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Chemical Compound Review

Sublinox     (2R,3R)-2,3- dihydroxybutanedioic acid; N,N...

Synonyms: Bikalm, BEMA-Zolpidem, Zolpidem MR, Zolpidem ODT, OX-22, ...
 
 
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  • Zolpidem tartrate had no effect on exploratory activity (staircase test) or motor performance (rotarod test) in gamma2I77/I77 mice at doses up to 30 mg/kg (i.p.) that strongly sedated or impaired the control mice [6].
  • All subjects received a 5 mg oral dose of zolpidem tartrate, followed by multiple blood samples that were assayed by HPLC with fluorescence detection [7].

References

  1. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. Nowell, P.D., Mazumdar, S., Buysse, D.J., Dew, M.A., Reynolds, C.F., Kupfer, D.J. JAMA (1997) [Pubmed]
  2. Zolpidem tartrate and somnambulism. Harazin, J., Berigan, T.R. Military medicine. (1999) [Pubmed]
  3. Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors. Sancar, F., Ericksen, S.S., Kucken, A.M., Teiss??re, J.A., Czajkowski, C. Mol. Pharmacol. (2007) [Pubmed]
  4. Treatment of inferior lateral pterygoid muscle dystonia with zolpidem tartrate, botulinum toxin injections, and physical self-regulation procedures: a case report. Vazquez-Delgado, E., Okeson, J.P. Cranio : the journal of craniomandibular practice. (2004) [Pubmed]
  5. Zolpidem: a nonbenzodiazepine hypnotic for treatment of insomnia. Hoehns, J.D., Perry, P.J. Clinical pharmacy. (1993) [Pubmed]
  6. Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Cope, D.W., Wulff, P., Oberto, A., Aller, M.I., Capogna, M., Ferraguti, F., Halbsguth, C., Hoeger, H., Jolin, H.E., Jones, A., McKenzie, A.N., Ogris, W., Poeltl, A., Sinkkonen, S.T., Vekovischeva, O.Y., Korpi, E.R., Sieghart, W., Sigel, E., Somogyi, P., Wisden, W. Neuropharmacology (2004) [Pubmed]
  7. Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use. Olubodun, J.O., Ochs, H.R., Trüten, V., Klein, A., von Moltke, L.L., Harmatz, J.S., Shader, R.I., Greenblatt, D.J. Journal of clinical pharmacology. (2002) [Pubmed]
 
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