The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Chemical Compound Review: 

AG-E-72466     1- methylsulfonylsulfanylpropane

Synonyms: CTK0J4968, ZINC02387210, AKOS006280203, AC1LB55C, 24387-69-7, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Propyl methanethiosulfonate

  • We demonstrated that the anesthetic propanethiol, or alternatively, propyl methanethiosulfonate, covalently binds to cysteine residues introduced into a specific second transmembrane site in glycine receptor and gamma-aminobutyric acid type A receptor subunits and irreversibly enhances receptor function [1].
  • Furthermore, currents from oocytes injected with high ratios of wt to S267C cDNAs (up to 200:1) were significantly and irreversibly enhanced following propyl methanethiosulfonate labeling and washout, demonstrating that drug binding to a single subunit in the receptor pentamer is sufficient to induce enhancement of GlyR currents [2].

References

  1. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Mascia, M.P., Trudell, J.R., Harris, R.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function. Roberts, M.T., Phelan, R., Erlichman, B.S., Pillai, R.N., Ma, L., Lopreato, G.F., Mihic, S.J. J. Biol. Chem. (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities