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Gene Review

gsk3a  -  glycogen synthase kinase 3 alpha

Xenopus laevis

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High impact information on LOC398338


Biological context of LOC398338


Anatomical context of LOC398338

  • GSK-3 phosphorylates several transcription factors, and we have recently shown that it modifies the major nuclear pore protein p62 [6].
  • Because neither glycogen nor GSK-3 has been localized to the nuclear envelope or intranuclear sites, glycogen and GSK-3 activites were measured in rat liver nuclei and nuclear reformation extracts [6].

Associations of LOC398338 with chemical compounds


Other interactions of LOC398338


  1. Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Sarkissian, M., Mendez, R., Richter, J.D. Genes Dev. (2004) [Pubmed]
  2. Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. Farr, G.H., Ferkey, D.M., Yost, C., Pierce, S.B., Weaver, C., Kimelman, D. J. Cell Biol. (2000) [Pubmed]
  3. A novel role for glycogen synthase kinase-3 in Xenopus development: maintenance of oocyte cell cycle arrest by a beta-catenin-independent mechanism. Fisher, D.L., Morin, N., Dorée, M. Development (1999) [Pubmed]
  4. Identification of the Axin and Frat binding region of glycogen synthase kinase-3. Fraser, E., Young, N., Dajani, R., Franca-Koh, J., Ryves, J., Williams, R.S., Yeo, M., Webster, M.T., Richardson, C., Smalley, M.J., Pearl, L.H., Harwood, A., Dale, T.C. J. Biol. Chem. (2002) [Pubmed]
  5. Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish. Sumoy, L., Kiefer, J., Kimelman, D. Dev. Genes Evol. (1999) [Pubmed]
  6. Nuclear glycogen and glycogen synthase kinase 3. Ragano-Caracciolo, M., Berlin, W.K., Miller, M.W., Hanover, J.A. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  7. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Meijer, L., Skaltsounis, A.L., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., Ryan, X.P., Vonica, C.A., Brivanlou, A., Dajani, R., Crovace, C., Tarricone, C., Musacchio, A., Roe, S.M., Pearl, L., Greengard, P. Chem. Biol. (2003) [Pubmed]
  8. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Liao, G., Tao, Q., Kofron, M., Chen, J.S., Schloemer, A., Davis, R.J., Hsieh, J.C., Wylie, C., Heasman, J., Kuan, C.Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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