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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1NT05F     (2S,3R,4S,5S,6R)-2- [(2S,3R,4S,5R,6R)-3,5...

Synonyms: Ambotz58316-41-9
 
 
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Disease relevance of Saikosaponin B2

 

High impact information on Saikosaponin B2

  • An increase in phagocytosis was detected after treatment with saikosaponin-b2 (0.1 microM) for 24 h in vitro, while a suppression of phagocytosis was observed following treatment with saikosaponins (0.5 microM) [3].
  • Using the 2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-5-[(phenylamino) carbonyl-2H-tetrazolium hydroxide] (XTT) assay, results showed that all saikosaponins tested demonstrated antiviral activity at concentrations of 0.25-25 micromol/L, with the strongest activity being noted for saikosaponin B2 (IC50 = 1.7 +/- 0.1 micromol/L) [2].
  • Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells [4].

References

  1. Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity. Zong, Z., Fujikawa-Yamamoto, K., Tanino, M., Teraoka, K., Yamagishi, H., Odashima, S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  2. Antiviral effects of saikosaponins on human coronavirus 229E in vitro. Cheng, P.W., Ng, L.T., Chiang, L.C., Lin, C.C. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  3. The effects of saikosaponin on macrophage functions and lymphocyte proliferation. Ushio, Y., Abe, H. Planta Med. (1991) [Pubmed]
  4. Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells. Zong, Z., Fujikawa-Yamamoto, K., Ota, T., Guan, X., Murakami, M., Li, A., Yamaguchi, N., Tanino, M., Odashima, S. Cell Struct. Funct. (1998) [Pubmed]
 
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