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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

LEWISITE     dichloro-[(E)-2- chloroethenyl]arsane

Synonyms: Lewisite 1, Lewisite I, AC1NSYZH, Lewisite (L-1), CCRIS 4122, ...
 
 
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Disease relevance of Lewisite I

 

High impact information on Lewisite I

  • The robustness of this approach was illustrated by successful identification of Lewisite I in samples from the Sixth Proficiency Test (organised by the Organisation for the Prohibition of Chemical Weapons, OPCW) in a matrix of 1 mg ml(-1) diesel oil [2].
  • TNF-alpha expression patterns as potential molecular biomarker for human skin cells exposed to vesicant chemical warfare agents: sulfur mustard (HD) and Lewisite (L) [3].
  • An acute head-only inhalation study was conducted in rats exposed for 1 h to product solution (wastestream) resultant from the chemical neutralization of Chemical Agent Identification Sets (CAIS) containing agent (sulfur mustard (HD), nitrogen mustard (HN-1) or lewisite (L)) in chloroform [4].

References

  1. Laminin in the cutaneous basement membrane as a potential target in lewisite vesication. King, J.R., Peters, B.P., Monteiro-Riviere, N.A. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  2. Analysis of chemical warfare agents. I. Use of aliphatic thiols in the trace level determination of Lewisite compounds in complex matrices. Muir, B., Slater, B.J., Cooper, D.B., Timperley, C.M. Journal of chromatography. A. (2004) [Pubmed]
  3. TNF-alpha expression patterns as potential molecular biomarker for human skin cells exposed to vesicant chemical warfare agents: sulfur mustard (HD) and Lewisite (L). Arroyo, C.M., Burman, D.L., Kahler, D.W., Nelson, M.R., Corun, C.M., Guzman, J.J., Smith, M.A., Purcell, E.D., Hackley, B.E., Soni, S.D., Broomfield, C.A. Cell Biol. Toxicol. (2004) [Pubmed]
  4. Acute inhalation toxicity of neutralized chemical agent identification sets (CAIS) containing agent in chloroform. Olajos, E.J., Morgan, E.W., Renne, R.A., Salem, H., McVeety, B., Johnson, R., Phelps, R.L. Journal of applied toxicology : JAT. (1998) [Pubmed]
 
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