Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Scutellarein 5,6,7-trihydroxy-2-(4- hydroxyphenyl)chrome...

Synonyms: Isocarthamidin, CHEMBL55415, AC1NQYX1, CHEBI:9062, CPD-12726, ...

Zhou, J. et al., Huang, J.M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Isocarthamidin

RESULTS: The pathologic changes in the left ventricle in the Scutellarein group rats (SHR(D)) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction [1].

High impact information on Isocarthamidin

The relative bioavailability of oral administration was very low, 10.67 % +/- 4.78% for scutellarin and 7.92% +/- 1.90% for scutellarein conjugates [2].
Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats [1].
OBJECTIVE: To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs) [1].

Anatomical context of Isocarthamidin

CONCLUSION: Scutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle [1].

Analytical, diagnostic and therapeutic context of Isocarthamidin

Scutellarein and saline (10 mg x kg(-1) x d(-1)) were given by intraperitoneal injection to two groups of rats separately [1].

References

Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats. Zhou, J., Lei, H., Chen, Y., Li, F., Ma, C. Chin. Med. J. (2002) [Pubmed]
Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats. Huang, J.M., Weng, W.Y., Huang, X.B., Ji, Y.H., Chen, E. European journal of drug metabolism and pharmacokinetics. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg