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Chemical Compound Review

Liposome     2-amino-3-(2,3- dihydroxypropoxy-hydroxy...

Synonyms: DMPC & PS & CH, AC1L9R31
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Disease relevance of CHO


Psychiatry related information on CHO

  • These data indicate that elucidation of the effects of liposome composition on acquired host defense mechanisms may be useful for the design of drug delivery systems that allow expression or augmentation of immunologically induced mechanisms for the intracellular destruction of infectious agents [6].
  • The amount of coupled BSA was affected by the reaction time, the composition of the liposome and the BSA concentration in the reactant [7].
  • The ability of liposomes to meet essential requirements for task performance and liposome surface-modification as the major approach to endow liposomes with targeting abilities are reviewed [8].
  • Liposome encapsulated prostaglandin E1 in erectile dysfunction: correlation between in vitro delivery through foreskin and efficacy in patients [9].
  • The competitive behavior of solid vs. fluid liposomes in liposome-to-cell adsorption and cell-to-liposome lipid transfer processes was investigated with L cells and FBT epithelial sheets [10].

High impact information on CHO


Chemical compound and disease context of CHO


Biological context of CHO


Anatomical context of CHO

  • Evidence for translation of rabbit globin mRNA after liposome-mediated insertion into a human cell line [26].
  • Liposome fusion releases only trace quantities of the trapped solute into the cytoplasm and incorporates foreign lipid into the target cell membranes [27].
  • Enzyme replacement using liposome carriers in feline Gm1 gangliosidosis fibroblasts [28].
  • Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes [29].
  • Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome treatment of cells [30].

Associations of CHO with other chemical compounds

  • The values for liposome-encapsulated doxorubicin in parental HL-60 cells and HL-60/ADR cells were 20 nM and 9 microM, respectively, indicating little or no sensitization [31].
  • Liposome-encapsulated Ara-C (5 mg/kg) effectively suppressed macromolecular incorporation of [14C]dThd in the lung but had little effect on this process in the gut and bone marrow [32].
  • Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein [33].
  • Anionic liposome compositions (e.g., phosphatidylserine) that mimic the cytoplasmic facing monolayer of the cell membrane released ODN from the complex at about a 1:1 (-/+) charge ratio [34].
  • As in the case of liposome-mediated incorporation, the amyloid channel activity in the patch pipet exhibits multiple conductance levels between 40 and 400 pS, cation selectivity, and sensitivity to tromethamine (Tris) [35].

Gene context of CHO


Analytical, diagnostic and therapeutic context of CHO

  • UK scientists test liposome gene therapy technique [41].
  • A single intravenous injection of expression plasmid:cationic liposome complexes into adult mice efficiently transfected virtually all tissues [42].
  • The IgM secreted by a hybridoma derived from one of the lymphomas, CH12, was shown to agglutinate liposomes, and was used in a solid-phase immunoassay to study inhibition of liposome binding by pure phospholipids; DSPC and sphingomyelin both inhibited, whereas DSPG did not [43].
  • The PIB liposome antisera also had higher ELISA titers to a synthetic peptide equivalent to an exposed portion of PIB and a higher percentage of antibodies absorbed by whole organisms than the PIB alum antisera [44].
  • METHODS: Intratumoral cationic liposome-mediated gene transfer was used to deliver plasmids capable of expressing sense or antisense EGFR sequences into human head and neck tumors, which were grown as subcutaneous xenografts in nude mice [45].


  1. Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Alton, E.W., Middleton, P.G., Caplen, N.J., Smith, S.N., Steel, D.M., Munkonge, F.M., Jeffery, P.K., Geddes, D.M., Hart, S.L., Williamson, R. Nat. Genet. (1993) [Pubmed]
  2. Doxorubicin in sterically stabilized liposomes. Lasic, D.D. Nature (1996) [Pubmed]
  3. Liposome-induced morphological differentiation of murine neuroblastoma. Chen, J.S., Del Fa, A., Di Luzio, A., Calissano, P. Nature (1976) [Pubmed]
  4. Porins in the cell wall of mycobacteria. Trias, J., Jarlier, V., Benz, R. Science (1992) [Pubmed]
  5. Liposome accumulation in regions of experimental myocardial infarction. Caride, V.J., Zaret, B.L. Science (1977) [Pubmed]
  6. Differential inhibition of macrophage microbicidal activity by liposomes. Gilbreath, M.J., Swartz, G.M., Alving, C.R., Nacy, C.A., Hoover, D.L., Meltzer, M.S. Infect. Immun. (1985) [Pubmed]
  7. Liposome immunoassay (LIA) with antigen-coupled liposomes containing alkaline phosphatase. Kim, C.K., Lim, S.J. J. Immunol. Methods (1993) [Pubmed]
  8. Liposome-mediated drug targeting in topical and regional therapies. Margalit, R. Critical reviews in therapeutic drug carrier systems. (1995) [Pubmed]
  9. Liposome encapsulated prostaglandin E1 in erectile dysfunction: correlation between in vitro delivery through foreskin and efficacy in patients. Foldvari, M., Oguejiofor, C., Afridi, S., Kudel, T., Wilson, T. Urology (1998) [Pubmed]
  10. Lipid-cell interactions. Liposome adsorption and cell-to-liposome lipid transfer are mediated by the same cell-surface sites. Margolis, L.B., Baibakov, B.A., Neyfakh, A.A., Victorov, A.V., Galkina, S.I., Bergelson, L.D. Biochim. Biophys. Acta (1984) [Pubmed]
  11. Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Bremser, M., Nickel, W., Schweikert, M., Ravazzola, M., Amherdt, M., Hughes, C.A., Söllner, T.H., Rothman, J.E., Wieland, F.T. Cell (1999) [Pubmed]
  12. Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Harding, C.V., Collins, D.S., Slot, J.W., Geuze, H.J., Unanue, E.R. Cell (1991) [Pubmed]
  13. Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesicles. Straubinger, R.M., Hong, K., Friend, D.S., Papahadjopoulos, D. Cell (1983) [Pubmed]
  14. Active transport of Ca2+ by an artificial photosynthetic membrane. Bennett, I.M., Farfano, H.M., Bogani, F., Primak, A., Liddell, P.A., Otero, L., Sereno, L., Silber, J.J., Moore, A.L., Moore, T.A., Gust, D. Nature (2002) [Pubmed]
  15. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Caplen, N.J., Alton, E.W., Middleton, P.G., Dorin, J.R., Stevenson, B.J., Gao, X., Durham, S.R., Jeffery, P.K., Hodson, M.E., Coutelle, C. Nat. Med. (1995) [Pubmed]
  16. Liposome-encapsulated methotrexate interactions with human chronic lymphocytic leukemia cells. Todd, J.A., Levine, A.M., Tökés, Z.A. J. Natl. Cancer Inst. (1980) [Pubmed]
  17. Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide. MacEwen, E.G., Kurzman, I.D., Rosenthal, R.C., Smith, B.W., Manley, P.A., Roush, J.K., Howard, P.E. J. Natl. Cancer Inst. (1989) [Pubmed]
  18. Intralymphatic administration of liposome-encapsulated drugs to mice: possibility for suppression of the growth of tumor metastases in the lymph nodes. Kaledin, V.I., Matienko, N.A., Nikolin, V.P., Gruntenko, Y.V., Budker, V.G. J. Natl. Cancer Inst. (1981) [Pubmed]
  19. Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil. Sela, S., Husain, S.R., Pearson, J.W., Longo, D.L., Rahman, A. J. Natl. Cancer Inst. (1995) [Pubmed]
  20. Exposure of human ovarian carcinoma to cisplatin transiently sensitizes the tumor cells for liposome-mediated gene transfer. Son, K., Huang, L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  21. Cationic liposome-mediated transfection. Felgner, P.L., Ringold, G.M. Nature (1989) [Pubmed]
  22. Liposomes as gene carriers: efficient transformation of mouse L cells by thymidine kinase gene. Schaefer-Ridder, M., Wang, Y., Hofschneider, P.H. Science (1982) [Pubmed]
  23. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. Nair, S., Zhou, F., Reddy, R., Huang, L., Rouse, B.T. J. Exp. Med. (1992) [Pubmed]
  24. Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. Turrens, J.F., Crapo, J.D., Freeman, B.A. J. Clin. Invest. (1984) [Pubmed]
  25. Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury. Takeshita, S., Gal, D., Leclerc, G., Pickering, J.G., Riessen, R., Weir, L., Isner, J.M. J. Clin. Invest. (1994) [Pubmed]
  26. Evidence for translation of rabbit globin mRNA after liposome-mediated insertion into a human cell line. Ostro, M.J., Giacomoni, D., Lavelle, D., Paxton, W., Dray, S. Nature (1978) [Pubmed]
  27. A non-disruptive technique for loading calcium buffers and indicators into cells. Tsien, R.Y. Nature (1981) [Pubmed]
  28. Enzyme replacement using liposome carriers in feline Gm1 gangliosidosis fibroblasts. Reynolds, G.C., Baker, H.J., Reynolds, R.H. Nature (1978) [Pubmed]
  29. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes. Rädler, J.O., Koltover, I., Salditt, T., Safinya, C.R. Science (1997) [Pubmed]
  30. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Viala, J., Chaput, C., Boneca, I.G., Cardona, A., Girardin, S.E., Moran, A.P., Athman, R., Mémet, S., Huerre, M.R., Coyle, A.J., DiStefano, P.S., Sansonetti, P.J., Labigne, A., Bertin, J., Philpott, D.J., Ferrero, R.L. Nat. Immunol. (2004) [Pubmed]
  31. Liposome-mediated modulation of multidrug resistance in human HL-60 leukemia cells. Rahman, A., Husain, S.R., Siddiqui, J., Verma, M., Agresti, M., Center, M., Safa, A.R., Glazer, R.I. J. Natl. Cancer Inst. (1992) [Pubmed]
  32. Organ-selective action of an antitumor drug: pharmacologic studies of liposome-encapsulated beta-cytosine arabinoside administered via the respiratory system of the rat. McCullough, H.N., Juliano, R.L. J. Natl. Cancer Inst. (1979) [Pubmed]
  33. Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein. Hernandez, L.D., Peters, R.J., Delos, S.E., Young, J.A., Agard, D.A., White, J.M. J. Cell Biol. (1997) [Pubmed]
  34. Mechanism of oligonucleotide release from cationic liposomes. Zelphati, O., Szoka, F.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  35. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Arispe, N., Pollard, H.B., Rojas, E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  36. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Kliche, S., Nagel, W., Kremmer, E., Atzler, C., Ege, A., Knorr, T., Koszinowski, U., Kolanus, W., Haas, J. Mol. Cell (2001) [Pubmed]
  37. Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer. Lin, B.R., Chang, C.C., Che, T.F., Chen, S.T., Chen, R.J., Yang, C.Y., Jeng, Y.M., Liang, J.T., Lee, P.H., Chang, K.J., Chau, Y.P., Kuo, M.L. Gastroenterology (2005) [Pubmed]
  38. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Grandis, J.R., Drenning, S.D., Zeng, Q., Watkins, S.C., Melhem, M.F., Endo, S., Johnson, D.E., Huang, L., He, Y., Kim, J.D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  39. Determinants of liposome fusion mediated by synaptic SNARE proteins. Schuette, C.G., Hatsuzawa, K., Margittai, M., Stein, A., Riedel, D., Küster, P., König, M., Seidel, C., Jahn, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  40. Adoptive transfer of anti-CD3-activated CD4+ T cells plus cyclophosphamide and liposome-encapsulated interleukin-2 cure murine MC-38 and 3LL tumors and establish tumor-specific immunity. Saxton, M.L., Longo, D.L., Wetzel, H.E., Tribble, H., Alvord, W.G., Kwak, L.W., Leonard, A.S., Ullmann, C.D., Curti, B.D., Ochoa, A.C. Blood (1997) [Pubmed]
  41. UK scientists test liposome gene therapy technique. Dickson, D. Nature (1993) [Pubmed]
  42. Systemic gene expression after intravenous DNA delivery into adult mice. Zhu, N., Liggitt, D., Liu, Y., Debs, R. Science (1993) [Pubmed]
  43. Phosphatidyl choline is recognized by a series of Ly-1+ murine B cell lymphomas specific for erythrocyte membranes. Mercolino, T.J., Arnold, L.W., Haughton, G. J. Exp. Med. (1986) [Pubmed]
  44. Characterization and specificity of antibodies to protein I of Neisseria gonorrhoeae produced by injection with various protein I-adjuvant preparations. Wetzler, L.M., Blake, M.S., Gotschlich, E.C. J. Exp. Med. (1988) [Pubmed]
  45. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. He, Y., Zeng, Q., Drenning, S.D., Melhem, M.F., Tweardy, D.J., Huang, L., Grandis, J.R. J. Natl. Cancer Inst. (1998) [Pubmed]
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