Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NRAET (3Z)-6-bromo-3-[3- (hydroxyamino)indol-2...

Synonyms: CHEMBL243555, CHEMBL409450, CHEMBL2178734, B1686_SIGMA, CHEBI:387773, ...

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High impact information on BRW

Instead we find that Wnt pathway activation by 6-bromoindirubin-3'-oxime (BIO), a specific pharmacological inhibitor of glycogen synthase kinase-3 (GSK-3), maintains the undifferentiated phenotype in both types of ESCs and sustains expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog [1].
Interestingly, the small molecule 6-bromoindirubin-3'-oxime (BIO) is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells [2].
Among these, the new natural product 6-bromoindirubin and its synthetic, cell-permeable derivative, 6-bromoindirubin-3'-oxime (BIO), display remarkable selective inhibition of glycogen synthase kinase-3 (GSK-3) [3].

Anatomical context of BRW

First is shown that transient exposure of isolated kidney mesenchymes to structurally different glycogen synthase kinase-3 (GSK3) inhibitors lithium or 6-bromoindirubin-3'-oxime results in abundant epithelial differentiation and full segregation of nephrons [4].

References

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., Brivanlou, A.H. Nat. Med. (2004) [Pubmed]
The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Tseng, A.S., Engel, F.B., Keating, M.T. Chem. Biol. (2006) [Pubmed]
GSK-3-selective inhibitors derived from Tyrian purple indirubins. Meijer, L., Skaltsounis, A.L., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., Ryan, X.P., Vonica, C.A., Brivanlou, A., Dajani, R., Crovace, C., Tarricone, C., Musacchio, A., Roe, S.M., Pearl, L., Greengard, P. Chem. Biol. (2003) [Pubmed]
Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes. Kuure, S., Popsueva, A., Jakobson, M., Sainio, K., Sariola, H. J. Am. Soc. Nephrol. (2007) [Pubmed]

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