Gene Review:
MMP9 - matrix metallopeptidase 9 (gelatinase B,...
Homo sapiens
Synonyms:
92 kDa gelatinase, 92 kDa type IV collagenase, CLG4B, GELB, Gelatinase B, ...
Burnham,
Challis,
Solini,
Wun,
Adair,
Merli,
Dencoff,
Ritzenthaler,
Kaye,
Soini,
Patel,
Santini,
Chiesa,
Manfrini,
Moss,
Chandrasekar,
Li,
Bailey,
Molendini,
Benassi,
Balladelli,
Unlugedik,
Valente,
Ragazzini,
Belaaouaj,
Autio-Harmainen,
Mahimainathan,
Mummidi,
Roman,
Charlie,
Greene,
Nannipieri,
Stetler-Stevenson,
Bocking,
Mercuri,
Bertoni,
Quinn,
Ferrannini,
Picci,
Camicioli,
Imam,
Satta,
Li,
Magagnoli,
Shapiro,
Welgus,
Gamberi,
Rosenberg,
Määttä,
- The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1. Yoshizaki, T., Sato, H., Furukawa, M., Pagano, J.S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface. Mira, E., Lacalle, R.A., Buesa, J.M., de Buitrago, G.G., Jiménez-Baranda, S., Gómez-Moutón, C., Martínez-A, C., Mañes, S. J. Cell. Sci. (2004)
- Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor. Rowsell, S., Hawtin, P., Minshull, C.A., Jepson, H., Brockbank, S.M., Barratt, D.G., Slater, A.M., McPheat, W.L., Waterson, D., Henney, A.M., Pauptit, R.A. J. Mol. Biol. (2002)
- Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. Soini, Y., Satta, J., Määttä, M., Autio-Harmainen, H. J. Pathol. (2001)
- Associations of matrix metalloproteinase-9 protein polymorphisms with lymph node metastasis but not invasion of gastric cancer. Tang, Y., Zhu, J., Chen, L., Chen, L., Zhang, S., Lin, J. Clin. Cancer Res. (2008)
- Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. Pöllänen, P.J., Lehtimäki, T., Mikkelsson, J., Ilveskoski, E., Kunnas, T., Perola, M., Penttilä, A., Mattila, K.M., Nikkari, S.T., Syrjäkoski, K., Karhunen, P.J. Atherosclerosis (2005)
- Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease. Adair, J.C., Charlie, J., Dencoff, J.E., Kaye, J.A., Quinn, J.F., Camicioli, R.M., Stetler-Stevenson, W.G., Rosenberg, G.A. Stroke (2004)
- HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway. Missé, D., Esteve, P.O., Renneboog, B., Vidal, M., Cerutti, M., St Pierre, Y., Yssel, H., Parmentier, M., Veas, F. Blood (2001)
- Matrix metalloproteinases in dog brains exhibiting Alzheimer-like characteristics. Lim, G.P., Russell, M.J., Cullen, M.J., Tökés, Z.A. J. Neurochem. (1997)
- Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Burnham, E.L., Moss, M., Ritzenthaler, J.D., Roman, J. Alcohol. Clin. Exp. Res. (2007)
- Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Kim, J., Yu, W., Kovalski, K., Ossowski, L. Cell (1998)
- The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., Glass, C.K. Nature (1998)
- Matrilysin-dependent elastolysis by human macrophages. Filippov, S., Caras, I., Murray, R., Matrisian, L.M., Chapman, H.A., Shapiro, S., Weiss, S.J. J. Exp. Med. (2003)
- Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis. Herman, M.P., Sukhova, G.K., Kisiel, W., Foster, D., Kehry, M.R., Libby, P., Schönbeck, U. J. Clin. Invest. (2001)
- Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells. Alper O, n.u.l.l., Bergmann-Leitner, E.S., Bennett, T.A., Hacker, N.F., Stromberg, K., Stetler-Stevenson, W.G. J. Natl. Cancer Inst. (2001)
- Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. Cha, H.J., Bae, S.K., Lee, H.Y., Lee, O.H., Sato, H., Seiki, M., Park, B.C., Kim, K.W. Cancer Res. (1996)
- Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells. Zhao, Y.G., Xiao, A.Z., Newcomer, R.G., Park, H.I., Kang, T., Chung, L.W., Swanson, M.G., Zhau, H.E., Kurhanewicz, J., Sang, Q.X. J. Biol. Chem. (2003)
- Thrombosed arteriovenous fistula for hemodialysis access is characterized by a marked inflammatory activity. Chang, C.J., Ko, Y.S., Ko, P.J., Hsu, L.A., Chen, C.F., Yang, C.W., Hsu, T.S., Pang, J.H. Kidney Int. (2005)
- (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. Kim, M., Murakami, A., Kawabata, K., Ohigashi, H. Carcinogenesis (2005)
- The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Joos, L., He, J.Q., Shepherdson, M.B., Connett, J.E., Anthonisen, N.R., Paré, P.D., Sandford, A.J. Hum. Mol. Genet. (2002)
- Fourteenth Annual Pezcoller Symposium: the novel dichotomy of immune interactions with tumors. Hanahan, D., Lanzavecchia, A., Mihich, E. Cancer Res. (2003)
- Differential Expression of Matrix Metalloproteinase 3 (MMP3) in Preadipocytes/Stromal Vascular Cells From Nonobese Nondiabetic Versus Obese Nondiabetic Pima Indians. Traurig, M.T., Permana, P.A., Nair, S., Kobes, S., Bogardus, C., Baier, L.J. Diabetes (2006)
- Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. Chandrasekar, B., Mummidi, S., Mahimainathan, L., Patel, D.N., Bailey, S.R., Imam, S.Z., Greene, W.C., Valente, A.J. J. Biol. Chem. (2006)
- High glucose and homocysteine synergistically affect the metalloproteinases-tissue inhibitors of metalloproteinases pattern, but not TGFB expression, in human fibroblasts. Solini, A., Santini, E., Nannipieri, M., Ferrannini, E. Diabetologia (2006)
- Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. Nie, J., Pei, D. Exp. Cell Res. (2004)
- Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. Bauer, S., Pollheimer, J., Hartmann, J., Husslein, P., Aplin, J.D., Knöfler, M. J. Clin. Endocrinol. Metab. (2004)
- The Role of Prostaglandins in the Mechanism of Lipopolysaccharide-Induced proMMP9 Secretion from Human Placenta and Fetal Membrane Cells. Li, W., Unlugedik, E., Bocking, A.D., Challis, J.R. Biol. Reprod. (2007)
- Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis. Hitchon, C.A., Danning, C.L., Illei, G.G., El-Gabalawy, H.S., Boumpas, D.T. J. Rheumatol. (2002)
- Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Symowicz, J., Adley, B.P., Gleason, K.J., Johnson, J.J., Ghosh, S., Fishman, D.A., Hudson, L.G., Stack, M.S. Cancer Res. (2007)
- Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. Radjabi, A.R., Sawada, K., Jagadeeswaran, S., Eichbichler, A., Kenny, H.A., Montag, A., Bruno, K., Lengyel, E. J. Biol. Chem. (2008)
- Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B. Sancéau, J., Boyd, D.D., Seiki, M., Bauvois, B. J. Biol. Chem. (2002)
- A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis. Annabi, B., Bouzeghrane, M., Currie, J.C., Hawkins, R., Dulude, H., Daigneault, L., Ruiz, M., Wisniewski, J., Garde, S., Rabbani, S.A., Panchal, C., Wu, J.J., Béliveau, R. Clin. Exp. Metastasis (2005)
- Generation and activity of the ternary gelatinase B/TIMP-1/LMW-stromelysin-1 complex. Kolkenbrock, H., Orgel, D., Hecker-Kia, A., Zimmermann, J., Ulbrich, N. Biol. Chem. Hoppe-Seyler (1995)
- KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation. Yan, C., Wang, H., Boyd, D.D. J. Biol. Chem. (2001)
- Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase. Collier, I.E., Krasnov, P.A., Strongin, A.Y., Birkedal-Hansen, H., Goldberg, G.I. J. Biol. Chem. (1992)
- Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. Aimes, R.T., Quigley, J.P. J. Biol. Chem. (1995)
- Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation. Belaaouaj, A.A., Li, A., Wun, T.C., Welgus, H.G., Shapiro, S.D. J. Biol. Chem. (2000)
- Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy. Nelissen, I., Martens, E., Van den Steen, P.E., Proost, P., Ronsse, I., Opdenakker, G. Brain (2003)
- Insulin-like growth factor binding protein 3 in inflammatory bowel disease. Kirman, I., Whelan, R.L., Jain, S., Nielsen, S.E., Seidelin, J.B., Nielsen, O.H. Dig. Dis. Sci. (2005)
- Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Dechow, T.N., Pedranzini, L., Leitch, A., Leslie, K., Gerald, W.L., Linkov, I., Bromberg, J.F. Proc. Natl. Acad. Sci. U.S.A. (2004)
- MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Chen, Y., Fan, Y., Poon, K.Y., Achrol, A.S., Lawton, M.T., Zhu, Y., McCulloch, C.E., Hashimoto, T., Lee, C., Barbaro, N.M., Bollen, A.W., Yang, G.Y., Young, W.L. Front. Biosci. (2006)
- Unopposed matrix metalloproteinase-9 expression in human tuberculous granuloma and the role of TNF-alpha-dependent monocyte networks. Price, N.M., Gilman, R.H., Uddin, J., Recavarren, S., Friedland, J.S. J. Immunol. (2003)
- Fibronectin-mediated cell adhesion is required for induction of 92-kDa type IV collagenase/gelatinase (MMP-9) gene expression during macrophage differentiation. The signaling role of protein kinase C-beta. Xie, B., Laouar, A., Huberman, E. J. Biol. Chem. (1998)
- Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon alpha(4)beta(1)-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Yakubenko, V.P., Lobb, R.R., Plow, E.F., Ugarova, T.P. Exp. Cell Res. (2000)
- Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade. Dreier, R., Grässel, S., Fuchs, S., Schaumburger, J., Bruckner, P. Exp. Cell Res. (2004)
- Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB. Bhoopathi, P., Chetty, C., Kunigal, S., Vanamala, S.K., Rao, J.S., Lakka, S.S. J. Biol. Chem. (2008)
- Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. Marbaix, E., Donnez, J., Courtoy, P.J., Eeckhout, Y. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through RAS/MAP kinase signaling pathways. Esparza, J., Vilardell, C., Calvo, J., Juan, M., Vives, J., Urbano-Márquez, A., Yagüe, J., Cid, M.C. Blood (1999)
- Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. Van den Steen, P.E., Proost, P., Wuyts, A., Van Damme, J., Opdenakker, G. Blood (2000)
- Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors. Morán, A., Iniesta, P., de Juan, C., González-Quevedo, R., Sánchez-Pernaute, A., Díaz-Rubio, E., Ramón y Cajal, S., Torres, A., Balibrea, J.L., Benito, M. Cancer Res. (2002)
- Matrix metalloproteinases expression correlates with survival in patients with esophageal squamous cell carcinoma. Gu, Z.D., Li, J.Y., Li, M., Gu, J., Shi, X.T., Ke, Y., Chen, K.N. Am. J. Gastroenterol. (2005)
- Metalloproteinase expression and prognosis in soft tissue sarcomas. Benassi, M.S., Gamberi, G., Magagnoli, G., Molendini, L., Ragazzini, P., Merli, M., Chiesa, F., Balladelli, A., Manfrini, M., Bertoni, F., Mercuri, M., Picci, P. Ann. Oncol. (2001)
- Simultaneous measurement of MMP9 and TIMP1 mRNA in human non small cell lung cancers by multiplex real time RT-PCR. Simi, L., Andreani, M., Davini, F., Janni, A., Pazzagli, M., Serio, M., Orlando, C. Lung Cancer (2004)
- Characteristics of the Inflammatory response in bronchial lavage fluids from patients with status asthmaticus. Tonnel, A.B., Gosset, P., Tillie-Leblond, I. Int. Arch. Allergy Immunol. (2001)