Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Isoginkgetin 8-[5-(5,7-dihydroxy-4-oxo- chromen-2-yl)-2...

Synonyms: CHEMBL1208903, BSPBio_002844, KBioGR_002352, KBioSS_000886, CCG-38579, ...

Yoon, S.O. et al.

Yoon, Shin, Lee, Chun, Chung,

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Disease relevance of Isoginkgetin

Isoginkgetin was also quite effective in inhibiting the activities of Akt and MMP-9 in MDA-MB-231 breast carcinomas and B16F10 melanoma [1].
Noncytotoxic levels of isoginkgetin decreased MMP-9 production profoundly, but up-regulated the level of tissue inhibitor of metalloproteinase (TIMP)-1, an inhibitor of MMP-9, in HT1080 human fibrosarcoma cells [1].

References

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Yoon, S.O., Shin, S., Lee, H.J., Chun, H.K., Chung, A.S. Mol. Cancer Ther. (2006) [Pubmed]

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