Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NQZYD (8S,9S,10R,13S,14S,17S)-17- hydroxy-10,13...

Synonyms: SureCN142253, C14256, 564-35-2, 1050679-19-0, 11-Oxotestosterone, ...

Remage-Healey, L. et al., Musharraf, S.G. et al., Yeoh, C.G. et al., Onuma, T. et al., Todo, T. et al.

Onuma, Ando, Koide, Okada, Urano,

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High impact information on C14256

Electrophysiological experiments revealed that intramuscular injections of either 11kT or cortisol, but neither testosterone nor 17-beta-estradiol, induced increases within 5 min in the output of the vocal pattern generator in males, whereas only cortisol had similarly fast effects in females [1].
These results indicate that the cloned cDNA encodes a functional eel AR, and its major native ligand is 11KT [2].
In the females, E2 and 11KT increased the amounts of PRL and SL mRNAs in the pre-spawning stage, but halved those of PRL mRNA in the spawning stage [3].
Two days after hatch, 11-ketotestosterone (11KT) increased in concentrations in both gynogenetic and bisexual populations, and 11KT glucuronide concentrations increased in the gynogenetic population [4].
The microbial transformation of (+)-adrenosterone (1) by Cephalosporium aphidicola afforded three metabolites identified as androsta-1,4-diene-3,11,17-trione (2), 17beta-hydroxyandrost-4-ene-3,11-dione (3) and 17beta-hydroxyandrosta-1,4-diene-3,11-dione (4) [5].

References

From social behavior to neural circuitry: steroid hormones rapidly modulate advertisement calling via a vocal pattern generator. Remage-Healey, L., Bass, A.H. Hormones and behavior. (2006) [Pubmed]
Fish androgen receptor: cDNA cloning, steroid activation of transcription in transfected mammalian cells, and tissue mRNA levels. Todo, T., Ikeuchi, T., Kobayashi, T., Nagahama, Y. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
Effects of salmon GnRH and sex steroid hormones on expression of genes encoding growth hormone/prolactin/somatolactin family hormones and a pituitary-specific transcription factor in masu salmon pituitary cells in vitro. Onuma, T., Ando, H., Koide, N., Okada, H., Urano, A. Gen. Comp. Endocrinol. (2005) [Pubmed]
Endogenous steroid metabolism is indicated by fluctuations of endogenous steroid and steroid glucuronide levels in early development of the steelhead trout (Oncorhynchus mykiss). Yeoh, C.G., Schreck, C.B., Feist, G.W., Fitzpatrick, M.S. Gen. Comp. Endocrinol. (1996) [Pubmed]
Microbial transformation of (+)-adrenosterone. Musharraf, S.G., Atta-Ur-Rahman, n.u.l.l., Choudhary, M.I., Sultan, S. Natural product letters. (2002) [Pubmed]

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