Disease relevance of Rotarod Performance Test

• Body weight and motor performance on the rotarod test were significantly improved in creatine-supplemented R6/2 mice, whereas the onset of diabetes was markedly delayed [1].
• CGP35024 was seven times more potent against neuropathic hyperalgesia than in the rotarod test for motor co-ordination, whilst L-baclofen was approximately equipotent in the two tests [2].
• Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test [3].
• Baclofen but not scopolamine induced motor incoordination in the rotarod test [4].
• The rotarod test therefore appears to be a good method of quantifying behavioral changes in GAD mice and to be applicable both to objective selection of GAD mice before 8 weeks of age and to evaluation of drugs to treat ataxia or paresis [5].

Psychiatry related information on Rotarod Performance Test

• CRA1000 and CRA1001 had no effects on the hexobarbital-induced anesthesia in mice, the rotarod test in mice, the spontaneous locomotor activity in mice, and a passive avoidance task in rats [6].
• TD50s are usually determined by tests, such as the rotarod test or the chimney test, for quantification of 'minimal neurological deficit', such as motor impairment, while median effective doses are commonly determined in the maximal electroshock seizure (MES) test or the s.c. pentylenetetrazol (PTZ) seizure test in mice or rats [7].
• The effects of postnatal chronic exposure to this methylxanthine on motor skills and locomotor activity were studied with a battery of motor and behavioral tests (negative geotaxis test, wire mesh ascending test, jumping down with a choice test, bar holding test, rotarod test and open field test) in rats during development [8].

High impact information on Rotarod Performance Test

• We show here that exactly how the rotarod test is performed can markedly alter the apparent patterns of genetic influence both in undrugged performance and sensitivity to ethanol intoxication [9].
• There is a good correlation between the apparent affinities of a series of phencyclidine analogs for the phencyclidine receptor and the pharacological activities of these analogs as measured by the rotarod assay [10].
• CT-1 delayed the onset of motor impairment as assessed in the rotarod test [11].
• These effects were antagonized by prior injection of the alpha(2)-adrenoceptor antagonist idazoxan (0.5 mg/kg i.v.), but not the opioid receptor antagonist naloxone (0.1 mg/kg i.v.). On the other hand, cizolirtine (10 mg/kg p.o.) produced no motor deficits in animals using the rotarod test [12].
• In summary, ABT-594 is less potent than (+)-epibatidine in assays of acute and persistent pain and in the rotarod assay [13].

Chemical compound and disease context of Rotarod Performance Test

• Sendide was without effect on motor performance as measured by the rotarod test, while motor incoordination was elicited only 2 min after intrathecal injection of CP-96,345 [14].
• Various combinations of carbamazepine (CAS 298-46-4), felbamate (CAS 25451-15-4), and phenytoin (CAS 57-41-0) were evaluated in mice (i.p.) for anticonvulsant activity (maximal electroshock seizure test) and minimal neurotoxicity (rotarod test) [15].
• In rats exposed for 3 or 6 months to toluene, m-xylene and their mixtures (1:1) at concentrations of 1000 ppm and 100 ppm, respectively, the observed disturbances in rotarod performance test and decrease in spontaneous motor activity were statistically significant in comparison to control [16].
• Spontaneous motor activity, rotarod test and observational rating of sedation were employed to study effect of nifedipine on sedation produced by reserpine, clonidine and propranolol [17].

Anatomical context of Rotarod Performance Test

• The amphetamine-induced rotation test, the cylinder and the rotarod test were most sensitive and reliable in detecting loss of tyrosine hydroxylase-immunoreactive cells in the substantia nigra [18].

Associations of Rotarod Performance Test with chemical compounds

• Full recovery from anaesthesia induced by Saffan 2 ml/kg i.p., as assessed by the rotarod test, occurred after 28.78 +/- 0.86 min [19].
• Gabapentin at 100 mg/kg but not at 30 mg/kg produced motor deficits in animals using the rotarod test [20].
• Preliminary testing of the isomers in the mouse rotarod assay indicates that the trans isomer (1b) is only slightly more active then the cis isomer (1a) [21].
• METHODS: The action of diazepam (0.5-3 mg/kg i.p.) was studied in the elevated plus-maze model of anxiety and rotarod test using mice lacking CCK2 receptors [22].
• Neurotoxic activities were examined with the rotarod test and traction test [23].

Gene context of Rotarod Performance Test

• RESULTS: Motor co-ordination was significantly impaired in the rotarod test of CCK2R receptor-deficient mice [24].
• Lis1 mutant mice displayed abnormal hindpaw clutching responses and were impaired on a rotarod test [25].
• On the rotarod test, however, the mutant mice were significantly more impaired by diazepam (5-20 mg/kg, i.p.), when compared with alpha 6 +/+ control and background C57BL/6J and 129/SvJ mouse lines [26].
• There were no significant differences between Nas1-/- and Nas1+/+ mice in a rotarod performance test of motor coordination and in the forced swim test assessing (anti-)depressant-like behaviours [27].
• Motor coordination and equilibrium, as tested in the rotarod test, was impaired in 12-month-old ASA-deficient mice [28].

Analytical, diagnostic and therapeutic context of Rotarod Performance Test

• The effect of intraperitoneal injection of clonidine (9-72 microg/kg) on need-free 1.5% NaCl intake and on performance (defined as percent of a complete trial) in the rotarod test, was studied in normovolemic adult male rats [29].
• Reversibility of the effect on ambulation was complete within the recovery period, but the effects on rearing and balance in the rotarod test were only reversible within the 10 weeks in the 2,5-hexanedione-treated rats and not in the combined 2,5-hexanedione and acetone-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)[30]
• The neurotoxic effects of a single intraperitoneal or intravenous injection of doxorubicin were evaluated in CD1 mice by means of the rotarod test [31].

References