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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In-vitro antibacterial activity of AMA-1080.

The in-vitro antibacterial activity of AMA-1080 against both Gram-positive and Gram-negative clinical isolates was studied in comparison with that of aztreonam, cefotaxime, ceftazidime and cefoperazone. AMA-1080 showed a potent antibacterial activity against Gram-negative bacteria, particularly, the strains of Enterobacteriaceae. In addition, AMA-1080 inhibited the strains of genus Pseudomonas at the low concentrations. However, AMA-1080 showed less active against Gram-positive bacteria. It was found that AMA-1080 was highly resistant to hydrolysis by both chromosomal and plasmid-mediated beta-lactamases.[1]


  1. In-vitro antibacterial activity of AMA-1080. Matsuda, K., Hamana, Y., Inoue, M., Mitsuhashi, S. J. Antimicrob. Chemother. (1985) [Pubmed]
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