Chemical Compound Review:
Fraxetin 7,8-dihydroxy-6-methoxy- chromen-2-one
Synonyms:
CHEMBL54909, BSPBio_003224, KBioGR_001952, KBioSS_001987, CCG-38759, ...
- Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine. Molina-Jiménez, M.F., Sánchez-Reus, M.I., Cascales, M., Andrés, D., Benedí, J. Toxicol. Appl. Pharmacol. (2005)
- Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells. Molina-Jiménez, M.F., Sánchez-Reus, M.I., Andres, D., Cascales, M., Benedi, J. Brain Res. (2004)
- Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins. Paya, M., Goodwin, P.A., De Las Heras, B., Hoult, J.R. Biochem. Pharmacol. (1994)
- Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine. Molina-Jimenez, M.F., Sanchez-Reus, M.I., Benedi, J. Eur. J. Pharmacol. (2003)
- Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells. Sánchez-Reus, M.I., Peinado, I.I., Molina-Jiménez, M.F., Benedí, J. Neurosci. Res. (2005)
- Modifications on antioxidant capacity and lipid peroxidation in mice under fraxetin treatment. Martín-Aragón, S., Benedí, J.M., Villar, A.M. J. Pharm. Pharmacol. (1997)
- Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63. Kuo, P.L., Huang, Y.T., Chang, C.H., Chang, J.K. Int. Immunopharmacol. (2006)
- Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines. Kuo, P.L., Huang, Y.T., Chang, C.H., Chang, J.K. Biol. Pharm. Bull. (2006)
- Chemical constituents of Echites hirsuta (Apocynaceae). Chien, M.M., Svoboda, G.H., Schiff, P.L., Slatkin, D.J., Knapp, J.E. Journal of pharmaceutical sciences. (1979)
- Metabolic fate of fraxin administered orally to rats. Yasuda, T., Fukui, M., Nakazawa, T., Hoshikawa, A., Ohsawa, K. J. Nat. Prod. (2006)
- Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress. Fernandez-Puntero, B., Barroso, I., Iglesias, I., Benedí, J., Villar, A. Biol. Pharm. Bull. (2001)
- Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins. Kimura, Y., Okuda, H., Arichi, S., Baba, K., Kozawa, M. Biochim. Biophys. Acta (1985)