Disease relevance of Somnambulism

• A significant effect of flurazepam on sleepwalking, sleep-talking, bruxism, sleep terror and excessive movement during sleep, was observed [1].

Psychiatry related information on Somnambulism

• Successful treatment of night terrors and somnambulism with paroxetine [2].
• The parasomnias, including pavor nocturnus and somnambulism, are frequently mistaken for epilepsy, since these nocturnal episodes are paroxysmal in nature, may be associated with automatic behavioral mannerisms, and tend to be recurrent [3].
• A case is reported of a patient treated with bupropion as a smoking cessation medication, who developed somnambulism during nicotine withdrawal [4].

High impact information on Somnambulism

• Family and personal histories did not show epilepsy, psychiatric disorders, or (with 1 exception) previous somnambulism [5].
• HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder [6].
• Clonazepam in the treatment of neuroleptic-induced somnambulism [7].
• Nocturnal paroxysmal dystonia and nocturnal wandering [8].
• In the 7 patients tried on 1 or more treatment regimens, clonazepam effectively suppressed the somnambulism in 5 of 6 patients in whom it was tried, carbamazepine in 1 of 3, flurazepam in 2 of 2, and a combination of clonazepam and phenytoin in one [9].

Chemical compound and disease context of Somnambulism

• Sleepwalking associated with zolpidem [10].
• Treatment of coexistent night-terrors and somnambulism in adults with imipramine and diazepam [11].
• Paroxetine-induced somnambulism [12].
• Side effects involving agitation, e.g., sleepwalking, anger, and panic, were observed in 10 insomniac patients treated with temazepam or triazolam but not other benzodiazepines [13].
• Attempted strangulation during phenothiazine-induced sleep-walking and night terrors [14].

Biological context of Somnambulism

• Sexual behavior in sleep, sleepwalking and possible REM behavior disorder: a case report [15].

Anatomical context of Somnambulism

• The gamma-aminobutyric acid (GABA)B receptor antagonists 2-OH-saclofen and CGP 35348 were injected in the thalamus of freely moving cats via a microdialysis probe while recording the sleep-walking cycle [16].
• Although controversial, episodic nocturnal wandering (ENW) is thought to be a rare and atypical form of nocturnal epilepsy, originating in the frontal lobe and responsive to antiepileptic drugs (AEDs) [17].

Gene context of Somnambulism

• The nocturnal wandering may have started from NREM sleep or REM sleep, and violence was observed in both of these sleep states [18].
• A 51-year-old man with Machado-Joseph disease had a 3-year history of prolonged confusion following nightly nocturnal wandering [19].
• During the nasal CPAP trial, two episodes of sleepwalking were observed during a period of delta sleep rebound [20].
• Study of the 5-HT2 antagonist ritanserin on sleep-walking cycle in the rat [21].
• From somnambulism to the archetypes: the French roots of Jung's split with Freud [22].

References