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Chemical Compound Review

CHEMBL17432     5-benzyl-1-(2- hydroxyethoxymethyl) pyrimidi...

Synonyms: AG-H-31407, SureCN7558156, CHEBI:41037, CHEBI:119634, CTK3E8940, ...
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Disease relevance of Benzylacyclouridine


High impact information on Benzylacyclouridine


Biological context of Benzylacyclouridine


Associations of Benzylacyclouridine with other chemical compounds


  1. Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. Calabresi, P., Falcone, A., St Clair, M.H., Wiemann, M.C., Chu, S.H., Darnowski, J.W. Blood (1990) [Pubmed]
  2. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. Liu, M., Cao, D., Russell, R., Handschumacher, R.E., Pizzorno, G. Cancer Res. (1998) [Pubmed]
  3. Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine. Martin, D.S., Stolfi, R.L., Sawyer, R.C. Cancer Chemother. Pharmacol. (1989) [Pubmed]
  4. Uridine phosphorylase association with vimentin. Intracellular distribution and localization. Russell, R.L., Cao, D., Zhang, D., Handschumacher, R.E., Pizzorno, G. J. Biol. Chem. (2001) [Pubmed]
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  6. Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils. Orr, G.F., Musso, D.L., Boswell, G.E., Kelley, J.L., Joyner, S.S., Davis, S.T., Baccanari, D.P. J. Med. Chem. (1995) [Pubmed]
  7. Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine. Chu, M.Y., Naguib, F.N., Iltzsch, M.H., el Kouni, M.H., Chu, S.H., Cha, S., Calabresi, P. Cancer Res. (1984) [Pubmed]
  8. Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation. Cao, D., Pizzorno, G. Drugs of today (Barcelona, Spain : 1998) (2004) [Pubmed]
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