The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

deoxyuridine     1-[(2R,4S,5R)-4-hydroxy-5...

Synonyms: dURD, Desoxyuridine, PubChem14193, SureCN28844, CHEMBL353955, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of deoxyuridine

  • The abnormality revealed by the dU suppression tests was identical with that found in vitamin-B12 deficiency, but the patients' serum-B12 concentrations were normal [1].

High impact information on deoxyuridine

  • 8 patients who received nitrous oxide and oxygen for 24 h had megaloblastic bone-marrow aspirates and abnormal dU suppression tests at the end of ventilation [1].
  • Increased concentrations of dThd (>3 micromol/L) and dUrd (>5 micromol/L) in plasma or a decrease in buffy coat TP activity to </=8% relative to controls is sufficient to diagnose MNGIE [2].
  • The long exposure group had abnormal dU supression tests and a megaloblastic hematopoiesis [3].
  • The results indicate that when the intracellular folate content falls below 400-600 pg/10(6) cells, lymphocytes exhibit increased 3H-TdR incorporation into DNA, raised dU-suppressed values, an increase in cell volume and abnormal DNA synthesis [4].
  • This was investigated, using the deoxyuridine (dU) suppression test, in 48 patients admitted to an Intensive Care Unit (ICU) [5].

Chemical compound and disease context of deoxyuridine

  • On admission to the ICU, following nitrous oxide anaesthesia, the pattern of correction of the abnormal dU-suppression tests was typical of that seen in vitamin B12 deficiency; 3 days later the pattern had changed to that usually seen in folate deficiency [5].

Anatomical context of deoxyuridine

  • In this work, we report that infusion of platelets from healthy donors to patients with MNGIE restored transiently circulating TP and reduced plasma dThd and dUrd levels, suggesting that treatments to achieve permanent restoration of circulating TP such as allogeneic stem cell transplantation or gene transfer might be therapeutic [6].

Associations of deoxyuridine with other chemical compounds


  1. Megaloblastic haemopoiesis in patients receiving nitrous oxide. Amess, J.A., Burman, J.F., Rees, G.M., Nancekievill, D.G., Mollin, D.L. Lancet (1978) [Pubmed]
  2. Definitive diagnosis of mitochondrial neurogastrointestinal encephalomyopathy by biochemical assays. Martí, R., Spinazzola, A., Tadesse, S., Nishino, I., Nishigaki, Y., Hirano, M. Clin. Chem. (2004) [Pubmed]
  3. Human bone marrow biochemical function and megaloblastic hematopoiesis after nitrous oxide anesthesia. O'Sullivan, H., Jennings, F., Ward, K., McCann, S., Scott, J.M., Weir, D.G. Anesthesiology (1981) [Pubmed]
  4. Acquired folate deficiency in phytohaemagglutinin-stimulated human lymphocytes. Matthews, J.H., Wickramasinghe, S.N. Br. J. Haematol. (1986) [Pubmed]
  5. Investigations into the effect of nitrous oxide anaesthesia on folate metabolism in patients receiving intensive care. Amos, R.J., Amess, J.A., Hinds, C.J., Mollin, D.L. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1985) [Pubmed]
  6. Infusion of platelets transiently reduces nucleoside overload in MNGIE. Lara, M.C., Weiss, B., Illa, I., Madoz, P., Massuet, L., Andreu, A.L., Valentino, M.L., Anikster, Y., Hirano, M., Mart??, R. Neurology (2006) [Pubmed]
  7. Limited value of serum holo-transcobalamin II measurements in the differential diagnosis of macrocytosis. Wickramasinghe, S.N., Ratnayaka, I.D. J. Clin. Pathol. (1996) [Pubmed]
WikiGenes - Universities