Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AG-F-32294 4-hydroxy-N-[2-[2-(1-methyl- 2...

Synonyms: SureCN11265684, MJ-9444, LS-26987, CTK1A9467, LS-185014, ...

Libersa, C. et al., Winkle, R.A. et al., Dresel, P.E.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of O-Desmethyl-encainide

MJ 9444 (0.05-0.4 mg/kg) speeded Purkinje conduction of early (less than 300 msec) without affecting or while slowing conduction of late (greater than 350 msec) extrasystoles [1].
At the time of arrhythmia return encainide was generally no longer detectable but the average concentration of O-demethylencainide and 3 methoxy-O-demethylencainide was 72 +/- 49 and 172 +/- 74 ng/ml, respectively [2].

High impact information on O-Desmethyl-encainide

The intracellular electrophysiologic effects of encainide (E) and its main metabolite, O-desmethyl-encainide (ODE), were studied in guinea-pig papillary muscle preparations and related to the in-vivo electrophysiologic effects observed after intravenous (IV) infusion of E in 11 patients undergoing electrophysiologic study (EPS) [3].

References

Effect of encainide and its two major metabolites on cardiac conduction. Dresel, P.E. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
Possible contribution of encainide metabolites to the long-term antiarrhythmic efficacy of encainide. Winkle, R.A., Peters, F., Kates, R.E., Harrison, D.C. Am. J. Cardiol. (1983) [Pubmed]
In-vitro and in-vivo electrophysiologic effects of encainide. Libersa, C., Caron, J., Rouet, R. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share