venezia, S., Hammer-Munz, O., Schwartz, D., Turner, D., Kuzmenko, B., Carmeli, Y. J. Clin. Microbiol. (2003) [Pubmed]

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