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Chemical Compound Review:

AC1NT05F (2S,3R,4S,5S,6R)-2- [(2S,3R,4S,5R,6R)-3,5...

Synonyms: Ambotz58316-41-9

Cheng, P.W. et al., Ushio, Y. et al., Zong, Z. et al., Zong, Z. et al.

Zong, Fujikawa-Yamamoto, Ota, Guan, Murakami, Li, Yamaguchi, Tanino, Odashima,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Saikosaponin B2

Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity [1].
In the time-of-addition studies, saikosaponin B2, at 6 micromol/L, significantly inhibited human coronavirus 229E infection following its addition at various time pre-infection (-4 to -1 h), coinfection (0 h) and post-infection (1-4 h) [2].

High impact information on Saikosaponin B2

An increase in phagocytosis was detected after treatment with saikosaponin-b2 (0.1 microM) for 24 h in vitro, while a suppression of phagocytosis was observed following treatment with saikosaponins (0.5 microM) [3].
Using the 2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-5-[(phenylamino) carbonyl-2H-tetrazolium hydroxide] (XTT) assay, results showed that all saikosaponins tested demonstrated antiviral activity at concentrations of 0.25-25 micromol/L, with the strongest activity being noted for saikosaponin B2 (IC50 = 1.7 +/- 0.1 micromol/L) [2].
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells [4].

References

Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity. Zong, Z., Fujikawa-Yamamoto, K., Tanino, M., Teraoka, K., Yamagishi, H., Odashima, S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
Antiviral effects of saikosaponins on human coronavirus 229E in vitro. Cheng, P.W., Ng, L.T., Chiang, L.C., Lin, C.C. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
The effects of saikosaponin on macrophage functions and lymphocyte proliferation. Ushio, Y., Abe, H. Planta Med. (1991) [Pubmed]
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells. Zong, Z., Fujikawa-Yamamoto, K., Ota, T., Guan, X., Murakami, M., Li, A., Yamaguchi, N., Tanino, M., Odashima, S. Cell Struct. Funct. (1998) [Pubmed]

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