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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1LBKJE     1,2,5-thiadiazole

Synonyms: SureCN27767, SureCN413531, AG-K-07286, CHEBI:39469, KST-1B2744, ...
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High impact information on Piazthiole


Gene context of Piazthiole

  • Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs [6].


  1. 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. Ward, J.S., Merritt, L., Calligaro, D.O., Bymaster, F.P., Shannon, H.E., Mitch, C.H., Whitesitt, C., Brunsting, D., Sheardown, M.J., Olesen, P.H., Swedberg, M.D., Jeppesen, L., Sauerberg, P. J. Med. Chem. (1998) [Pubmed]
  2. Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity. Sauerberg, P., Jeppesen, L., Olesen, P.H., Rasmussen, T., Swedberg, M.D., Sheardown, M.J., Fink-Jensen, A., Thomsen, C., Thøgersen, H., Rimvall, K., Ward, J.S., Calligaro, D.O., DeLapp, N.W., Bymaster, F.P., Shannon, H.E. J. Med. Chem. (1998) [Pubmed]
  3. Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome. Mitch, C.H., Brown, T.J., Bymaster, F.P., Calligaro, D.O., Dieckman, D., Merrit, L., Peters, S.C., Quimby, S.J., Shannon, H.E., Shipley, L.A., Ward, J.S., Hansen, K., Olesen, P.H., Sauerberg, P., Sheardown, M.J., Swedberg, M.D., Suzdak, P., Greenwood, B. J. Med. Chem. (1997) [Pubmed]
  4. 1,2,5-thiadiazole 1-oxide and 1,1-dioxide derivatives. A new class of potent histamine H2-receptor antagonists. Algieri, A.A., Luke, G.M., Standridge, R.T., Brown, M., Partyka, R.A., Crenshaw, R.R. J. Med. Chem. (1982) [Pubmed]
  5. 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors. Sabb, A.L., Vogel, R.L., Kelly, M.G., Palmer, Y., Smith, D.L., Andree, T.H., Schechter, L.E. Bioorg. Med. Chem. Lett. (2001) [Pubmed]
  6. Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs. Sauerberg, P., Olesen, P.H., Sheardown, M.J., Suzdak, P.D., Shannon, H.E., Bymaster, F.P., Calligaro, D.O., Mitch, C.H., Ward, J.S., Swedberg, M.D. Life Sci. (1995) [Pubmed]
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