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Gene Review

Upp1  -  uridine phosphorylase 1

Mus musculus

Synonyms: AI325217, UPase, UPase 1, UdRPase, Up, ...
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Disease relevance of Upp1


High impact information on Upp1


Chemical compound and disease context of Upp1


Biological context of Upp1


Anatomical context of Upp1

  • Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines [1].
  • Through transient expression analysis of the 5'-flanking region of UPase gene, we have evaluated the promoter activity for a series of fragments with 5'- to 3'-deletion in murine breast cancer EMT-6 cells and immortalized murine fibroblast NIH 3T3 cells [10].

Associations of Upp1 with chemical compounds


Other interactions of Upp1


Analytical, diagnostic and therapeutic context of Upp1


  1. Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cao, D., Russell, R.L., Zhang, D., Leffert, J.J., Pizzorno, G. Cancer Res. (2002) [Pubmed]
  2. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. Liu, M., Cao, D., Russell, R., Handschumacher, R.E., Pizzorno, G. Cancer Res. (1998) [Pubmed]
  3. Purification, cloning, and expression of murine uridine phosphorylase. Watanabe, S., Hino, A., Wada, K., Eliason, J.F., Uchida, T. J. Biol. Chem. (1995) [Pubmed]
  4. Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-5-benzyluracil and its amino analogue, new potent uridine phosphorylase inhibitors with high water solubility. Lin, T.S., Liu, M.C. J. Med. Chem. (1985) [Pubmed]
  5. Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine. Ishitsuka, H., Miwa, M., Takemoto, K., Fukuoka, K., Itoga, A., Maruyama, H.B. Gann = Gan. (1980) [Pubmed]
  6. Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Kim, S., Denny, C.T., Wisdom, R. Mol. Cell. Biol. (2006) [Pubmed]
  7. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Haraguchi, M., Tsujimoto, H., Fukushima, M., Higuchi, I., Kuribayashi, H., Utsumi, H., Nakayama, A., Hashizume, Y., Hirato, J., Yoshida, H., Hara, H., Hamano, S., Kawaguchi, H., Furukawa, T., Miyazono, K., Ishikawa, F., Toyoshima, H., Kaname, T., Komatsu, M., Chen, Z.S., Gotanda, T., Tachiwada, T., Sumizawa, T., Miyadera, K., Osame, M., Yoshida, H., Noda, T., Yamada, Y., Akiyama, S. Mol. Cell. Biol. (2002) [Pubmed]
  8. Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. Cao, D., Nimmakayalu, M.A., Wang, F., Zhang, D., Handschumacher, R.E., Bray-Ward, P., Pizzorno, G. Cancer Res. (1999) [Pubmed]
  9. Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. Cao, D., Leffert, J.J., McCabe, J., Kim, B., Pizzorno, G. J. Biol. Chem. (2005) [Pubmed]
  10. p53-dependent suppression of uridine phosphorylase gene expression through direct promoter interaction. Zhang, D., Cao, D., Russell, R., Pizzorno, G. Cancer Res. (2001) [Pubmed]
  11. Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine. Chu, M.Y., Naguib, F.N., Iltzsch, M.H., el Kouni, M.H., Chu, S.H., Cha, S., Calabresi, P. Cancer Res. (1984) [Pubmed]
  12. Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside. Ashour, O.M., Naguib, F.N., Khalifa, M.M., Abdel-Raheem, M.H., Panzica, R.P., el Kouni, M.H. Cancer Res. (1995) [Pubmed]
  13. Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Zhang, Y., Repa, J.J., Inoue, Y., Hayhurst, G.P., Gonzalez, F.J., Mangelsdorf, D.J. Mol. Endocrinol. (2004) [Pubmed]
  14. Uridine-5'-phosphate synthase: evidence for substrate cycling involving this bifunctional protein. Traut, T.W. Arch. Biochem. Biophys. (1989) [Pubmed]
  15. Pyrimidine salvage pathways in Toxoplasma gondii. Iltzsch, M.H. J. Eukaryot. Microbiol. (1993) [Pubmed]
  16. Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10. Ashour, O.M., Naguib, F.N., Goudgaon, N.M., Schinazi, R.F., el Kouni, M.H. Biochem. Pharmacol. (2000) [Pubmed]
  17. Tissue uridine pools: evidence in vivo of a concentrative mechanism for uridine uptake. Darnowski, J.W., Handschumacher, R.E. Cancer Res. (1986) [Pubmed]
  18. Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils. Orr, G.F., Musso, D.L., Boswell, G.E., Kelley, J.L., Joyner, S.S., Davis, S.T., Baccanari, D.P. J. Med. Chem. (1995) [Pubmed]
  19. 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration. Implications for chemotherapy. Ashour, O.M., Naguib, F.N., el Kouni, M.H. Biochem. Pharmacol. (1996) [Pubmed]
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