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MeSH Review

Body Fluids

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Disease relevance of Body Fluids


Psychiatry related information on Body Fluids


High impact information on Body Fluids

  • The hypothalamo-neurohypophysial system plays a fundamental role in the maintenance of body fluid homeostasis by secreting vasopressin and oxytocin in response to osmotic and nonosmotic stimuli [11].
  • Angiotensin II also plays an important role in the regulation of body fluids, being a potent inducer of thirst and, in general, antagonizes the actions of ANP [11].
  • Klf4-/- mice die shortly after birth due to loss of skin barrier function, as measured by penetration of external dyes and rapid loss of body fluids [12].
  • This test detects as little as 3 ng of the p30 antigen per milliliter in various body fluids [13].
  • However, the antigen cannot be detected in body fluids from women, including vaginal fluid and urine, suggesting that p30 may be a male-specific antigen [13].

Chemical compound and disease context of Body Fluids


Biological context of Body Fluids


Anatomical context of Body Fluids


Associations of Body Fluids with chemical compounds


Gene context of Body Fluids

  • Binding proteins for insulin-like growth factors (IGFs) IGF-I and IGF-II, known as IGFBPs, control the distribution, function and activity of IGFs in various cell tissues and body fluids [34].
  • Adenylosuccinate lyase (ADSL) deficiency (MIM 103050) is an autosomal recessive inborn error of purine synthesis characterized by the accumulation in body fluids of succinylaminoimidazolecarboxamide (SAICA) riboside and succinyladenosine (S-Ado), the dephosphorylated derivatives of the two substrates of the enzyme [35].
  • Because clusterin is an abundant protein in the body fluid in tissues, it may act as a negative regulator of MT6-MMP in vivo [36].
  • Thus, increased COMP levels in body fluids may be indicative of active synovitis as well as of accelerated joint erosion [37].
  • Soluble CD97alpha was found in body fluids from inflamed tissues, suggesting that a functional consequence of the CD97 heterodimeric structure is the stable existence of CD97alpha in a cellfree form [38].

Analytical, diagnostic and therapeutic context of Body Fluids


  1. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. Clerici, M., Levin, J.M., Kessler, H.A., Harris, A., Berzofsky, J.A., Landay, A.L., Shearer, G.M. JAMA (1994) [Pubmed]
  2. "Endogenous" benzodiazepine activity in body fluids of patients with hepatic encephalopathy. Mullen, K.D., Szauter, K.M., Kaminsky-Russ, K. Lancet (1990) [Pubmed]
  3. Functions of angiotensin in the central nervous system. Phillips, M.I. Annu. Rev. Physiol. (1987) [Pubmed]
  4. Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis. Crooks, D.M., Pacheco-Rodriguez, G., DeCastro, R.M., McCoy, J.P., Wang, J.A., Kumaki, F., Darling, T., Moss, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Effects of vasopressin on the circulation and its baroreflex control in healthy men. Aylward, P.E., Floras, J.S., Leimbach, W.N., Abboud, F.M. Circulation (1986) [Pubmed]
  6. Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ. Nomura, M., Ueta, Y., Larsen, P.J., Hannibal, J., Serino, R., Kabashima, N., Shibuya, I., Yamashita, H. Endocrinology (1997) [Pubmed]
  7. Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome. Harper, R.G., Solish, G., Feingold, E., Gersten-Woolf, N.B., Sokal, M.M. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  8. Neuropeptide Y, peptide YY and aluminum in Alzheimer's disease: is there an etiological relationship? Croom, J., Taylor, I.L. J. Inorg. Biochem. (2001) [Pubmed]
  9. Cocaine in body fluids: analysis and interpretation of the drug abuse specimen. Martin, H.F. Rhode Island medical journal. (1990) [Pubmed]
  10. The safety needle switchover, part 2 of 2. Steed, C., Baker, M. Nursing management. (2002) [Pubmed]
  11. Neuroendocrine control of body fluid metabolism. Antunes-Rodrigues, J., de Castro, M., Elias, L.L., Valença, M.M., McCann, S.M. Physiol. Rev. (2004) [Pubmed]
  12. Klf4 is a transcription factor required for establishing the barrier function of the skin. Segre, J.A., Bauer, C., Fuchs, E. Nat. Genet. (1999) [Pubmed]
  13. Postcoital detection of a male-specific semen protein. Application to the investigation of rape. Graves, H.C., Sensabaugh, G.F., Blake, E.T. N. Engl. J. Med. (1985) [Pubmed]
  14. Selection of a monoclonal antibody reactive with a high-molecular-weight glycoprotein circulating in the body fluid of gastrointestinal cancer patients. Sakurai, Y., Hirohashi, S., Shimosato, Y., Kodaira, S., Abe, O. Cancer Res. (1988) [Pubmed]
  15. Disorders of body fluids, sodium and potassium in chronic renal failure. Mitch, W.E., Wilcox, C.S. Am. J. Med. (1982) [Pubmed]
  16. Role of angiotensin converting enzyme inhibitors in essential and renal hypertension. Effects of captopril and enalapril on renin-angiotensin-aldosterone, renal function and hemodynamics, salt and water excretion, and body fluid composition. Bauer, J.H. Am. J. Med. (1984) [Pubmed]
  17. Effect of successful treatment with amphotericin B on Histoplasma capsulatum variety capsulatum polysaccharide antigen levels in patients with AIDS and histoplasmosis. Wheat, L.J., Connolly-Stringfield, P., Blair, R., Connolly, K., Garringer, T., Katz, B.P., Gupta, M. Am. J. Med. (1992) [Pubmed]
  18. Development of a skin-based metabolic sink for phenylalanine by overexpression of phenylalanine hydroxylase and GTP cyclohydrolase in primary human keratinocytes. Christensen, R., Kolvraa, S., Blaese, R.M., Jensen, T.G. Gene Ther. (2000) [Pubmed]
  19. Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit. van den Heuvel, L., Ruitenbeek, W., Smeets, R., Gelman-Kohan, Z., Elpeleg, O., Loeffen, J., Trijbels, F., Mariman, E., de Bruijn, D., Smeitink, J. Am. J. Hum. Genet. (1998) [Pubmed]
  20. Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying. Anand Kumar, T.C., David, G.F., Sankaranarayanan, A., Puri, V., Sundram, K.R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  21. Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro. Homburg, C.H., de Haas, M., von dem Borne, A.E., Verhoeven, A.J., Reutelingsperger, C.P., Roos, D. Blood (1995) [Pubmed]
  22. Osmotic regulation of neuronal activity: a new role for taurine and glial cells in a hypothalamic neuroendocrine structure. Hussy, N., Deleuze, C., Desarménien, M.G., Moos, F.C. Prog. Neurobiol. (2000) [Pubmed]
  23. Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats. Park, K.S., Kim, J.H., Kim, M.S., Kim, J.M., Kim, S.K., Choi, J.Y., Chung, M.H., Han, B., Kim, S.Y., Lee, H.K. Diabetes (2001) [Pubmed]
  24. Cross-linking of fibronectin to collagen by blood coagulation Factor XIIIa. Mosher, D.F., Schad, P.E. J. Clin. Invest. (1979) [Pubmed]
  25. Intrapulmonary heparin. A new procedure for anticoagulant therapy. Jaques, L.B., Mahadoo, J., Kavanagh, L.W. Lancet (1976) [Pubmed]
  26. Dopamine metabolism and disposition in schizophrenic patients. Studies using debrisoquin. Maas, J.W., Contreras, S.A., Seleshi, E., Bowden, C.L. Arch. Gen. Psychiatry (1988) [Pubmed]
  27. Ethylmalonic encephalopathy is caused by mutations in ETHE1, a gene encoding a mitochondrial matrix protein. Tiranti, V., D'Adamo, P., Briem, E., Ferrari, G., Mineri, R., Lamantea, E., Mandel, H., Balestri, P., Garcia-Silva, M.T., Vollmer, B., Rinaldo, P., Hahn, S.H., Leonard, J., Rahman, S., Dionisi-Vici, C., Garavaglia, B., Gasparini, P., Zeviani, M. Am. J. Hum. Genet. (2004) [Pubmed]
  28. Ascitic fluid chemical analysis before, during and after spontaneous bacterial peritonitis. Runyon, B.A., Hoefs, J.C. Hepatology (1985) [Pubmed]
  29. A mouse model for the human lysosomal disease aspartylglycosaminuria. Kaartinen, V., Mononen, I., Voncken, J.W., Noronkoski, T., Gonzalez-Gomez, I., Heisterkamp, N., Groffen, J. Nat. Med. (1996) [Pubmed]
  30. Markers for detection of supplementation in narcotic programs--deuterium-labeled methadone. Hsia, J.C., Tam, J.C., Giles, H.G., Leung, C.C., Marcus, H., Marshman, J.A., Leblanc, A.E. Science (1976) [Pubmed]
  31. Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice. Legator, M.S., Connor, T.H., Stoeckel, M. Science (1975) [Pubmed]
  32. Dipstick: quick quantitation of ethanol in body fluids. Wetmore, K. JAMA (1983) [Pubmed]
  33. Blood volume and body fluid compartments in lambs with aortopulmonary left-to-right shunts. Gratama, J.W., Dalinghaus, M., Meuzelaar, J.J., Gerding, A.M., Koers, J.H., Zijlstra, W.G., Kuipers, J.R. J. Clin. Invest. (1992) [Pubmed]
  34. Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C., Lang, K., Holak, T.A. EMBO J. (1998) [Pubmed]
  35. Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency. Race, V., Marie, S., Vincent, M.F., Van den Berghe, G. Hum. Mol. Genet. (2000) [Pubmed]
  36. Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils. Matsuda, A., Itoh, Y., Koshikawa, N., Akizawa, T., Yana, I., Seiki, M. J. Biol. Chem. (2003) [Pubmed]
  37. Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes. Recklies, A.D., Baillargeon, L., White, C. Arthritis Rheum. (1998) [Pubmed]
  38. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. Gray, J.X., Haino, M., Roth, M.J., Maguire, J.E., Jensen, P.N., Yarme, A., Stetler-Stevenson, M.A., Siebenlist, U., Kelly, K. J. Immunol. (1996) [Pubmed]
  39. Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids. Waring, P., Wycherley, K., Cary, D., Nicola, N., Metcalf, D. J. Clin. Invest. (1992) [Pubmed]
  40. Bile acid profiles in peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency. Clayton, P.T., Patel, E., Lawson, A.M., Carruthers, R.A., Collins, J. J. Clin. Invest. (1990) [Pubmed]
  41. Fate of radioactive exocrine pancreatic proteins injected into the blood circulation of the rat. Tissue uptake and transepithelial excretion. Rohr, G., Scheele, G. Gastroenterology (1983) [Pubmed]
  42. A soluble form of Fc gamma RIII is present in human serum and other body fluids and is elevated at sites of inflammation. Fleit, H.B., Kobasiuk, C.D., Daly, C., Furie, R., Levy, P.C., Webster, R.O. Blood (1992) [Pubmed]
  43. Isolation and characterization of a putative endogenous benzodiazepineoid (endozepine) from bovine and human brain. Shoyab, M., Gentry, L.E., Marquardt, H., Todaro, G.J. J. Biol. Chem. (1986) [Pubmed]
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