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Chemical Compound Review

Augmentin     potassium;(2S,5R,6R)-6- [[(2R)-2-amino-2...

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Disease relevance of Augmentin


Psychiatry related information on Augmentin


High impact information on Augmentin


Chemical compound and disease context of Augmentin


Biological context of Augmentin


Anatomical context of Augmentin

  • Lung secretions from patients with bronchiectasis have been studied before and during treatment with amoxycillin/clavulanate (Augmentin 750 mg tds). beta-Lactamase activity was usually present in the sputum sol phase and originated from organisms not usually considered to be the major pathogen [22].
  • A new beta-lactamase-stable oral antibiotic (Augmentin) has been found to be effective in the treatment of urinary tract infections (uncomplicated and complicated, recurrent, and nosocomial) and bacteriuria [23].
  • Microbial and clinical features of 2-to-3 wall periodontal bony defects treated with membranes with and without concomitant use of systemic Augmentin therapy were also determined [24].
  • We would recommend 3 days of additional oral Augmentin after a single dose of intravenous antibiotics in patients at increased risk of sepsis, which would include those with bile duct stones and/or those undergoing a therapeutic procedure [25].
  • An investigation into the effect of traumatically produced cerebrospinal fluid fistulae on the passage of Augmentin across the blood-brain barrier [26].

Associations of Augmentin with other chemical compounds


Gene context of Augmentin


Analytical, diagnostic and therapeutic context of Augmentin


  1. Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. Engelhard, D., Cohen, D., Strauss, N., Sacks, T.G., Jorczak-Sarni, L., Shapiro, M. Lancet (1989) [Pubmed]
  2. Amoxicillin-clavulanic acid in the treatment of lower respiratory tract infections caused by beta-lactamase-positive Haemophilus influenzae and Branhamella catarrhalis. Wallace, R.J., Steele, L.C., Brooks, D.L., Luman, J.I., Wilson, R.W., McLarty, J.W. Antimicrob. Agents Chemother. (1985) [Pubmed]
  3. In vitro evaluation of Augmentin by broth microdilution and disk diffusion susceptibility testing: regression analysis, tentative interpretive criteria, and quality control limits. Fuchs, P.C., Barry, A.L., Thornsberry, C., Gavan, T.L., Jones, R.N. Antimicrob. Agents Chemother. (1983) [Pubmed]
  4. Intravenous Augmentin in bacteraemia and severe invasive polymicrobial sepsis. Mehtar, S., Ball, A.P. J. Antimicrob. Chemother. (1985) [Pubmed]
  5. Comparative treatment trial of augmentin versus cefaclor for acute otitis media with effusion. Odio, C.M., Kusmiesz, H., Shelton, S., Nelson, J.D. Pediatrics (1985) [Pubmed]
  6. Prophylactic augmentin in prelabor preterm rupture of the membranes. Magwali, T.L., Chipato, T., Majoko, F., Rusakaniko, S., Mujaji, C. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (1999) [Pubmed]
  7. Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic study. Czeizel, A.E., Rockenbauer, M., Sørensen, H.T., Olsen, J. Eur. J. Obstet. Gynecol. Reprod. Biol. (2001) [Pubmed]
  8. Pathological and therapeutic significance of cellular invasion by Proteus mirabilis in an enterocystoplasty infection stone model. Mathoera, R.B., Kok, D.J., Verduin, C.M., Nijman, R.J. Infect. Immun. (2002) [Pubmed]
  9. Cholestatic hepatitis due to an amoxycillin/clavulanic acid preparation. Verhamme, M., Ramboer, C., Van de Bruaene, P., Inderadjaja, N. J. Hepatol. (1989) [Pubmed]
  10. Beta-lactam resistance in Nocardia brasiliensis is mediated by beta-lactamase and reversed in the presence of clavulanic acid. Wallace, R.J., Nash, D.R., Johnson, W.K., Steele, L.C., Steingrube, V.A. J. Infect. Dis. (1987) [Pubmed]
  11. Assay of amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with high-performance liquid chromatography. Foulstone, M., Reading, C. Antimicrob. Agents Chemother. (1982) [Pubmed]
  12. Pharmacokinetics of a syrup formulation of amoxycillin-potassium clavulanate in children. Schaad, U.B., Casey, P.A., Ravenscroft, A.T. J. Antimicrob. Chemother. (1986) [Pubmed]
  13. Augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent. White, A.R., Kaye, C., Poupard, J., Pypstra, R., Woodnutt, G., Wynne, B. J. Antimicrob. Chemother. (2004) [Pubmed]
  14. Metronidazole and Augmentin in the prevention of sepsis after appendicectomy. Drumm, J., Donovan, I.A., Wise, R., Lowe, P. The British journal of surgery. (1985) [Pubmed]
  15. Phage pattern-specific oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus in U.S. hospitals: epidemiological significance. Zierdt, C.H., Hosein, I.K., Shively, R., MacLowry, J.D. J. Clin. Microbiol. (1992) [Pubmed]
  16. A comparison between amoxycillin/clavulanate and mezlocillin in abdominal surgical prophylaxis. Menzies, D., Gilbert, J.M., Shepherd, M.J., Rogers, T.R. J. Antimicrob. Chemother. (1989) [Pubmed]
  17. Uncovering a Rare but Critical Complication Following Thyroid Surgery: An Audit Across the UK and Ireland. Hardy, R.G., Forsythe, J.L. Thyroid (2007) [Pubmed]
  18. Penetration of augmentin and timentin into lymph after simulation of human serum pharmacokinetics in the rabbit. Woodnutt, G., Kernutt, I., Mizen, L. Journal of chemotherapy (Florence, Italy) (1989) [Pubmed]
  19. Divergent disk susceptibility of coagulase-negative staphylococci to penicillinase-resistant penicillins and augmentin (amoxycillin/clavulanic acid). Traub, W.H. Chemotherapy. (1985) [Pubmed]
  20. Epidemiology of beta-lactamase production and possibilities for the use of augmentin. Varaldo, P.E., Maida, A., Nicoletti, G., Schito, G.C. Journal of chemotherapy (Florence, Italy) (1989) [Pubmed]
  21. Augmentin-induced jaundice with a fatal outcome. Hebbard, G.S., Smith, K.G., Gibson, P.R., Bhathal, P.S. Med. J. Aust. (1992) [Pubmed]
  22. Role of beta-lactamases in the response of pulmonary infections to amoxycillin/clavulanate. Stockley, R.A., Dragicevic, P., Burnett, D., Hill, S.L. J. Antimicrob. Chemother. (1989) [Pubmed]
  23. Amoxicillin/clavulanate in urinary tract infection. Gasser, T.C., Larsen, E.H., Madsen, P.O. Urology (1987) [Pubmed]
  24. Periodontal pathogens on polytetrafluoroethylene membrane for guided tissue regeneration inhibit healing. Nowzari, H., Matian, F., Slots, J. Journal of clinical periodontology. (1995) [Pubmed]
  25. Preventing endoscopic retrograde cholangiopancreatography related sepsis: a randomized controlled trial comparing two antibiotic regimes. Smith, B.C., Alqamish, J.R., Watson, K.J., Shaw, R.G., Andrew, J.H., Desmond, P.V. J. Gastroenterol. Hepatol. (1996) [Pubmed]
  26. An investigation into the effect of traumatically produced cerebrospinal fluid fistulae on the passage of Augmentin across the blood-brain barrier. Lyons, A.J. The British journal of oral & maxillofacial surgery. (1990) [Pubmed]
  27. Efficacy of ofloxacin and other otic preparations for acute otitis media in patients with tympanostomy tubes. Goldblatt, E.L. Pediatr. Infect. Dis. J. (2001) [Pubmed]
  28. Augmentin (amoxycillin-clavulanic acid) compared with amoxycillin alone in the treatment of urinary tract infections in the elderly. Gallacher, G., Erwin, L., Scott, P.J., Sleigh, J.D. J. Infect. (1986) [Pubmed]
  29. An in vitro characterization of cefditoren, a new oral cephalosporin. Felmingham, D., Robbins, M.J., Ghosh, G., Bhogal, H., Mehta, M.D., Leakey, A., Clark, S., Dencer, C.A., Ridgway, G.L., Grüneberg, R.N. Drugs under experimental and clinical research. (1994) [Pubmed]
  30. Response to periodontal therapy in patients with high or low levels of P. gingivalis, P. intermedia, P. nigrescens and B. forsythus. Haffajee, A.D., Socransky, S.S., Dibart, S., Kent, R.L. Journal of clinical periodontology. (1996) [Pubmed]
  31. Comparative study of augmentin versus metronidazole/gentamicin in the prevention of infections after appendicectomy. al-Dhohayan, A., al-Sebayl, M., Shibl, A., al-Eshalwy, S., Kattan, K., al-Saleh, M. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1993) [Pubmed]
  32. Positive direct antiglobulin tests and haemolytic anaemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Garratty, G., Arndt, P.A. Br. J. Haematol. (1998) [Pubmed]
  33. Activity of amoxycillin/clavulanic acid (augmentin) against beta-lactamase-positive S. aureus, H. influenzae and B. catarrhalis in an in vitro kinetic model. Cooper, C.E., Slocombe, B., White, A.R. Journal of chemotherapy (Florence, Italy) (1989) [Pubmed]
  34. Sensitivity of clinical isolates from German hospitals to amoxicillin/clavulanic acid (Augmentin) compared with other antibiotics. Focht, J., Klietmann, W., Nösner, K., Rolinson, G.N., Johnsen, J. Chemotherapy. (1988) [Pubmed]
  35. Augmentin compared with amoxycillin in treating uncomplicated gonorrhoea. Key, P.R., Azadian, B.S., Evans, B.A. Genitourinary medicine. (1985) [Pubmed]
  36. Amoxycillin-clavulanic acid (Augmentin) antibiotic prophylaxis against wound infections in renal failure patients. Evans, C.M., Purohit, S., Colbert, J.W., Lear, P.A., Makin, T., Scobie, D.J., Williamson, E.P., Sells, R.A. J. Antimicrob. Chemother. (1988) [Pubmed]
  37. A study on prophylactic antibiotics in cesarean sections--is it worthwhile? Yip, S.K., Lau, T.K., Rogers, M.S. Acta obstetricia et gynecologica Scandinavica. (1997) [Pubmed]
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