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Chemical Compound Review:

AC1NRDFA 3-[4-(4-fluorophenyl)-1,3- oxazol-5-yl]-9...

Synonyms: SureCN40860, CHEMBL194322, CHEBI:46220, DNC006794, CP-808844, ...

Guba, W. et al., Bryant, S.G. et al., Mann, J.J. et al., McClure, K.F. et al., Feighner, J.P.

McClure, Letavic, Kalgutkar, Gabel, Audoly, Barberia, Braganza, Carter, Carty, Cortina, Dombroski, Donahue, Elliott, Gibbons, Jordan, Kuperman, Labasi, Laliberte, McCoy, Naiman, Nelson, Nguyen, Peese, Sweeney, Taylor, Trebino, Abramov, Laird, Volberg, Zhou, Bach, Lombardo,

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Psychiatry related information on TRIAZOLOPYRIDINE

Trazodone, a triazolopyridine derivative, in primary depressive disorder [1].

High impact information on TRIAZOLOPYRIDINE

A 4-wk double-blind controlled study of the antidepressant efficacy of the triazolopyridine derivative trazodone, in contrast to imipramine and placebo, was carried out in 30 endogenously depressed outpatients [2].
Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development [3].
Based on the analysis of H-bond donor/acceptor capabilities of the isomeric triazolopyridine pairs it can be concluded that the H-bond donor strength of the free amino functionality is the main determinant for hA2a inhibitory activity and hA1 selectivity [4].
The chemistry, pharmacokinetics, biochemistry and pharmacology, clinical trials, adverse effects, FDA-approved indications, and availability and cost of trazodone hydrochloride, a triazolopyridine antidepressant, are reviewed [5].

References

Trazodone, a triazolopyridine derivative, in primary depressive disorder. Feighner, J.P. The Journal of clinical psychiatry. (1980) [Pubmed]
A controlled study of trazodone, imipramine, and placebo in outpatients with endogenous depression. Mann, J.J., Georgotas, A., Newton, R., Gershon, S. Journal of clinical psychopharmacology. (1981) [Pubmed]
Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development. McClure, K.F., Letavic, M.A., Kalgutkar, A.S., Gabel, C.A., Audoly, L., Barberia, J.T., Braganza, J.F., Carter, D., Carty, T.J., Cortina, S.R., Dombroski, M.A., Donahue, K.M., Elliott, N.C., Gibbons, C.P., Jordan, C.K., Kuperman, A.V., Labasi, J.M., Laliberte, R.E., McCoy, J.M., Naiman, B.M., Nelson, K.L., Nguyen, H.T., Peese, K.M., Sweeney, F.J., Taylor, T.J., Trebino, C.E., Abramov, Y.A., Laird, E.R., Volberg, W.A., Zhou, J., Bach, J., Lombardo, F. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities? Guba, W., Nettekoven, M., Püllmann, B., Riemer, C., Schmitt, S. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
Antidepressant properties of trazodone. Bryant, S.G., Ereshefsky, L. Clinical pharmacy. (1982) [Pubmed]

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