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Gene Review

Amd1  -  adenosylmethionine decarboxylase 1

Rattus norvegicus

Synonyms: AdoMetDC, Amd1a, Amd1b, S-adenosylmethionine decarboxylase proenzyme, SAMDC
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Disease relevance of Amd1


High impact information on Amd1


Chemical compound and disease context of Amd1


Biological context of Amd1


Anatomical context of Amd1


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Regulatory relationships of Amd1


Other interactions of Amd1


Analytical, diagnostic and therapeutic context of Amd1


  1. Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats. Noguchi, Y., Meyer, T., Tiao, G., Fischer, J.E., Hasselgren, P.O. Shock (1996) [Pubmed]
  2. Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation. Cheetham, B.F., Shaw, D.C., Bellett, A.J. Mol. Cell. Biol. (1982) [Pubmed]
  3. Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone). Alhonen-Hongisto, L., Levin, V.A., Marton, L.J. Cancer Res. (1985) [Pubmed]
  4. S-adenosylmethionine decarboxylase activity is decreased in the rat cortex after traumatic brain injury. Henley, C.M., Wey, K., Takashima, A., Mills, C., Granmayeh, E., Krishnappa, I., Robertson, C.S. J. Neurochem. (1997) [Pubmed]
  5. Activation of polyamine biosynthetic decarboxylases during the acute phase response of rat liver. Scalabrino, G., Ferioli, M.E., Piccoletti, R., Bernelli-Zazzera, A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  6. Increased spermidine or spermine level is essential for hepatocyte growth factor-induced DNA synthesis in cultured rat hepatocytes. Higaki, I., Matsui-Yuasa, I., Terakura, M., Kinoshita, H., Otani, S. Gastroenterology (1994) [Pubmed]
  7. Changes in polyamine metabolism of rat liver after administration of D-galactosamine. Favorable effects of putrescine administration on galactosamine-induced hepatic injury. Daikuhara, Y., Tamada, F., Takigawa, M., Takeda, Y., Mori, Y. Gastroenterology (1979) [Pubmed]
  8. Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes. Ravanko, K., Järvinen, K., Paasinen-Sohns, A., Hölttä, E. Cancer Res. (2000) [Pubmed]
  9. Putrescine-dependent invasive capacity of rat ascites hepatoma cells. Ashida, Y., Kido, J., Kinoshita, F., Nishino, M., Shinkai, K., Akedo, H., Inoue, H. Cancer Res. (1992) [Pubmed]
  10. Decreased cytotoxicity of aziridinylbenzoquinone caused by polyamine depletion in 9L rat brain tumor cells in vitro. Alhonen-Hongisto, L., Deen, D.F., Marton, L.J. Cancer Res. (1984) [Pubmed]
  11. Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats. Noguchi, Y., Meyer, T.A., Tiao, G., Ogle, C.K., Fischer, J.E., Hasselgren, P.O. Metab. Clin. Exp. (1996) [Pubmed]
  12. Purification and characterization of some metabolic effects of S-neplanocylmethionine. Keller, B.T., Clark, R.S., Pegg, A.E., Borchardt, R.T. Mol. Pharmacol. (1985) [Pubmed]
  13. Structure and regulation of mammalian S-adenosylmethionine decarboxylase. Pajunen, A., Crozat, A., Jänne, O.A., Ihalainen, R., Laitinen, P.H., Stanley, B., Madhubala, R., Pegg, A.E. J. Biol. Chem. (1988) [Pubmed]
  14. Comparison of androgen regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase gene expression in rodent kidney and accessory sex organs. Crozat, A., Palvimo, J.J., Julkunen, M., Jänne, O.A. Endocrinology (1992) [Pubmed]
  15. Structures and chromosomal localizations of two rat genes encoding S-adenosylmethionine decarboxylase. Pulkka, A., Ihalainen, R., Suorsa, A., Riviere, M., Szpirer, J., Pajunen, A. Genomics (1993) [Pubmed]
  16. Dietary regulation of the activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase in rats. Moore, P., Swendseid, M.E. J. Nutr. (1983) [Pubmed]
  17. Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity. Pegg, A.E. Biochem. J. (1977) [Pubmed]
  18. The influence of cysteine and methionine supplements on polyamine biosynthesis in the rat. Acuff, R.V., Smith, J.T. J. Nutr. (1983) [Pubmed]
  19. Influence of physical exercise on polyamine synthesis in the rat skeletal muscle. Turchanowa, L., Rogozkin, V.A., Milovic, V., Feldkoren, B.I., Caspary, W.F., Stein, J. Eur. J. Clin. Invest. (2000) [Pubmed]
  20. Decreased activity of adrenal S-adenosylmethionine decarboxylase in rats subjected to dopamine agonists, metabolic stress, or bodily immobilization. Ekker, M., Sourkes, T.L. Endocrinology (1987) [Pubmed]
  21. Possible role of glutathione depletion in the induction of rate-limiting enzymes involved in heme degradation and polyamine biosynthesis in the liver of rats. Oguro, T., Yoshida, T., Numazawa, S., Kuroiwa, Y. J. Pharmacobio-dyn. (1990) [Pubmed]
  22. Regulation of the activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in mammary gland and liver of lactating rats. Effects of starvation, prolactin and insulin deficiency. Brosnan, M.E., Ilic, V., Williamson, D.H. Biochem. J. (1982) [Pubmed]
  23. Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine. Byers, T.L., Bush, T.L., McCann, P.P., Bitonti, A.J. Biochem. J. (1991) [Pubmed]
  24. Regulation of S-adenosyl-L-methionine decarboxylase by 1-aminooxy-3-aminopropane: enzyme kinetics and effects on the enzyme activity in cultured cells. Hyvönen, T., Eloranta, T.O. J. Biochem. (1990) [Pubmed]
  25. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta, T.O., Khomutov, A.R., Khomutov, R.M., Hyvönen, T. J. Biochem. (1990) [Pubmed]
  26. Structure and organization of the gene encoding rat S-adenosylmethionine decarboxylase. Pulkka, A., Ihalainen, R., Aatsinki, J., Pajunen, A. FEBS Lett. (1991) [Pubmed]
  27. Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines. Kameji, T., Pegg, A.E. J. Biol. Chem. (1987) [Pubmed]
  28. Polyamine metabolism in regenerating livers from normal and hypocalcemic rats. Walker, P.R., Sikorska, M., Whitfield, J.F. J. Cell. Physiol. (1978) [Pubmed]
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