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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Zincon     2-[2-[N-[(6-oxo-3-sulfo-1- cyclohexa-2,4...

Synonyms: STOCK2S-09317, STK720135, AKOS005523973, AC1NS5B3, 135-52-4, ...
 
 
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High impact information on Zincon

  • The results are interpreted in terms of complexation of zincon to a zinc atom at the enzyme active site [1].
  • The reactivity of Zn-TFIIIA with a series of metal binding ligands, including 2-carboxy-2'-hydroxy-5'-sulfoformazylbenzene (zincon), 4-(2-pyridylazo)-resorcinol (PAR), and 3-ethoxy-2-oxo-butyraldehyde-bis-(N(4)-dimethylthiosemicarbazone) (H(2)KTSM(2)) revealed similar kinetics [2].
  • The free Zincon, and the complexes Zn-Zincon and Cu-Zincon, does not partition into organic solvents, does not permeate liposome membrane, and neither does it interact with biological membranes [3].

References

  1. Resonance Raman investigation of an enzyme-inhibitor complex. McFarland, J.T., Watters, K.L., Petersen, R.L. Biochemistry (1975) [Pubmed]
  2. Zn-, Cd-, and Pb-transcription factor IIIA: properties, DNA binding, and comparison with TFIIIA-finger 3 metal complexes. Huang, M., Krepkiy, D., Hu, W., Petering, D.H. J. Inorg. Biochem. (2004) [Pubmed]
  3. Determination of the physicochemical constants and spectrophotometric characteristics of the metallochromic Zincon and its potential use in biological systems. Hilario, E., Romero, I., Celis, H. J. Biochem. Biophys. Methods (1990) [Pubmed]
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