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Chemical Compound Review

Crysophanol     1,8-dihydroxy-3-methyl- anthracene-9,10-dione

Synonyms: Chrysophanol, Chrysophanein, SPECTRUM300545, S2406_Selleck, SureCN308131, ...
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Disease relevance of Crysophanic acid


High impact information on Crysophanic acid


Chemical compound and disease context of Crysophanic acid

  • We have detected the bioactive anthraquinone chrysophanol, which serves as a chemical defense in diverse eukaryotic organisms, in a bacterial Nocardia strain, thereby permitting the first comparative biosynthetic study [9].

Associations of Crysophanic acid with other chemical compounds


Gene context of Crysophanic acid


  1. Mutagenicity of islandicin and chrysophanol in the Salmonella/microsome system. Liberman, D.F., Schaefer, F.L., Fink, R.C., Ramgopal, M., Ghosh, A.C., Mulcahy, R. Appl. Environ. Microbiol. (1980) [Pubmed]
  2. No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol. Mengs, U., Schuler, D., Marshall, R.R. Mutat. Res. (2001) [Pubmed]
  3. Anthraquinone cytotoxicity and apoptosis in primary cultures of rat hepatocytes. Kågedal, K., Bironaite, D., Ollinger, K. Free Radic. Res. (1999) [Pubmed]
  4. In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Semple, S.J., Pyke, S.M., Reynolds, G.D., Flower, R.L. Antiviral Res. (2001) [Pubmed]
  5. Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Wölfle, D., Schmutte, C., Westendorf, J., Marquardt, H. Cancer Res. (1990) [Pubmed]
  6. Novel type of potential anticancer agents derived from chrysophanol and emodin. Some structure-activity relationship studies. Koyama, M., Kelly, T.R., Watanabe, K.A. J. Med. Chem. (1988) [Pubmed]
  7. Determination of five anthraquinones in medicinal plants by capillary zone electrophoresis with beta-cyclodextrin addition. Tian, K., Zhang, H., Chen, X., Hu, Z. Journal of chromatography. A. (2006) [Pubmed]
  8. Electrophoretic behavior study and determination of some active components in Chinese medicinal preparations by capillary electrophoresis. Liu, H.T., Wang, K.T., Zhang, H.Y., Chen, X.G., Hu, Z.D. The Analyst. (2000) [Pubmed]
  9. Different polyketide folding modes converge to an identical molecular architecture. Bringmann, G., Noll, T.F., Gulder, T.A., Grüne, M., Dreyer, M., Wilde, C., Pankewitz, F., Hilker, M., Payne, G.D., Jones, A.L., Goodfellow, M., Fiedler, H.P. Nat. Chem. Biol. (2006) [Pubmed]
  10. Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites. Mueller, S.O., Stopper, H., Dekant, W. Drug Metab. Dispos. (1998) [Pubmed]
  11. Defensive Components in Insect Eggs: Are Anthraquinones Produced during Egg Development? Pankewitz, F., Hilker, M. J. Chem. Ecol. (2006) [Pubmed]
  12. Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L. Anuradha, V., Srinivas, P.V., Ranga Rao, R., Manjulatha, K., Purohit, M.G., Madhusudana Rao, J. Bioorg. Med. Chem. (2006) [Pubmed]
  13. Constituents of Ruscus aculeatus. ElSohly, M., Knapp, J.E., Slatkin, K.F., Schiff, P.L., Doorenbos, N.J., Quimby, M.W. Lloydia. (1975) [Pubmed]
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