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Gene Review

Zfp42  -  zinc finger protein 42

Mus musculus

Synonyms: REX-1, Reduced expression protein 1, Rex-1, Rex1, Zfp-42, ...
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Disease relevance of Zfp42


High impact information on Zfp42


Chemical compound and disease context of Zfp42


Biological context of Zfp42

  • Human Rex-1 (hRex-1) (also referred to as zinc-finger protein-42, Zfp42) encodes a zinc finger protein expression of which is believed to be characteristic of pluripotent stem cells [12].
  • Rex-1 reporter plasmids including this octamer site also exhibited reduced expression in F9 cells treated with RA [11].
  • The putative REX-1 protein identified by DNA sequence analysis contains four repeats of the zinc finger nucleic acid-binding motif and a potential acidic activator domain, suggesting that REX-1 encodes a regulatory protein [2].
  • A region required for Rex-1 promoter activity in F9 stem cells contains an octamer motif (ATTTGCAT) which is a binding site for octamer transcription factor members of the POU domain family of DNA-binding proteins [11].
  • As an initial confirmation of the in vivo relevance of the isolated fragment, a larger Rex-1 promoter fragment, also containing the octamer site, was able to promote expression of the bacterial lacZ gene in mouse embryos at the morula stage [11].

Anatomical context of Zfp42

  • Detailed mapping of these genes with Oct4, Rex1 and Fgf5 on pregastrulation embryos provided the first molecular evidence for the existence of successive, temporally distinct pluripotent cell populations in the embryo between the ICM and primitive ectoderm [13].
  • RNAi knockdown of Zfp42 induced ES cells differentiate to endoderm and mesoderm lineages, and overexpression of Zfp42 also caused ES cells to lose the capacity of self-renewal [14].
  • The fact that these CD34+ cells also express transcription factors (Rex-1 and Oct-4) that are found in early development elicits the hypothesis that they may be pluripotent embryonic-like stem cells [15].
  • The only tested adult tissue that contains detectable amounts of Rex-1 mRNA is the testis [16].
  • As expected for a stem-cell-specific message, Rex-1 mRNA is present in the inner cell mass (ICM) of the day 4.5 mouse blastocyst [16].

Associations of Zfp42 with chemical compounds


Physical interactions of Zfp42

  • The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells [1].

Other interactions of Zfp42


Analytical, diagnostic and therapeutic context of Zfp42


  1. The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. Rosfjord, E., Rizzino, A. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  2. Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Hosler, B.A., LaRosa, G.J., Grippo, J.F., Gudas, L.J. Mol. Cell. Biol. (1989) [Pubmed]
  3. Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice. Lerner, D.L., Yamada, K.A., Schuessler, R.B., Saffitz, J.E. Circulation (2000) [Pubmed]
  4. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Leone, A., Flatow, U., King, C.R., Sandeen, M.A., Margulies, I.M., Liotta, L.A., Steeg, P.S. Cell (1991) [Pubmed]
  5. Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes. Wood, W.M., Kao, M.Y., Gordon, D.F., Ridgway, E.C. J. Biol. Chem. (1989) [Pubmed]
  6. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Perl, A.K., Dahl, U., Wilgenbus, P., Cremer, H., Semb, H., Christofori, G. Nat. Med. (1999) [Pubmed]
  7. The met proto-oncogene receptor and lumen formation. Tsarfaty, I., Resau, J.H., Rulong, S., Keydar, I., Faletto, D.L., Vande Woude, G.F. Science (1992) [Pubmed]
  8. Selective disruption of genes expressed in totipotent embryonal stem cells. von Melchner, H., DeGregori, J.V., Rayburn, H., Reddy, S., Friedel, C., Ruley, H.E. Genes Dev. (1992) [Pubmed]
  9. Surface properties of bacillus Calmette-Guérin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia. Ezekowitz, R.A., Austyn, J., Stahl, P.D., Gordon, S. J. Exp. Med. (1981) [Pubmed]
  10. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Mauvais-Jarvis, F., Ueki, K., Fruman, D.A., Hirshman, M.F., Sakamoto, K., Goodyear, L.J., Iannacone, M., Accili, D., Cantley, L.C., Kahn, C.R. J. Clin. Invest. (2002) [Pubmed]
  11. An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells. Hosler, B.A., Rogers, M.B., Kozak, C.A., Gudas, L.J. Mol. Cell. Biol. (1993) [Pubmed]
  12. The putative human stem cell marker, Rex-1 (Zfp42): Structural classification and expression in normal human epithelial and carcinoma cell cultures. Mongan, N.P., Martin, K.M., Gudas, L.J. Mol. Carcinog. (2006) [Pubmed]
  13. Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. Pelton, T.A., Sharma, S., Schulz, T.C., Rathjen, J., Rathjen, P.D. J. Cell. Sci. (2002) [Pubmed]
  14. Screening for genes essential for mouse embryonic stem cell self-renewal using a subtractive RNA interference library. Zhang, J.Z., Gao, W., Yang, H.B., Zhang, B., Zhu, Z.Y., Xue, Y.F. Stem Cells (2006) [Pubmed]
  15. Hematopoietic progenitors express neural genes. Goolsby, J., Marty, M.C., Heletz, D., Chiappelli, J., Tashko, G., Yarnell, D., Fishman, P.S., Dhib-Jalbut, S., Bever, C.T., Pessac, B., Trisler, D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes. Rogers, M.B., Hosler, B.A., Gudas, L.J. Development (1991) [Pubmed]
  17. Reduced expression of (alpha)5(beta)1 integrin prevents spreading-dependent cell proliferation. Davey, G., Buzzai, M., Assoian, R.K. J. Cell. Sci. (1999) [Pubmed]
  18. Two distinct steps of Bak regulation during apoptotic stress signaling: Different roles of MEKK1 and JNK1. Ihrlund, L.S., Hernlund, E., Viktorsson, K., Panaretakis, T., Barna, G., Sabapathy, K., Linder, S., Shoshan, M.C. Exp. Cell Res. (2006) [Pubmed]
  19. Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo. Chernicky, C.L., Tan, H., Yi, L., Loret de Mola, J.R., Ilan, J. MP, Mol. Pathol. (2002) [Pubmed]
  20. Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cells. Scemes, E., Duval, N., Meda, P. J. Neurosci. (2003) [Pubmed]
  21. Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene. Thompson, J.R., Gudas, L.J. Mol. Cell. Endocrinol. (2002) [Pubmed]
  22. Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading. Sakuma-Zenke, M., Sakai, A., Nakayamada, S., Kunugita, N., Tabata, T., Uchida, S., Tanaka, S., Mori, T., Nakai, K., Tanaka, Y., Nakamura, T. J. Bone Miner. Res. (2005) [Pubmed]
  23. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Raman, J.D., Mongan, N.P., Liu, L., Tickoo, S.K., Nanus, D.M., Scherr, D.S., Gudas, L.J. Carcinogenesis (2006) [Pubmed]
  24. Chronic rejection of mouse kidney allografts. Mannon, R.B., Kopp, J.B., Ruiz, P., Griffiths, R., Bustos, M., Platt, J.L., Klotman, P.E., Coffman, T.M. Kidney Int. (1999) [Pubmed]
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