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Gene Review

LITAF  -  lipopolysaccharide-induced TNF factor

Homo sapiens

Synonyms: FLJ38636, LPS-induced TNF-alpha factor, Lipopolysaccharide-induced tumor necrosis factor-alpha factor, PIG7, SIMPLE, ...
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Disease relevance of LITAF


Psychiatry related information on LITAF


High impact information on LITAF


Chemical compound and disease context of LITAF

  • Clomid for unexplained infertility? Simple lie or complicated truth [14]?
  • Based on multiple linear regression, the Simple Endoscopic Score for Crohn's Disease resulted in the sum of the scores for ulcer size, ulcerated surface, affected surface, and luminal narrowing [15].
  • All had the following tests: gastric biopsies (2 antral, 1 fundus; H&E and Alcian Yellow stain) examined for gastritis and H pylori; (13)C-UBT; capillary blood for whole blood rapid antibody tests: FlexSure HP, QuickVue, AccuStat, and Stat-Simple Pylori; serum for FlexSure HP; HM-CAP enzyme-linked immunoassay [16].
  • The NCTB consists of 7 neurobehavioral tests (Digit Symbol, Digit Span, Benton visual memory test/recognition form, Santa Ana dexterity test, Simple Reaction Time, Pursuit Aiming II, and Profile of Mood States) [17].
  • In the 20-29 and the 30-39 age ranges, there was a prevalence of POMS scale scores below 10th percentile rank, in the 50-59 age range, the percentages were high for the Digit Symbol, the mean value of Simple Reaction Time, Serial Digit Learning, and Benton Visual Recognition [18].

Biological context of LITAF


Anatomical context of LITAF

  • In addition, high level of expression of LITAF mRNA was observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes, and the spleen [20].
  • CONCLUSIONS: Mutations in LITAF may account for a significant proportion of CMT1 patients with previously unknown molecular diagnosis and may define a new mechanism of peripheral nerve perturbation leading to demyelinating neuropathy [22].
  • The LITAF transcript is expressed in sciatic nerve, but its level of expression is not altered during development or in response to nerve injury [22].
  • Western blot analysis suggested that the T115N and W116G mutations do not alter the level of LITAF protein in peripheral blood lymphocytes [22].
  • Similarly, in inflamed ileal tissues from patients with CD, LITAF is also localized to lamina propria macrophages [3].

Associations of LITAF with chemical compounds

  • 2) The coding region of the transcript differs from LITAF/PIG7 due to an absence of a single guanine residue, resulting in a potential translational frameshift [23].
  • A Simple Method for Kinetic Control of DNA-Induced Nanoparticle Assembly [24].
  • 24-hour mean pulse. Simple predictor of doxorubicin-induced cardiac damage [25].
  • The Mannich Reaction of Malonates with Simple Imines Catalyzed by Bifunctional Cinchona Alkaloids: Enantioselective Synthesis of beta-Amino Acids [26].
  • RESULTS: Simple correlation analysis revealed a significant direct correlation in blacks (but not whites) between gonadal androgens and AUC for glucose, insulin, and C-peptide [27].

Physical interactions of LITAF

  • In this study, we identify by footprinting a sequence motif, CTCCC (-515 to -511), within the TNF-alpha promoter that binds to hLITAF [28].

Regulatory relationships of LITAF

  • List Simple software permitted analysis of each specimen together with its isotype control (IgG1) on the same cytogram so that p53 expression could be determined separately for the diploid and aneuploid populations of aneuploid tumors and for tumor cells of diploid tumors in the various phases of the cell cycle [29].
  • CONCLUSIONS: Simple surgical excision of the cyst "membrane" of epileptogenic poroencephalic cysts can represent an excellent means to control epilepsy in affected children [30].

Other interactions of LITAF


Analytical, diagnostic and therapeutic context of LITAF


  1. PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's disease. Matsumura, Y., Matsumura, Y., Nishigori, C., Horio, T., Miyachi, Y. Int. J. Cancer (2004) [Pubmed]
  2. SIMPLE mutation analysis in dominant demyelinating Charcot-Marie-Tooth disease: three novel mutations. Latour, P., Gonnaud, P.M., Ollagnon, E., Chan, V., Perelman, S., Stojkovic, T., Stoll, C., Vial, C., Ziegler, F., Vandenberghe, A., Maire, I. J. Peripher. Nerv. Syst. (2006) [Pubmed]
  3. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Stucchi, A., Reed, K., O'Brien, M., Cerda, S., Andrews, C., Gower, A., Bushell, K., Amar, S., Leeman, S., Becker, J. Inflamm. Bowel Dis. (2006) [Pubmed]
  4. SIMPLE mutation in demyelinating neuropathy and distribution in sciatic nerve. Bennett, C.L., Shirk, A.J., Huynh, H.M., Street, V.A., Nelis, E., Van Maldergem, L., De Jonghe, P., Jordanova, A., Guergueltcheva, V., Tournev, I., Van Den Bergh, P., Seeman, P., Mazanec, R., Prochazka, T., Kremensky, I., Haberlova, J., Weiss, M.D., Timmerman, V., Bird, T.D., Chance, P.F. Ann. Neurol. (2004) [Pubmed]
  5. Inherited neuropathies: from gene to disease. Keller, M.P., Chance, P.F. Brain Pathol. (1999) [Pubmed]
  6. Can inexpensive signs encourage the use of stairs? Results from a community intervention. Andersen, R.E., Franckowiak, S.C., Snyder, J., Bartlett, S.J., Fontaine, K.R. Ann. Intern. Med. (1998) [Pubmed]
  7. Depressive and anxiety disorders in patients presenting with physical complaints: clinical predictors and outcome. Kroenke, K., Jackson, J.L., Chamberlin, J. Am. J. Med. (1997) [Pubmed]
  8. Fatigue, sleep restriction, and performance in automobile drivers: a controlled study in a natural environment. Philip, P., Sagaspe, P., Taillard, J., Moore, N., Guilleminault, C., Sanchez-Ortuno, M., Akerstedt, T., Bioulac, B. Sleep. (2003) [Pubmed]
  9. Smokers with airway obstruction are more likely to quit smoking. Bednarek, M., Gorecka, D., Wielgomas, J., Czajkowska-Malinowska, M., Regula, J., Mieszko-Filipczyk, G., Jasionowicz, M., Bijata-Bronisz, R., Lempicka-Jastrzebska, M., Czajkowski, M., Przybylski, G., Zielinski, J. Thorax (2006) [Pubmed]
  10. Performance of osteoporosis risk assessment tools in postmenopausal women aged 45-64 years. Gourlay, M.L., Miller, W.C., Richy, F., Garrett, J.M., Hanson, L.C., Reginster, J.Y. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2005) [Pubmed]
  11. Perspectives: epidemiology. Simple rules with complex dynamics. May, R. Science (2000) [Pubmed]
  12. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Tang, X., Marciano, D.L., Leeman, S.E., Amar, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Mapping of Charcot-Marie-Tooth disease type 1C to chromosome 16p identifies a novel locus for demyelinating neuropathies. Street, V.A., Goldy, J.D., Golden, A.S., Tempel, B.L., Bird, T.D., Chance, P.F. Am. J. Hum. Genet. (2002) [Pubmed]
  14. Clomid for unexplained infertility? Simple lie or complicated truth? Mersol-Barg, M.S., Dlugi, A.M. Fertil. Steril. (1994) [Pubmed]
  15. Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Daperno, M., D'Haens, G., Van Assche, G., Baert, F., Bulois, P., Maunoury, V., Sostegni, R., Rocca, R., Pera, A., Gevers, A., Mary, J.Y., Colombel, J.F., Rutgeerts, P. Gastrointest. Endosc. (2004) [Pubmed]
  16. Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection. Hahn, M., Fennerty, M.B., Corless, C.L., Magaret, N., Lieberman, D.A., Faigel, D.O. Gastrointest. Endosc. (2000) [Pubmed]
  17. Lessons learned--15 years of the WHO-NCTB: a review. Anger, W.K., Liang, Y.X., Nell, V., Kang, S.K., Cole, D., Bazylewicz-Walczak, B., Rohlman, D.S., Sizemore, O.J. Neurotoxicology (2000) [Pubmed]
  18. Prevalence of abnormal neurobehavioral scores in populations exposed to different industrial chemicals. Camerino, D., Cassitto, M.G., Gilioli, R. Environmental research. (1993) [Pubmed]
  19. Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE. Beauvais, K., Furby, A., Latour, P. Neuromuscul. Disord. (2006) [Pubmed]
  20. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Myokai, F., Takashiba, S., Lebo, R., Amar, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  21. Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease. Meggouh, F., de Visser, M., Arts, W.F., De Coo, R.I., van Schaik, I.N., Baas, F. Ann. Neurol. (2005) [Pubmed]
  22. Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. Street, V.A., Bennett, C.L., Goldy, J.D., Shirk, A.J., Kleopa, K.A., Tempel, B.L., Lipe, H.P., Scherer, S.S., Bird, T.D., Chance, P.F. Neurology (2003) [Pubmed]
  23. Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. Moriwaki, Y., Begum, N.A., Kobayashi, M., Matsumoto, M., Toyoshima, K., Seya, T. J. Biol. Chem. (2001) [Pubmed]
  24. A Simple Method for Kinetic Control of DNA-Induced Nanoparticle Assembly. Maye, M.M., Nykypanchuk, D., van der Lelie, D., Gang, O. J. Am. Chem. Soc. (2006) [Pubmed]
  25. 24-hour mean pulse. Simple predictor of doxorubicin-induced cardiac damage. Hrushesky, W.J., Vukelich, M., Steiner, B., Dell, I., Mukai, K. Am. J. Med. (1984) [Pubmed]
  26. The Mannich Reaction of Malonates with Simple Imines Catalyzed by Bifunctional Cinchona Alkaloids: Enantioselective Synthesis of beta-Amino Acids. Song, J., Wang, Y., Deng, L. J. Am. Chem. Soc. (2006) [Pubmed]
  27. Racial differences in the correlation between gonadal androgens and serum insulin levels. Kitabchi, A.E., Imseis, R.E., Bush, A.J., Williams-Cleaves, B., Pourmotabbed, G. Diabetes Care (1999) [Pubmed]
  28. Identification and functional characterization of a novel binding site on TNF-alpha promoter. Tang, X., Fenton, M.J., Amar, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  29. Bivariate flow cytometric analysis of p53 and DNA content in hepatocellular carcinoma. Qiao, L., Wu, P., Ghaleb, A.H., Pizzolo, J.G., Miller, T.B., Melamed, M.R. Anal. Quant. Cytol. Histol. (1994) [Pubmed]
  30. Symptomatic epilepsy in children with poroencephalic cysts secondary to perinatal middle cerebral artery occlusion. Guzzetta, F., Battaglia, D., Di Rocco, C., Caldarelli, M. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (2006) [Pubmed]
  31. Inherited peripheral neuropathy. Keller, M.P., Chance, P.F. Seminars in neurology. (1999) [Pubmed]
  32. Tumor necrosis factor a microsatellite polymorphism is associated with rheumatoid arthritis severity through an interaction with the HLA-DRB1 shared epitope. Mu, H., Chen, J.J., Jiang, Y., King, M.C., Thomson, G., Criswell, L.A. Arthritis Rheum. (1999) [Pubmed]
  33. SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. Shirk, A.J., Anderson, S.K., Hashemi, S.H., Chance, P.F., Bennett, C.L. J. Neurosci. Res. (2005) [Pubmed]
  34. Simple markers for initiating antiretroviral therapy among HIV-infected Ethiopians. Mekonnen, Y., Dukers, N.H., Sanders, E., Dorigo, W., Wolday, D., Schaap, A., Geskus, R.B., Coutinho, R.A., Fontanet, A. AIDS (2003) [Pubmed]
  35. Predicting outcome in severe ulcerative colitis. Travis, S.P., Farrant, J.M., Ricketts, C., Nolan, D.J., Mortensen, N.M., Kettlewell, M.G., Jewell, D.P. Gut (1996) [Pubmed]
  36. Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus. Hollenberg, N.K., Price, D.A., Fisher, N.D., Lansang, M.C., Perkins, B., Gordon, M.S., Williams, G.H., Laffel, L.M. Kidney Int. (2003) [Pubmed]
  37. Biopsy and quantitative hepatobiliary scintigraphy in the evaluation of liver transplantation. Brunot, B., Petras, S., Germain, P., Vinee, P., Constantinesco, A. J. Nucl. Med. (1994) [Pubmed]
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