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Chemical Compound Review:

Thunberginol A 3-(3,4-dihydroxyphenyl)-8- hydroxy...

Synonyms: CHEMBL68810, SureCN12680535, NSC-724383, NSC724383, HMS2271A09, ...

Shimoda, H. et al., Matsuda, H. et al., Matsuda, H. et al.

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High impact information on Thunberginol A

Thunberginol A also suppressed B lymphocyte proliferation induced by lipopolysaccharide, but other constituents induced significant increases [1].
The role of the signal transmission pathway of thunberginol A (TA) in mast cell degranulation was examined using rat peritoneal mast cells [2].
On the other hand, thunberginol A significantly suppressed T lymphocyte proliferation stimulated by concanavalin A (Con A), but did not suppress phytohemagglutinin (PHA) [3].
Development of bioactive functions in Hydrangeae Dulcis Folium. VII. Immunomodulatory activities of thunberginol A and related compounds on lymphocyte proliferation [3].

Anatomical context of Thunberginol A

These results suggest that thunberginol A acts on both B and T lymphocytes and may have a suppressive mechanism different from the known immunosuppressants [3].

References

Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens. Matsuda, H., Shimoda, H., Yamahara, J., Yoshikawa, M. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
The role of thunberginol A, an isocoumarin constituent of Hydrangeae Dulcis Folium, on the signal transmission pathway for rat mast cell degranulation. Matsuda, H., Shimoda, H., Kageura, T., Yoshikawa, M. Biol. Pharm. Bull. (1999) [Pubmed]
Development of bioactive functions in Hydrangeae Dulcis Folium. VII. Immunomodulatory activities of thunberginol A and related compounds on lymphocyte proliferation. Shimoda, H., Matsuda, H., Yamahara, J., Yoshikawa, M. Biol. Pharm. Bull. (1998) [Pubmed]

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