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MeSH Review

Rotarod Performance Test

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Disease relevance of Rotarod Performance Test


Psychiatry related information on Rotarod Performance Test

  • CRA1000 and CRA1001 had no effects on the hexobarbital-induced anesthesia in mice, the rotarod test in mice, the spontaneous locomotor activity in mice, and a passive avoidance task in rats [6].
  • TD50s are usually determined by tests, such as the rotarod test or the chimney test, for quantification of 'minimal neurological deficit', such as motor impairment, while median effective doses are commonly determined in the maximal electroshock seizure (MES) test or the s.c. pentylenetetrazol (PTZ) seizure test in mice or rats [7].
  • The effects of postnatal chronic exposure to this methylxanthine on motor skills and locomotor activity were studied with a battery of motor and behavioral tests (negative geotaxis test, wire mesh ascending test, jumping down with a choice test, bar holding test, rotarod test and open field test) in rats during development [8].

High impact information on Rotarod Performance Test

  • We show here that exactly how the rotarod test is performed can markedly alter the apparent patterns of genetic influence both in undrugged performance and sensitivity to ethanol intoxication [9].
  • There is a good correlation between the apparent affinities of a series of phencyclidine analogs for the phencyclidine receptor and the pharacological activities of these analogs as measured by the rotarod assay [10].
  • CT-1 delayed the onset of motor impairment as assessed in the rotarod test [11].
  • These effects were antagonized by prior injection of the alpha(2)-adrenoceptor antagonist idazoxan (0.5 mg/kg i.v.), but not the opioid receptor antagonist naloxone (0.1 mg/kg i.v.). On the other hand, cizolirtine (10 mg/kg p.o.) produced no motor deficits in animals using the rotarod test [12].
  • In summary, ABT-594 is less potent than (+)-epibatidine in assays of acute and persistent pain and in the rotarod assay [13].

Chemical compound and disease context of Rotarod Performance Test


Anatomical context of Rotarod Performance Test


Associations of Rotarod Performance Test with chemical compounds


Gene context of Rotarod Performance Test

  • RESULTS: Motor co-ordination was significantly impaired in the rotarod test of CCK2R receptor-deficient mice [24].
  • Lis1 mutant mice displayed abnormal hindpaw clutching responses and were impaired on a rotarod test [25].
  • On the rotarod test, however, the mutant mice were significantly more impaired by diazepam (5-20 mg/kg, i.p.), when compared with alpha 6 +/+ control and background C57BL/6J and 129/SvJ mouse lines [26].
  • There were no significant differences between Nas1-/- and Nas1+/+ mice in a rotarod performance test of motor coordination and in the forced swim test assessing (anti-)depressant-like behaviours [27].
  • Motor coordination and equilibrium, as tested in the rotarod test, was impaired in 12-month-old ASA-deficient mice [28].

Analytical, diagnostic and therapeutic context of Rotarod Performance Test


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  2. The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat. Patel, S., Naeem, S., Kesingland, A., Froestl, W., Capogna, M., Urban, L., Fox, A. Pain (2001) [Pubmed]
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  10. Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. Vincent, J.P., Kartalovski, B., Geneste, P., Kamenka, J.M., Lazdunski, M. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  11. Protective effects of cardiotrophin-1 adenoviral gene transfer on neuromuscular degeneration in transgenic ALS mice. Bordet, T., Lesbordes, J.C., Rouhani, S., Castelnau-Ptakhine, L., Schmalbruch, H., Haase, G., Kahn, A. Hum. Mol. Genet. (2001) [Pubmed]
  12. Effects of the novel analgesic, cizolirtine, in a rat model of neuropathic pain. Kayser, V., Farré, A., Hamon, M., Bourgoin, S. Pain (2003) [Pubmed]
  13. Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain. Kesingland, A.C., Gentry, C.T., Panesar, M.S., Bowes, M.A., Vernier, J.M., Cube, R., Walker, K., Urban, L. Pain (2000) [Pubmed]
  14. Comparison of antagonistic effects of sendide and CP-96,345 on a spinally mediated behavioural response in mice. Sakurada, T., Manome, Y., Katsumata, K., Tan-No, K., Sakurada, S., Ohba, M., Kisara, K. Eur. J. Pharmacol. (1994) [Pubmed]
  15. Analysis of anticonvulsant and neurotoxic responses to combination therapy with carbamazepine, felbamate and phenytoin by response-surface modeling. Gennings, C., Sofia, R.D., Carchman, R.A., Carter, W.H., Swinyard, E.A. Arzneimittel-Forschung. (1995) [Pubmed]
  16. Toxic effects of combined exposure to toluene and m-xylene in animals. III. Subchronic inhalation study. Korsak, Z., Sokal, J.A., Górny, R. Polish journal of occupational medicine and environmental health. (1992) [Pubmed]
  17. Effect of nifedipine, a calcium channel inhibitor, on sedation produced by reserpine, clonidine and propranolol in mice. Desai, M.K., Dikshit, R.K., Mansuri, S.M., Shah, U.H. Indian J. Exp. Biol. (1994) [Pubmed]
  18. Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Iancu, R., Mohapel, P., Brundin, P., Paul, G. Behav. Brain Res. (2005) [Pubmed]
  19. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Nadeson, R., Goodchild, C.S. Pain (2000) [Pubmed]
  20. Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. Kayser, V., Christensen, D. Pain (2000) [Pubmed]
  21. Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol. Carroll, F.I., Brine, G.A., Boldt, K.G., Cone, E.J., Yousefnejad, D., Vaupel, D.B., Buchwald, W.F. J. Med. Chem. (1981) [Pubmed]
  22. Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice. Raud, S., Rünkorg, K., Veraksits, A., Reimets, A., Nelovkov, A., Abramov, U., Matsui, T., Bourin, M., Volke, V., Kõks, S., Vasar, E. Psychopharmacology (Berl.) (2003) [Pubmed]
  23. Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats. Kitano, Y., Komiyama, C., Makino, M., Takasuna, K., Takazawa, A., Sakurada, S. Epilepsia (2005) [Pubmed]
  24. Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system. Kõks, S., Volke, V., Veraksits, A., Rünkorg, K., Sillat, T., Abramov, U., Bourin, M., Huotari, M., Männistö, P.T., Matsui, T., Vasar, E. Psychopharmacology (Berl.) (2001) [Pubmed]
  25. Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice. Paylor, R., Hirotsune, S., Gambello, M.J., Yuva-Paylor, L., Crawley, J.N., Wynshaw-Boris, A. Learn. Mem. (1999) [Pubmed]
  26. Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice. Korpi, E.R., Koikkalainen, P., Vekovischeva, O.Y., Mäkelä, R., Kleinz, R., Uusi-Oukari, M., Wisden, W. Eur. J. Neurosci. (1999) [Pubmed]
  27. Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse. Dawson, P.A., Steane, S.E., Markovich, D. Behav. Brain Res. (2004) [Pubmed]
  28. Hyperactivity, neuromotor defects, and impaired learning and memory in a mouse model for metachromatic leukodystrophy. D'Hooge, R., Van Dam, D., Franck, F., Gieselmann, V., De Deyn, P.P. Brain Res. (2001) [Pubmed]
  29. Sedation and need-free salt intake in rats treated with clonidine. De Luca, L.A., Nunes de Souza, R.L., Yada, M.M., Meyer, E.W. Pharmacol. Biochem. Behav. (1999) [Pubmed]
  30. Acetone potentiation and influence on the reversibility of 2,5-hexanedione-induced neurotoxicity studied with behavioural and morphometric methods in rats. Ladefoged, O., Roswall, K., Larsen, J.J. Pharmacol. Toxicol. (1994) [Pubmed]
  31. Impairment of motor coordination induced by doxorubicin in mice. Tubaro, A., Decorti, G., Zilli, C., Bartoli Klugmann, F., Della Loggia, R., Mallardi, F., Grill, V. Pharmacological research communications. (1985) [Pubmed]
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