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Chemical Compound Review

Fraxetin     7,8-dihydroxy-6-methoxy- chromen-2-one

Synonyms: CHEMBL54909, BSPBio_003224, KBioGR_001952, KBioSS_001987, CCG-38759, ...
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Disease relevance of C09265

  • These data suggest that major features of rotenone-induced neurotoxicity are partially mediated by free radical formation and oxidative stress, and that fraxetin partially protects against rotenone toxicity affecting the main protection system of the cells against oxidative injury [1].
  • Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells [2].

High impact information on C09265

  • Of the remaining five, the most potent scavenger was fraxetin (7,8-dihydroxy-6-methoxycoumarin) with an IC50 (concentration producing 50% inhibition) of 2.3 microM in the cytochrome assay and 5.8 microM using NBT [3].
  • Activity and expression of GPx were increased by rotenone and pre-treatment with fraxetin did not modify significantly these levels [1].
  • When cells were preincubated with fraxetin, there was a decrease in the protein levels and activity of both MnSOD and catalase, in comparison with the rotenone treatment [1].
  • The significant enhancement in HSP70 expression at mRNA and protein levels induced by fraxetin was observed by pre-treatment of cells 0.5 h before rotenone insult [1].
  • These results demonstrated the protective action of fraxetin and suggest that it can reduce apoptosis, possibly by decreasing free radical generation in SH-SY5Y cells [4].

Biological context of C09265

  • These results suggest that the natural antioxidants, such as fraxetin, may prevent the apoptotic death of dopaminergic cells induced by rotenone and mediated by oxidative stress [2].
  • Taken together, this study suggested that intracellular GSH appeared to be an important factor in fraxetin-mediated cytoprotection against rotenone-toxicity in SH-SY5Y cells [5].
  • Modifications on antioxidant capacity and lipid peroxidation in mice under fraxetin treatment [6].
  • Fraxetin at 10-100 muM inhibited the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax, whereas no significant change occurred in Bcl-2 levels [5].
  • Treatment of MG-63 cells with fraxetin not only inhibited anti-Fas IgM-induced apoptosis, but also blocked the synergetic effect of anti-Fas IgM with TNF-alpha or IL-1beta on cell death [7].

Anatomical context of C09265

  • By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, we have shown that fraxetin exhibits a significant induction of differentiation in the human osteoblast-like cell line MG-63 [7].
  • Our results indicated that fraxetin stimulated osteoblast differentiation at various stages (from osteoprogenitors to terminally differentiated osteoblasts) [8].

Associations of C09265 with other chemical compounds


Gene context of C09265


  1. Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine. Molina-Jiménez, M.F., Sánchez-Reus, M.I., Cascales, M., Andrés, D., Benedí, J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  2. Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells. Molina-Jiménez, M.F., Sánchez-Reus, M.I., Andres, D., Cascales, M., Benedi, J. Brain Res. (2004) [Pubmed]
  3. Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins. Paya, M., Goodwin, P.A., De Las Heras, B., Hoult, J.R. Biochem. Pharmacol. (1994) [Pubmed]
  4. Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine. Molina-Jimenez, M.F., Sanchez-Reus, M.I., Benedi, J. Eur. J. Pharmacol. (2003) [Pubmed]
  5. Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells. Sánchez-Reus, M.I., Peinado, I.I., Molina-Jiménez, M.F., Benedí, J. Neurosci. Res. (2005) [Pubmed]
  6. Modifications on antioxidant capacity and lipid peroxidation in mice under fraxetin treatment. Martín-Aragón, S., Benedí, J.M., Villar, A.M. J. Pharm. Pharmacol. (1997) [Pubmed]
  7. Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63. Kuo, P.L., Huang, Y.T., Chang, C.H., Chang, J.K. Int. Immunopharmacol. (2006) [Pubmed]
  8. Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines. Kuo, P.L., Huang, Y.T., Chang, C.H., Chang, J.K. Biol. Pharm. Bull. (2006) [Pubmed]
  9. Chemical constituents of Echites hirsuta (Apocynaceae). Chien, M.M., Svoboda, G.H., Schiff, P.L., Slatkin, D.J., Knapp, J.E. Journal of pharmaceutical sciences. (1979) [Pubmed]
  10. Metabolic fate of fraxin administered orally to rats. Yasuda, T., Fukui, M., Nakazawa, T., Hoshikawa, A., Ohsawa, K. J. Nat. Prod. (2006) [Pubmed]
  11. Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress. Fernandez-Puntero, B., Barroso, I., Iglesias, I., Benedí, J., Villar, A. Biol. Pharm. Bull. (2001) [Pubmed]
  12. Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins. Kimura, Y., Okuda, H., Arichi, S., Baba, K., Kozawa, M. Biochim. Biophys. Acta (1985) [Pubmed]
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