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Gene Review

Tymp  -  thymidine phosphorylase

Mus musculus

Synonyms: 2900072D10Rik, Ecgf1, PD-ECGF, PDECGF, Pdgfec, ...
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Disease relevance of Ecgf1


High impact information on Ecgf1


Chemical compound and disease context of Ecgf1


Biological context of Ecgf1


Anatomical context of Ecgf1

  • L-dRib anti-invasive activity may be mediated by its ability to suppress the enhancing effect of TP and D-dRib on both mRNA and protein expression of vascular endothelial growth factor and interleukin-8 in cultured KB cells [5].
  • Next, we compared the ability of L-dRib and tegafur alone or in combination to decrease the number of metastatic nodules in organs in the abdominal cavity in nude mice receiving s.c. of KB/TP cells into their backs [5].
  • We investigated the effects of 2'-deoxyinosine (d-Ino), a modulator yielding thymidine phosphorylase activity, on cellular pharmacology of 5-fluorouracil (FUra) in various human colorectal cell lines and its antitumoral activity when combined with FUra in human xenografts [12].
  • A novel endogenous polypeptide inhibitor of proliferation and DNA synthesis in glial cells, gliostatin, was purified from the extracts of neurofibroma by a procedure comprising dye and anion-exchange column chromatography, and HPLC [13].
  • To estimate the mechanism of FdUrd efficacy, thymidine phosphorylase (TPase) and thymidine kinase (TK), key enzymes in the metabolism of FdUrd, were measured in rat, mouse and normal human brain tissue, and in human brain tumor tissues and cerebrospinal fluid (CSF) from patients with malignant brain tumors including meningeal carcinomatosis [14].

Associations of Ecgf1 with chemical compounds


Other interactions of Ecgf1


Analytical, diagnostic and therapeutic context of Ecgf1


  1. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Haraguchi, M., Tsujimoto, H., Fukushima, M., Higuchi, I., Kuribayashi, H., Utsumi, H., Nakayama, A., Hashizume, Y., Hirato, J., Yoshida, H., Hara, H., Hamano, S., Kawaguchi, H., Furukawa, T., Miyazono, K., Ishikawa, F., Toyoshima, H., Kaname, T., Komatsu, M., Chen, Z.S., Gotanda, T., Tachiwada, T., Sumizawa, T., Miyadera, K., Osame, M., Yoshida, H., Noda, T., Yamada, Y., Akiyama, S. Mol. Cell. Biol. (2002) [Pubmed]
  2. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease. Rampazzo, C., Gallinaro, L., Milanesi, E., Frigimelica, E., Reichard, P., Bianchi, V. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Suppression of metastasis by thymidine phosphorylase inhibitor. Takao, S., Akiyama, S.I., Nakajo, A., Yoh, H., Kitazono, M., Natsugoe, S., Miyadera, K., Fukushima, M., Yamada, Y., Aikou, T. Cancer Res. (2000) [Pubmed]
  4. Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy. Seeliger, H., Guba, M., Koehl, G.E., Doenecke, A., Steinbauer, M., Bruns, C.J., Wagner, C., Frank, E., Jauch, K.W., Geissler, E.K. Clin. Cancer Res. (2004) [Pubmed]
  5. Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Nakajima, Y., Gotanda, T., Uchimiya, H., Furukawa, T., Haraguchi, M., Ikeda, R., Sumizawa, T., Yoshida, H., Akiyama, S. Cancer Res. (2004) [Pubmed]
  6. Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication. Balzarini, J., McGuigan, C. J. Antimicrob. Chemother. (2002) [Pubmed]
  7. Enhancement of the anti-tumor effect of 5'-deoxy-5-fluorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells. Kanyama, H., Tomita, N., Yamano, T., Miyoshi, Y., Ohue, M., Fujiwara, Y., Sekimoto, M., Sakita, I., Tamaki, Y., Monden, M. Jpn. J. Cancer Res. (1999) [Pubmed]
  8. Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Blanquicett, C., Gillespie, G.Y., Nabors, L.B., Miller, C.R., Bharara, S., Buchsbaum, D.J., Diasio, R.B., Johnson, M.R. Mol. Cancer Ther. (2002) [Pubmed]
  9. The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors. Matsushita, S., Nitanda, T., Furukawa, T., Sumizawa, T., Tani, A., Nishimoto, K., Akiba, S., Miyadera, K., Fukushima, M., Yamada, Y., Yoshida, H., Kanzaki, T., Akiyama, S. Cancer Res. (1999) [Pubmed]
  10. Suppression of tumor growth and downregulation of platelet-derived endothelial cell growth factor / thymidine phosphorylase in tumor cells by angiogenesis inhibitor TNP-470. Mori, J., Haisa, M., Naomoto, Y., Takaoka, M., Kimura, M., Yamatsuji, T., Notohara, K., Tanaka, N. Jpn. J. Cancer Res. (2000) [Pubmed]
  11. Combination of oral fluoropyrimidine and docetaxel: reappraisal of synergistic effect against gastric carcinoma xenografts. Kodera, Y., Fujiwara, M., Yokoyama, H., Ohashi, N., Miura, S., Ito, Y., Koike, M., Ito, K., Nakao, A. In Vivo (2005) [Pubmed]
  12. Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts. Ciccolini, J., Peillard, L., Evrard, A., Cuq, P., Aubert, C., Pelegrin, A., Formento, P., Milano, G., Catalin, J. Clin. Cancer Res. (2000) [Pubmed]
  13. A novel glial growth inhibitory factor, gliostatin, derived from neurofibroma. Asai, K., Hirano, T., Kaneko, S., Moriyama, A., Nakanishi, K., Isobe, I., Eksioglu, Y.Z., Kato, T. J. Neurochem. (1992) [Pubmed]
  14. Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study. Nakagawa, H., Yamada, M., Fukushima, M., Ikenaka, K. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  15. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. Liu, M., Cao, D., Russell, R., Handschumacher, R.E., Pizzorno, G. Cancer Res. (1998) [Pubmed]
  16. Relationship between p53 status and 5-fluorouracil sensitivity in 3 cell lines. Oka, H., Ikeda, K., Yoshimura, H., Ohuchida, A., Honma, M. Mutat. Res. (2006) [Pubmed]
  17. Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside. Ashour, O.M., Naguib, F.N., Khalifa, M.M., Abdel-Raheem, M.H., Panzica, R.P., el Kouni, M.H. Cancer Res. (1995) [Pubmed]
  18. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Ishikawa, T., Sekiguchi, F., Fukase, Y., Sawada, N., Ishitsuka, H. Cancer Res. (1998) [Pubmed]
  19. Trichinella spiralis and Trichinella pseudospiralis: developmental patterns of enzymes involved in thymidylate biosynthesis and pyrimidine salvage. Rode, W., Dabrowska, M., Zieliński, Z., Gołos, B., Wranicz, M., Felczak, K., Kulikowski, T. Parasitology (2000) [Pubmed]
  20. Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects. Blanquicett, C., Saif, M.W., Buchsbaum, D.J., Eloubeidi, M., Vickers, S.M., Chhieng, D.C., Carpenter, M.D., Sellers, J.C., Russo, S., Diasio, R.B., Johnson, M.R. Clin. Cancer Res. (2005) [Pubmed]
  21. Analytical and pharmacokinetic studies with 5-chloro-2'-deoxycytidine. Hale, J.T., Bigelow, J.C., Mathews, L.A., McCormack, J.J. Biochem. Pharmacol. (2002) [Pubmed]
  22. Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts. Yamamoto, S., Kurebayashi, J., Kurosumi, M., Kunisue, H., Otsuki, T., Tanaka, K., Sonoo, H. Cancer Chemother. Pharmacol. (2001) [Pubmed]
  23. Pyrimidine nucleotide metabolism in human colon carcinomas: comparison of normal tissues, primary tumors and xenografts. Luccioni, C., Beaumatin, J., Bardot, V., Lefrançois, D. Int. J. Cancer (1994) [Pubmed]
  24. Anti-metastatic effect of capecitabine on human colon cancer xenografts in nude mouse rectum. Ninomiya, I., Terada, I., Yoshizumi, T., Takino, T., Nagai, N., Morita, A., Fushida, S., Nishimura, G., Fujimura, T., Ohta, T., Miwa, K. Int. J. Cancer (2004) [Pubmed]
  25. Immunohistochemical localization of thymidine phosphorylase in gastric cancer: is there a role of the differential expression in tumor cells and associated stromal cells? Liakakos, T., Troupis, T., Ghiconti, I., Triantafyllidis, S., Macheras, A., Karatzas, G., Pavlakis, K. Anticancer Res. (2006) [Pubmed]
  26. The expression of thymidine phosphorylase is a prognostic predictor for the intravesical recurrence of superficial bladder cancer. Nonomura, N., Nakai, Y., Nakayama, M., Inoue, H., Nishimura, K., Hatanaka, E., Arima, R., Kishimoto, T., Miki, T., Kuroda, H., Okuyama, A. Int. J. Clin. Oncol. (2006) [Pubmed]
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