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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Lophirone A     3-[1-(2,4-dihydroxyphenyl)- 3,3-bis(4...

Synonyms: AC1NUQWJ, CCRIS 5445, 110383-39-6
 
 
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Disease relevance of CCRIS 5445

  • Lophirone A, isolated as a new type of biflavonoid-related inhibitor of Epstein-Barr virus (EBV) activation, was tested for further inhibitory properties against tumor promotion by short-term system [1].
 

High impact information on CCRIS 5445

  • Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4'',5'',6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa [2].
  • Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo [1].

References

  1. Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo. Murakami, A., Ohigashi, H., Jisaka, M., Hirota, M., Irie, R., Koshimizu, K. Cancer Lett. (1991) [Pubmed]
  2. Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L. Anuradha, V., Srinivas, P.V., Ranga Rao, R., Manjulatha, K., Purohit, M.G., Madhusudana Rao, J. Bioorg. Med. Chem. (2006) [Pubmed]
 
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