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Chemical Compound Review:

Isostilbene [(Z)-2-phenylethenyl]benzene

Synonyms: cis-Stilbene, Stilbene, (Z)-, S4808_ALDRICH, CHEMBL393702, CCRIS 5932, ...

Ottea, J.A. et al., Pettit, G.R. et al., Oguro, T. et al., Bellucci, G. et al.

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High impact information on cis-Stilbene

Several of the cis-stilbene derivatives were significantly inhibitory against all cell lines used, with potencies comparable to that of the parent 1a [1].
Epoxide hydrolase and glutathione S-transferase activities toward trans- and cis-stilbene oxides were measured in 3 strains of Drosophila melanogaster [2].
Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides [3].
Trans-Stilbene (TS), a mother compound of TSO, did not show such an effect on ODC, while cis-stilbene (CS) induced both ODC and SAMDC [4].

References

Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. Pettit, G.R., Rhodes, M.R., Herald, D.L., Hamel, E., Schmidt, J.M., Pettit, R.K. J. Med. Chem. (2005) [Pubmed]
Patterns of epoxide metabolism by epoxide hydrolase and glutathione S-transferase associated with age and genotype in Drosophila melanogaster. Ottea, J.A., Harshman, L.G., Hammock, B. Mutat. Res. (1987) [Pubmed]
Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides. Bellucci, G., Chiappe, C., Ingrosso, G. Chirality. (1994) [Pubmed]
Comparative studies of the effects of stilbene compounds on hepatic ornithine decarboxylase and S-adenosylmethionine decarboxylase induction in rats. Oguro, T., Yoshida, T., Numazawa, S., Kuroiwa, Y. Life Sci. (1991) [Pubmed]

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