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Chemical Compound Review:

Diamine Blue tetrasodium(3E)-5-amino-3- [[4-[4-[(2E)-2...

Synonyms:

Tăban, S. et al., Kalme, S.D. et al., Kennelly, J.C. et al., Kennelly, J.C. et al., Hughes, R.B. et al., et al.

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Disease relevance of Diamine Blue

Thirteen-week subchronic toxicity studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 dyes [1].
Pseudomonas desmolyticum NCIM 2112 was able to degrade a diazo dye Direct Blue-6 (100mgl(-1)) completely within 72h of incubation with 88.95% reduction in COD in static anoxic condition [2].
This study is based upon the interpretation of 130 gastric biopsies in which the identification of H. pylori was pursued (by HE staining, Giemsa), o intestinal metaplasia and their types (by PAS-Blue Alcian ph 2.5 staining and High Iron Diamine-Blue Alcian ph 2.5) and the presence of neoplastic lesions [3].

High impact information on Diamine Blue

Both body fluids were analysed for reduction products which were found only in the case of direct black 38, direct brown 95 and direct blue 6 [4].
This adduct may form as a result of the susceptibility of the dye to hepatic azoreductase and its apparent existence may explain the observed potent carcinogenicity of dyes such as Direct Blue 6 [5].
Biodegradation of benzidine based dye Direct Blue-6 by Pseudomonas desmolyticum NCIM 2112 [2].
The use of Fast Blue 2B salt greatly enhances the specificity of the TLC analysis of suspected marihuana samples [6].

References

Thirteen-week subchronic toxicity studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 dyes. Robens, J.F., Dill, G.S., Ward, J.M., Joiner, J.R., Griesemer, R.A., Douglas, J.F. Toxicol. Appl. Pharmacol. (1980) [Pubmed]
Biodegradation of benzidine based dye Direct Blue-6 by Pseudomonas desmolyticum NCIM 2112. Kalme, S.D., Parshetti, G.K., Jadhav, S.U., Govindwar, S.P. Bioresour. Technol. (2007) [Pubmed]
Intestinal metaplasia and dysplastic modifications in H. pylori gastritis. Tăban, S., Tudose, N. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. (1996) [Pubmed]
The release of 4,4'-diaminobiphenyls from azodyes in the rat. Kennelly, J.C., Hertzog, P.J., Martin, C.N. Carcinogenesis (1982) [Pubmed]
Reduction to benzidine is not necessary for the covalent binding of a benzidine azodye to rat liver DNA. Kennelly, J.C., Shaw, A., Martin, C.N. Toxicology (1984) [Pubmed]
Increased safety and specificity in the thin-layer chromatographic identification of marihuana. Hughes, R.B., Kessler, M.S., Kessler, R.R. J. Forensic Sci. (1979) [Pubmed]

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