Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NT032 [(1R,4aS)-4-[2-(3- furyl)ethyl]-4-hydroxy-3...

Synonyms:

Ko, W.G. et al., Hajdú, Z. et al.

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High impact information on Rotundifuran

From the n-hexane fraction of the fruits of Vitex agnus-castus, two labdane-type diterpenes, vitetrifolin B and C, were isolated by means of multiple chromatographic separations, together with the previously identified rotundifuran, vitexilactone and the sesquiterpene spathulenol [1].
Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells [2].
The inhibitory effect of rotundifuran, a labdane type diterpene isolated from the fruit of Vitex rotundifolia, on the proliferation of human myeloid leukaemia HL-60 cells was examined [2].
The mode of cell death induced by rotundifuran was found to be apoptosis, which was judged by the morphological alteration of the cells and by the detection of DNA fragmentation using agarose gel electrophoresis [2].

References

Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. Hajdú, Z., Hohmann, J., Forgo, P., Martinek, T., Dervarics, M., Zupkó, I., Falkay, G., Cossuta, D., Máthé, I. Phytotherapy research : PTR (2007) [Pubmed]
Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells. Ko, W.G., Kang, T.H., Lee, S.J., Kim, Y.C., Lee, B.H. Phytotherapy research : PTR. (2001) [Pubmed]

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