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Gene Review

Hrh2  -  histamine receptor H 2

Rattus norvegicus

Synonyms: Gastric receptor I, H2R, HH2R, Histamine H2 receptor
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Analytical, diagnostic and therapeutic context of Hrh2


  1. Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. Yu, Y., Kawarai, M., Koss, M.C. Eur. J. Pharmacol. (2001) [Pubmed]
  2. Capsaicin-sensitive vagal afferent fibers do not contribute to histamine H2 receptor agonist-induced gastric acid secretion in anesthetized rats. Yoneda, M., Raybould, H.E. Eur. J. Pharmacol. (1990) [Pubmed]
  3. Involvement of central cholinergic muscarinic receptors and histamine H1 receptors in hyperglycemia induced by prostaglandin F2 alpha in rats. Nonogaki, K., Iguchi, A., Zhu, L.X., Kunoh, Y., Tamagawa, T., Sakamoto, N. Neuroendocrinology (1993) [Pubmed]
  4. Thrombin functions as an inflammatory mediator through activation of its receptor. Cirino, G., Cicala, C., Bucci, M.R., Sorrentino, L., Maraganore, J.M., Stone, S.R. J. Exp. Med. (1996) [Pubmed]
  5. Oral administration of synthetic human urogastrone promotes healing of chronic duodenal ulcers in rats. Skov Olsen, P., Poulsen, S.S., Therkelsen, K., Nexø, E. Gastroenterology (1986) [Pubmed]
  6. Sleep variables are unaltered by zolantidine in rats: are histamine H2-receptors not involved in sleep regulation? Monti, J.M., Orellana, C., Boussard, M., Jantos, H., Olivera, S. Brain Res. Bull. (1990) [Pubmed]
  7. The effects of cimetidine on schedule-controlled responding and locomotor activity in rats. Rastogi, S.K., McMillan, D.E. Pharmacol. Biochem. Behav. (1984) [Pubmed]
  8. A histaminergic H2-receptor antagonist, ranitidine, blocks the suppressive vasopressin response to fear-related emotional stress in the rat. Onaka, T., Yagi, K. Neurosci. Res. (1992) [Pubmed]
  9. Central H1 and H2 receptor participation in the control of water and salt intake in rats. Magrani, J., de Castro e Silva, E., Ramos, A.C., Athanazio, R., Barbetta, M., Fregoneze, J.B. Physiol. Behav. (2005) [Pubmed]
  10. Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems. Ackerman, S.H. Science (1982) [Pubmed]
  11. Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells. Differential effects mediated by histamine H1 and H2 receptors. Sedor, J.R., Abboud, H.E. J. Clin. Invest. (1985) [Pubmed]
  12. Gastrin-stimulated changes in Ca2+ concentration in parietal cells depends on adenosine 3',5'-cyclic monophosphate levels. Geibel, J., Abraham, R., Modlin, I., Sachs, G. Gastroenterology (1995) [Pubmed]
  13. Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats. Tsunada, S., Fujimoto, K., Gotoh, Y., Sakai, T., Kang, M., Sakata, T., Granger, D.N., Tso, P. Gastroenterology (1994) [Pubmed]
  14. Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. Poynter, D., Pick, C.R., Harcourt, R.A., Selway, S.A., Ainge, G., Harman, I.W., Spurling, N.W., Fluck, P.A., Cook, J.L. Gut (1985) [Pubmed]
  15. Antisecretory and antiulcer effect of the H2-receptor antagonist famotidine in the rat: comparison with ranitidine. Scarpignato, C., Tramacere, R., Zappia, L. Br. J. Pharmacol. (1987) [Pubmed]
  16. Clonidine-induced hypotension: further evidence for a central interaction with histamine H2 receptor antagonists in the rat. Finch, L., Harvey, C.A., Hicks, P.E., Owen, D.A. Neuropharmacology (1978) [Pubmed]
  17. Mechanism of oxmetidine (SK&F 92994) cytotoxicity in isolated rat hepatocytes. Rush, G.F., Ripple, M., Chenery, R. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  18. Cloning and tissue expression of a rat histamine H2-receptor gene. Ruat, M., Traiffort, E., Arrang, J.M., Leurs, R., Schwartz, J.C. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  19. A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine. Main, I.H., Whittle, B.J. J. Physiol. (Lond.) (1976) [Pubmed]
  20. Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro. Brown, R.E., Reymann, K.G. J. Physiol. (Lond.) (1996) [Pubmed]
  21. Histamine H3 receptor-mediated modulation of water consumption in the rat. Clapham, J., Kilpatrick, G.J. Eur. J. Pharmacol. (1993) [Pubmed]
  22. Effect of H1 and H2 receptor antagonists on the serum activity of gamma-glutamyltransferase during liver regeneration after partial hepatectomy in rats. Kozlowski, V.A., Mattos Filho, T.R. Pharmacology (1995) [Pubmed]
  23. Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. Stark, H., Purand, K., Ligneau, X., Rouleau, A., Arrang, J.M., Garbarg, M., Schwartz, J.C., Schunack, W. J. Med. Chem. (1996) [Pubmed]
  24. Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats. Sharma, H.S., Nyberg, F., Cervos-Navarro, J., Dey, P.K. Neuroscience (1992) [Pubmed]
  25. Influence of hormonal treatment on the response of the rat isolated uterus to histamine and histamine receptor agonists. Rubio, E., Estañ, L.A., Morales-Olivas, F.J., Martinez-Mir, I. Eur. J. Pharmacol. (1992) [Pubmed]
  26. Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist. Chairungsrilerd, N., Furukawa, K., Ohta, T., Nozoe, S., Ohizumi, Y. Eur. J. Pharmacol. (1996) [Pubmed]
  27. Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed. Adeagbo, A.S., Oriowo, M.A. Eur. J. Pharmacol. (1998) [Pubmed]
  28. Neurotensin hyperglycemia:evidence for histamine mediation and the assessment of a possible physiologic role. Nagai, K., Frohman, L.A. Diabetes (1978) [Pubmed]
  29. The effects of histamine H2 receptor antagonists on androgen action in vivo and dihydrotestosterone binding to the rat prostate androgen receptor in vitro. Sivelle, P.C., Underwood, A.H., Jelly, J.A. Biochem. Pharmacol. (1982) [Pubmed]
  30. Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist. Kawanishi, Y., Ishihara, S., Takahashi, K., Tsushima, T., Hagishita, S., Ishikawa, M., Ishihara, Y. Chem. Pharm. Bull. (1997) [Pubmed]
  31. Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata. Tutton, P.J., Barkla, D.H. Cell Biol. Int. Rep. (1978) [Pubmed]
  32. Involvement of oxytocin in histamine- and stress-induced ACTH and prolactin secretion. Kjaer, A., Knigge, U., Warberg, J. Neuroendocrinology (1995) [Pubmed]
  33. Histamine H1 and H2 receptor activation stimulates ACTH and beta-endorphin secretion by increasing corticotropin-releasing hormone in the hypophyseal portal blood. Kjaer, A., Knigge, U., Plotsky, P.M., Bach, F.W., Warberg, J. Neuroendocrinology (1992) [Pubmed]
  34. Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine. Bamforth, S.D., Lightman, S.L., Greenwood, J. Am. J. Pathol. (1997) [Pubmed]
  35. Activation of histidine decarboxylase by H2-receptor blockade: mechanism of action. Häkanson, R., Hedenbro, J., Liedberg, G., Rehfeld, J.F., Stadil, F. Br. J. Pharmacol. (1975) [Pubmed]
  36. Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism. da Silva, W.C., Bonini, J.S., Bevilaqua, L.R., Izquierdo, I., Cammarota, M. Neurobiology of learning and memory. (2006) [Pubmed]
  37. Characterization of histamine-induced contraction in rat isolated aorta. Schoeffter, P., Godfraind, T. Eur. J. Pharmacol. (1991) [Pubmed]
  38. Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat. Liao, W., Rudling, M., Möller, C., Angelin, B. Eur. J. Pharmacol. (1999) [Pubmed]
  39. A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Ruat, M., Traiffort, E., Arrang, J.M., Tardivel-Lacombe, J., Diaz, J., Leurs, R., Schwartz, J.C. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  40. Alteration by histamine-receptor blockers of the potentiation of angiotensin I in the pulmonary vascular bed. Ercan, Z.S. Arzneimittel-Forschung. (1980) [Pubmed]
  41. Effects of zolantidine a brain-penetrating H2-receptor antagonist, on naloxone-sensitive and naloxone-resistant analgesia. Gogas, K.R., Hough, L.B. Neuropharmacology (1988) [Pubmed]
  42. Histamine excites noradrenergic neurons in locus coeruleus in rats. Korotkova, T.M., Sergeeva, O.A., Ponomarenko, A.A., Haas, H.L. Neuropharmacology (2005) [Pubmed]
  43. Histamine participates in the early phase of trabecular bone loss in ovariectomized rats. Lesclous, P., Guez, D., Baroukh, B., Vignery, A., Saffar, J.L. Bone (2004) [Pubmed]
  44. Inhibition of granulation tissue growth by histamine. Saeki, K., Yokoyama, J., Wake, K. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
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