The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CDC123  -  cell division cycle 123

Homo sapiens

Synonyms: C10orf7, Cell division cycle protein 123 homolog, D123, HT-1080, PZ32, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CDC123


Psychiatry related information on CDC123

  • Near-tetraploid hybrids which contained an approximately complete chromosomal complement from both parental cells were nontumorigenic when 1 X 10(7) cells were injected s.c. into athymic (nude) mice, whereas the parental HT1080 cells produced tumors in 100% of the animals with no latency period following injection of 2 X 10(6) cells [6].

High impact information on CDC123

  • Long-term overexpression of TRF1 in the telomerase-positive tumour-cell line HT1080 resulted in a gradual and progressive telomere shortening [7].
  • The HT-1080 cell line produces both the 72-kd and the 92-kd type IV collagenases [8].
  • In the present study, we demonstrate that alteration of the metalloproteinase-metalloproteinase-inhibitor balance in favor of excess inhibitor blocks human fibrosarcoma HT-1080 tumor cell invasion of a reconstituted basement membrane [8].
  • The specific activities of several antioxidant enzymes, components of the cell's defense against free-radical damage that may be produced by doxorubicin or etoposide, were significantly different in HT1080 and DR4 cytosolic extracts [9].
  • The difference between the HT1080 and DR4 lines in AMSA- and 5-iminodaunorubicin-induced cleavage was similar in cells and nuclei and could be due to the lower amount of DR4 topoisomerase II [9].

Chemical compound and disease context of CDC123


Biological context of CDC123


Anatomical context of CDC123


Associations of CDC123 with chemical compounds


Physical interactions of CDC123


Regulatory relationships of CDC123

  • The two ribozymes that specifically cleaved ROCK1 mRNA inhibited both the migration and invasion of invasive HT1080 fibrosarcoma, but neither had any effect on cell proliferation [28].
  • Migration of HT1080/SDC cells on collagen-coated dishes was significantly slower than that of control HT1080 cells [29].
  • The activity of a p53 response element-driven luciferase reporter was reduced in ATF3-expressing HT1080 clones [30].
  • As a result of cDNA sequence analysis, we found that UCK2 mRNA expressed in EUrd-resistant HT-1080 cells has a 98-base pair deletion of exon 5, whereas EUrd-resistant NUGC-3 cells were harboring the point mutation at nucleotide position 484 (C to T) within exon 4 of UCK2 mRNA [31].
  • Okadaic acid had opposite effects on urokinase (u-PA) gene expression in the two cell lines; u-PA mRNA and gene transcription was suppressed in HT-1080 cells but transiently induced in U-937 cells [32].

Other interactions of CDC123


Analytical, diagnostic and therapeutic context of CDC123


  1. Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells. Paterson, H., Reeves, B., Brown, R., Hall, A., Furth, M., Bos, J., Jones, P., Marshall, C. Cell (1987) [Pubmed]
  2. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Hall, A., Marshall, C.J., Spurr, N.K., Weiss, R.A. Nature (1983) [Pubmed]
  3. Role of plasminogen in matrix breakdown by neoplastic cells. Bogenmann, E., Jones, P.A. J. Natl. Cancer Inst. (1983) [Pubmed]
  4. Tenascin-C signaling through induction of 14-3-3 tau. Martin, D., Brown-Luedi, M., Chiquet-Ehrismann, R. J. Cell Biol. (2003) [Pubmed]
  5. A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1. Volpert, O.V., Lawler, J., Bouck, N.P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency. Benedict, W.F., Weissman, B.E., Mark, C., Stanbridge, E.J. Cancer Res. (1984) [Pubmed]
  7. Control of telomere length by the human telomeric protein TRF1. van Steensel, B., de Lange, T. Nature (1997) [Pubmed]
  8. Tumor cell invasion inhibited by TIMP-2. Albini, A., Melchiori, A., Santi, L., Liotta, L.A., Brown, P.D., Stetler-Stevenson, W.G. J. Natl. Cancer Inst. (1991) [Pubmed]
  9. HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II. Zwelling, L.A., Slovak, M.L., Doroshow, J.H., Hinds, M., Chan, D., Parker, E., Mayes, J., Sie, K.L., Meltzer, P.S., Trent, J.M. J. Natl. Cancer Inst. (1990) [Pubmed]
  10. Suppression of urokinase-type plasminogen activator mRNA levels in human fibrosarcoma cells and synovial fibroblasts by anti-inflammatory glucocorticoids. Medcalf, R.L., Richards, R.I., Crawford, R.J., Hamilton, J.A. EMBO J. (1986) [Pubmed]
  11. Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells. Gupta, S., Stuffrein, S., Plattner, R., Tencati, M., Gray, C., Whang, Y.E., Stanbridge, E.J. Mol. Cell. Biol. (2001) [Pubmed]
  12. Cyclic AMP-regulated synthesis of the tissue inhibitors of metalloproteinases suppresses the invasive potential of the human fibrosarcoma cell line HT1080. Tanaka, K., Iwamoto, Y., Ito, Y., Ishibashi, T., Nakabeppu, Y., Sekiguchi, M., Sugioka, Y. Cancer Res. (1995) [Pubmed]
  13. Effect of ascorbic acid on the resistance of the extracellular matrix to hydrolysis by tumor cells. DeClerck, Y.A., Jones, P.A. Cancer Res. (1980) [Pubmed]
  14. Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Slovak, M.L., Hoeltge, G.A., Dalton, W.S., Trent, J.M. Cancer Res. (1988) [Pubmed]
  15. Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. Skubitz, A.P., Letourneau, P.C., Wayner, E., Furcht, L.T. J. Cell Biol. (1991) [Pubmed]
  16. A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment. Kallunki, P., Sainio, K., Eddy, R., Byers, M., Kallunki, T., Sariola, H., Beck, K., Hirvonen, H., Shows, T.B., Tryggvason, K. J. Cell Biol. (1992) [Pubmed]
  17. CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA. Ohzeki, J., Nakano, M., Okada, T., Masumoto, H. J. Cell Biol. (2002) [Pubmed]
  18. Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I. Bergman, B.L., Scott, R.W., Bajpai, A., Watts, S., Baker, J.B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  19. Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells. Wilhelm, S.M., Collier, I.E., Kronberger, A., Eisen, A.Z., Marmer, B.L., Grant, G.A., Bauer, E.A., Goldberg, G.I. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  20. Isolation and initial characterization of tumoricidal monokine(s) from the human monocytic leukemia cell line THP-1. Armstrong, C.A., Klostergaard, J., Granger, G.A. J. Natl. Cancer Inst. (1985) [Pubmed]
  21. Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. Brown, R., Marshall, C.J., Pennie, S.G., Hall, A. EMBO J. (1984) [Pubmed]
  22. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U.H., Deryugina, E.I., Strongin, A.Y., Bröcker, E.B., Friedl, P. J. Cell Biol. (2003) [Pubmed]
  23. Induction of fibronectin matrix assembly in human fibrosarcoma cells by dexamethasone. McKeown-Longo, P.J., Etzler, C.A. J. Cell Biol. (1987) [Pubmed]
  24. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. Wayner, E.A., Carter, W.G. J. Cell Biol. (1987) [Pubmed]
  25. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. Paulson, T.G., Almasan, A., Brody, L.L., Wahl, G.M. Mol. Cell. Biol. (1998) [Pubmed]
  26. Cellular attachment to thrombospondin. Cooperative interactions between receptor systems. Asch, A.S., Tepler, J., Silbiger, S., Nachman, R.L. J. Biol. Chem. (1991) [Pubmed]
  27. Alpha v beta 5 integrin is localized at focal contacts by HT-1080 fibrosarcoma cells and human skin fibroblasts attached to vitronectin. Conforti, G., Calza, M., Beltrán-Nuñez, A. Cell Adhes. Commun. (1994) [Pubmed]
  28. Identification of genes responsible for cell migration by a library of randomized ribozymes. Suyama, E., Kawasaki, H., Kasaoka, T., Taira, K. Cancer Res. (2003) [Pubmed]
  29. Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. Endo, K., Takino, T., Miyamori, H., Kinsen, H., Yoshizaki, T., Furukawa, M., Sato, H. J. Biol. Chem. (2003) [Pubmed]
  30. ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. Yan, C., Wang, H., Boyd, D.D. J. Biol. Chem. (2002) [Pubmed]
  31. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. Murata, D., Endo, Y., Obata, T., Sakamoto, K., Syouji, Y., Kadohira, M., Matsuda, A., Sasaki, T. Drug Metab. Dispos. (2004) [Pubmed]
  32. Cell- and gene-specific interactions between signal transduction pathways revealed by okadaic acid. Studies on the plasminogen activating system. Medcalf, R.L. J. Biol. Chem. (1992) [Pubmed]
  33. Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. Brown, T.A., Bouchard, T., St John, T., Wayner, E., Carter, W.G. J. Cell Biol. (1991) [Pubmed]
  34. Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. Chitaev, N.A., Troyanovsky, S.M. J. Cell Biol. (1997) [Pubmed]
  35. Role of E2F-1 in chemosensitivity. Banerjee, D., Schnieders, B., Fu, J.Z., Adhikari, D., Zhao, S.C., Bertino, J.R. Cancer Res. (1998) [Pubmed]
  36. Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells. Date, O., Katsura, M., Ishida, M., Yoshihara, T., Kinomura, A., Sueda, T., Miyagawa, K. Cancer Res. (2006) [Pubmed]
  37. Localization of radiolabeled monoclonal antibody in a human soft tissue sarcoma xenograft. Brown, J.M., Greager, J.A., Pavel, D.G., Gupta, T.K. J. Natl. Cancer Inst. (1985) [Pubmed]
  38. Expression of antigenic crossreactivity to RD114 p 30 protein in a human fibrosarcoma cell line. Smith, H.S., Riggs, J.L., Springer, E.L. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  39. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Der, S.D., Zhou, A., Williams, B.R., Silverman, R.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
WikiGenes - Universities