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Chemical Compound Review:

CHEMBL276618 7,8-dihydroxy-4-methyl- chromen-2-one

Synonyms: BSPBio_002072, KBioGR_002102, KBioSS_001513, ACMC-20alxk, CCG-38597, ...

Hoult, J.R. et al., Kohli, E. et al., Raj, H.G. et al., Raj, H.G. et al.

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High impact information on NSC45795

7,8-Dihydroxy-4-methylcoumarin (1, DHMC) and 7,8-diacetoxy-4-methylcoumarin (2, DAMC) were shown to possess radical scavenging property and strongly inhibit membrane lipid peroxidation [1].
The action of TAase and DAMC on liver cytosolic GST resulted in the formation of monoacetoxymonohydroxy-4-methylcoumarin (MAMHC) and 7,8-dihydroxy-4-methylcoumarin (DHMC), although the former was the major metabolite [2].
6. Simple coumarins possessing ortho-dihydroxy functions, such as fraxetin and 4-methyldaphnetin, are potent inhibitors (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions [3].

Biological context of NSC45795

7,8-Dihydroxy-4-methylcoumarin (DHMC) and 7,8-diacetoxy-4-methylcoumarin (DAMC) have been reported to effectively inhibit in-vivo lipid peroxidation in rat tissues induced by CCl4 and paraquat [4].

References

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Raj, H.G., Parmar, V.S., Jain, S.C., Priyadarsini, K.I., Mittal, J.P., Goel, S., Das, S.K., Sharma, S.K., Olsen, C.E., Wengel, J. Bioorg. Med. Chem. (1999) [Pubmed]
Acetoxy drug: protein transacetylase of buffalo liver-characterization and mass spectrometry of the acetylated protein product. Kohli, E., Gaspari, M., Raj, H.G., Parmar, V.S., Sharma, S.K., van der Greef, J., Kumari, R., Gupta, G., Seema, n.u.l.l., Khurana, P., Tyagi, Y.K., Watterson, A.C., Olsen, C.E. Biochim. Biophys. Acta (2004) [Pubmed]
Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Hoult, J.R., Payá, M. Gen. Pharmacol. (1996) [Pubmed]
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-methylcoumarins mediated by the formation of a stable ADP-Fe-inhibitor mixed ligand complex. Raj, H.G., Sharma, R.K., Garg, B.S., Parmar, V.S., Jain, S.C., Goel, S., Tyagi, Y.K., Singh, A., Olsen, C.E., Wengel, J. Bioorg. Med. Chem. (1998) [Pubmed]

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