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Chemical Compound Review

AC1NRAET     (3Z)-6-bromo-3-[3- (hydroxyamino)indol-2...

Synonyms: CHEMBL243555, CHEMBL409450, CHEMBL2178734, B1686_SIGMA, CHEBI:387773, ...
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High impact information on BRW


Anatomical context of BRW

  • First is shown that transient exposure of isolated kidney mesenchymes to structurally different glycogen synthase kinase-3 (GSK3) inhibitors lithium or 6-bromoindirubin-3'-oxime results in abundant epithelial differentiation and full segregation of nephrons [4].


  1. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., Brivanlou, A.H. Nat. Med. (2004) [Pubmed]
  2. The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Tseng, A.S., Engel, F.B., Keating, M.T. Chem. Biol. (2006) [Pubmed]
  3. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Meijer, L., Skaltsounis, A.L., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., Ryan, X.P., Vonica, C.A., Brivanlou, A., Dajani, R., Crovace, C., Tarricone, C., Musacchio, A., Roe, S.M., Pearl, L., Greengard, P. Chem. Biol. (2003) [Pubmed]
  4. Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes. Kuure, S., Popsueva, A., Jakobson, M., Sainio, K., Sariola, H. J. Am. Soc. Nephrol. (2007) [Pubmed]
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