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Chemical Compound Review

AC1NSFPO     disodium 2-[[[(2R,3S)-2...

Synonyms: 586366_ALDRICH, [2S-[2alpha,3alpha(Z)
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Disease relevance of


High impact information on

  • The pharmacokinetics of carumonam (AMA-1080) were studied after a single intravenous 1.0-g dose was given to 26 subjects grouped according to their renal functions [3].
  • The in vitro activity of carumonam (Ro 17-2301; AMA-1080) was tested against 355 single-patient isolates, by and large enteropathogenic or nonfermentative rods [4].
  • It was found that AMA-1080 was highly resistant to hydrolysis by both chromosomal and plasmid-mediated beta-lactamases [2].

Biological context of


Analytical, diagnostic and therapeutic context of


  1. Single-dose pharmacokinetics of Ro 17-2301 (AMA-1080), a monocyclic beta-lactam, in humans. Weidekamm, E., Stoeckel, K., Egger, H.J., Ziegler, W.H. Antimicrob. Agents Chemother. (1984) [Pubmed]
  2. In-vitro antibacterial activity of AMA-1080. Matsuda, K., Hamana, Y., Inoue, M., Mitsuhashi, S. J. Antimicrob. Chemother. (1985) [Pubmed]
  3. Pharmacokinetics of carumonam (AMA-1080) in patients with impaired renal function and in those undergoing hemodialysis. Konishi, K., Suzuki, H., Saruta, T., Deguchi, N., Fugono, T. Antimicrob. Agents Chemother. (1991) [Pubmed]
  4. In vitro activity of carumonam (Ro 17-2301; AMA-1080) versus enteropathogenic and nonfermentative gram-negative rods and Legionella pneumophila. Hohl, P., von Graevenitz, A., Zollinger-Iten, J. Antimicrob. Agents Chemother. (1988) [Pubmed]
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