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MeSH Review

Cardiac Complexes, Premature

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Disease relevance of Cardiac Complexes, Premature


Psychiatry related information on Cardiac Complexes, Premature

  • The patient had serious psychiatric problems; the ventricular premature beats were provoked by psychophysiologic stress, increased during REM sleep, were reduced by meditation, and were controlled by beta-adrenergic blockade, phenytoin and digitalization [6].

High impact information on Cardiac Complexes, Premature


Chemical compound and disease context of Cardiac Complexes, Premature


Biological context of Cardiac Complexes, Premature


Anatomical context of Cardiac Complexes, Premature

  • In the rat coronary artery ligation model, disopyramide (class I), amefalone and melperone significantly (P less than 0.05) reduced the number of extrasystoles [20].
  • The accelerated inactivation time course of HERG/MiRP1(V65M) channels may decrease I(Kr) current density of myocardial cells, thereby impairing the ability of myocytes to repolarize in response to sudden membrane depolarizations such as extrasystoles [21].
  • Accuracy of the value <0 msec (obtained by subtracting the time interval between high right atrium and His-bundle atrial activation during atrial premature beats from that obtained during sinus rhythm) for discriminating the superior vena cava or upper portion of the crista terminalis from the pulmonary vein (PV) foci was 100% [22].
  • On the other hand, low doses of lidocaine caused speeding of early extrasystoles, i.e., coupling intervals (less than 250 ms) in the Purkinje system but not in the myocardium [23].
  • Lithium and KBR effects particularly for the extrasystole can be explained through the inhibition of Ca entry via Na-Ca exchange giving support to the participation of the Na-Ca exchanger in the Ca influx from the extracellular space [24].

Gene context of Cardiac Complexes, Premature

  • The plasma ANP level was significantly higher in patients with rather than without PAF attacks (75 +/- 41 vs. 54 +/- 60 pg/ml, p = 0.01), although there were no significant differences in age, left atrial dimension or high grade atrial premature beats between the groups [25].
  • Prognostic significance of heart rate turbulence following ventricular premature beats in patients with idiopathic dilated cardiomyopathy [26].
  • Patients with COPD had higher rate of ventricular premature beats (VPBs) as compared to control subjects (924 +/- 493 beats vs 35 +/- 23 beats, p = 0.009) [27].
  • Isolated ventricular premature beats and runs of slow ventricular rhythm with H(2)O(2) more frequently occurred in HF compared to SHAM despite an increased antioxidant capacity including Cu/Zn and Mn superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase [28].
  • However, with the addition of each successive premature beat, the HPS-RRP of the postextrasystolic beat alternated between lower and higher values, in a manner dependent on whether there was an odd or even number of premature beats [29].

Analytical, diagnostic and therapeutic context of Cardiac Complexes, Premature


  1. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Mohler, P.J., Schott, J.J., Gramolini, A.O., Dilly, K.W., Guatimosim, S., duBell, W.H., Song, L.S., Haurogné, K., Kyndt, F., Ali, M.E., Rogers, T.B., Lederer, W.J., Escande, D., Le Marec, H., Bennett, V. Nature (2003) [Pubmed]
  2. Cardiac disorders in penicillin-induced anaphylaxis. Association with intravenous epinephrine therapy. Sullivan, T.J. JAMA (1982) [Pubmed]
  3. Enalapril decreases prevalence of ventricular tachycardia in patients with chronic congestive heart failure. The V-HeFT II VA Cooperative Studies Group. Fletcher, R.D., Cintron, G.B., Johnson, G., Orndorff, J., Carson, P., Cohn, J.N. Circulation (1993) [Pubmed]
  4. The response to overdrive pacing of triggered atrial and ventricular arrhythmias in the canine heart. Malfatto, G., Rosen, T.S., Rosen, M.R. Circulation (1988) [Pubmed]
  5. Lidocaine and His bundle extrasystoles. His bundle discharge conducted with functional right of left bundle-branch block, or blocked entirely (concealed). Bonner, A.J., Zipes, D.P. Arch. Intern. Med. (1976) [Pubmed]
  6. Basis for recurring ventricular fibrillation in the absence of coronary heart disease and its management. Lown, B., Temte, J.V., Reich, P., Gaughan, C., Regestein, Q., Hal, H. N. Engl. J. Med. (1976) [Pubmed]
  7. Effect of a digitalis drug on ventricular premature beats. Lown, B., Graboys, T.B., Podrid, P.J., Cohen, B.H., Stockman, M.B., Gaughan, C.E. N. Engl. J. Med. (1977) [Pubmed]
  8. Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias. Harada, K., Komuro, I., Hayashi, D., Sugaya, T., Murakami, K., Yazaki, Y. Circulation (1998) [Pubmed]
  9. Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction. Hondeghem, L., Katzung, B.G. Circulation (1980) [Pubmed]
  10. Muscarinic effects of vagosympathetic trunk stimulation on the repetitive extrasystole (RE) threshold. Rabinowitz, S.H., Verrier, R.L., Lown, B. Circulation (1976) [Pubmed]
  11. Long-term follow-up of right ventricular monomorphic extrasystoles. Gaita, F., Giustetto, C., Di Donna, P., Richiardi, E., Libero, L., Brusin, M.C., Molinari, G., Trevi, G. J. Am. Coll. Cardiol. (2001) [Pubmed]
  12. Comparison of intravenous lorcainide with lidocaine for acute therapy of complex ventricular arrhythmias: results of a randomized study with crossover option. Anderson, J.L., Anastasiou-Nana, M., Lutz, J.R., Writer, S.L. J. Am. Coll. Cardiol. (1985) [Pubmed]
  13. Electrophysiologic effects of sodium channel blockade on anisotropic conduction and conduction block in canine myocardium: preferential slowing of longitudinal conduction by flecainide versus disopyramide or lidocaine. Kondo, T., Yamaki, M., Kubota, I., Tachibana, H., Tomoike, H. J. Am. Coll. Cardiol. (1997) [Pubmed]
  14. Effects of lidocaine, procainamide, metoprolol, digoxin and atropine on the conduction of premature ventricular beats in man. Edvardsson, N., Hirsch, I., Olsson, S.B. Eur. Heart J. (1985) [Pubmed]
  15. Effect of peri-operative diltiazem on myocardial ischaemia and function in patients receiving mammary artery grafts. Hannes, W., Seitelberger, R., Christoph, M., Keilich, M., Kulinna, C., Holubarsch, C., Fasol, R. Eur. Heart J. (1995) [Pubmed]
  16. Evaluation of pentisomide on stable ventricular premature beats. Comparison with placebo. Mangini, S.G., Mastropasqua, F., Oldani, V., Massari, F., Maino, G.N., Ricci, A., Scrutinio, D., Rizzon, P. Eur. Heart J. (1991) [Pubmed]
  17. Hydrogen peroxide modifies the kinetics of HERG channel expressed in a mammalian cell line. Bérubé, J., Caouette, D., Daleau, P. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  18. Cardiac and hemodynamic tolerability of iopromide with or without sodium or iloprost and of ioversol in the anesthetized rat. Krause, W., Muschick, P., Wehrmann, D. Investigative radiology. (1994) [Pubmed]
  19. Volumetric cine CMR to quantify atrial structure and function in patients with atrial dysrhythmias. Raman, S.V., Ng, V.Y., Neff, M.A., Sayar, S., Sparks, E.A., Nelson, S.D., Ferketich, A.K., Wooley, C.F. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. (2005) [Pubmed]
  20. Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents. Brooks, R.R., Miller, K.E., Carpenter, J.F., Jones, S.M. Proc. Soc. Exp. Biol. Med. (1989) [Pubmed]
  21. Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics. Isbrandt, D., Friederich, P., Solth, A., Haverkamp, W., Ebneth, A., Borggrefe, M., Funke, H., Sauter, K., Breithardt, G., Pongs, O., Schulze-Bahr, E. J. Mol. Med. (2002) [Pubmed]
  22. Predicting the arrhythmogenic foci of atrial fibrillation before atrial transseptal procedure: implication for catheter ablation. Lee, S.H., Tai, C.T., Lin, W.S., Tsai, C.F., Hsieh, M.H., Yu, W.C., Lin, Y.K., Chen, C.C., Ding, Y.A., Chang, M.S., Chen, S.A. J. Cardiovasc. Electrophysiol. (2000) [Pubmed]
  23. Effects of lidocaine on conduction of extrasystoles in the normal canine heart. Carson, D.L., Dresel, P.E. J. Cardiovasc. Pharmacol. (1981) [Pubmed]
  24. Lithium and KB-R7943 effects on mechanics and energetics of rat heart muscle. Bonazzola, P., Egido, P., Marengo, F.D., Savio-Galimberti, E., Ponce-Hornos, J.E. Acta Physiol. Scand. (2002) [Pubmed]
  25. Prediction of paroxysmal atrial fibrillation in patients with congestive heart failure: a prospective study. Yamada, T., Fukunami, M., Shimonagata, T., Kumagai, K., Ogita, H., Asano, Y., Hirata, A., Masatsugu, H., Hoki, N. J. Am. Coll. Cardiol. (2000) [Pubmed]
  26. Prognostic significance of heart rate turbulence following ventricular premature beats in patients with idiopathic dilated cardiomyopathy. Grimm, W., Schmidt, G., Maisch, B., Sharkova, J., Müller, H.H., Christ, M. J. Cardiovasc. Electrophysiol. (2003) [Pubmed]
  27. Ventricular arrhythmias in patients with COPD are associated with QT dispersion. Yildiz, P., Tükek, T., Akkaya, V., Sözen, A.B., Yildiz, A., Korkut, F., Yilmaz, V. Chest (2002) [Pubmed]
  28. Ventricular arrhythmias following exposure of failing hearts to oxidative stress in vitro. Brigadeau, F., Gelé, P., Marquié, C., Soudan, B., Lacroix, D. J. Cardiovasc. Electrophysiol. (2005) [Pubmed]
  29. Behavior of postextrasystolic His-Purkinje system refractoriness after multiple premature beats. Tchou, P., Lehmann, M.H., Mahmud, R., Dongas, J., Denker, S., Akhtar, M. J. Lab. Clin. Med. (1988) [Pubmed]
  30. Antiarrhythmic efficacy and tolerance of oral propafenone in patients with frequent ventricular arrhythmias: experience of a multicentre study. Geibel, A., Meinertz, T., Zehender, M., Vitak, J., Hohnloser, S., Kunz-Fritze, A., Just, H. Eur. Heart J. (1989) [Pubmed]
  31. The effects of timolol on arrhythmias and prostanoid release during canine myocardial ischaemia and reperfusion. Coker, S.J., Parratt, J.R. Br. J. Pharmacol. (1984) [Pubmed]
  32. Cardiac effects of formoterol and salmeterol in patients suffering from COPD with preexisting cardiac arrhythmias and hypoxemia. Cazzola, M., Imperatore, F., Salzillo, A., Di Perna, F., Calderaro, F., Imperatore, A., Matera, M.G. Chest (1998) [Pubmed]
  33. Arrhythmias in children prenatally exposed to cocaine. Frassica, J.J., Orav, E.J., Walsh, E.P., Lipshultz, S.E. Archives of pediatrics & adolescent medicine. (1994) [Pubmed]
  34. Signal-averaged ECG in prediction of the short-term suppression of ventricular premature beats by Mexiletine. Zaliunas, R., Zabiela, P., Slapikas, R., Vainoras, A., Pentiokiniene, D., Levisauskiene, R., Bechtold, H., Meyer, U. International journal of cardiology. (1994) [Pubmed]
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