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Chemical Compound Review:

DEDA (5Z,8Z)-7,7-dimethylicosa- 5,8-dienoic acid

Synonyms: Lopac-D-8008, AC1NSMI1, BSPBio_001459, D8008_SIGMA, CCG-204554, ...

Giri, S. et al., Wright, H.M. et al., Lister, M.D. et al.

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High impact information on Lopac-D-8008

ET-1 increased 6-keto-PGF1 alpha formation, which was not affected by a PLA2 inhibitor, 7,7-dimethyl eicosadienoic acid (DEDA) [1].
However, 7,7-dimethyl-5,8-eicosadienoic acid was as effective an inhibitor (IC50 = 16 microM) as arachidonic acid [2].
An inhibitor of sPLA2, 7,7-dimethyl eicosadienoic acid, completely attenuated the psychosine-mediated accumulation of LPC levels, release of AA, and generation of reactive oxygen species, and blocked oligodendroyte cell death, as evident from cell survival, DNA fragmentation, and caspase 3 activity assays [3].

References

Prostacyclin formation elicited by endothelin-1 in rat aorta is mediated via phospholipase D activation and not phospholipase C or A2. Wright, H.M., Malik, K.U. Circ. Res. (1996) [Pubmed]
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. Lister, M.D., Glaser, K.B., Ulevitch, R.J., Dennis, E.A. J. Biol. Chem. (1989) [Pubmed]
Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell death. Giri, S., Khan, M., Rattan, R., Singh, I., Singh, A.K. J. Lipid Res. (2006) [Pubmed]

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