Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Cefoselis (6R,7R)-3-[[3-amino-2-(2...

Synonyms: CHEMBL2105940, FT-0689997, AC1NX919

This record was replaced with 5748846.

Ohtaki, K. et al., Yamazaki, S. et al.

Yamazaki, Mochizuki, Terai, Sugimoto, Uchida, Matsuoka, Mutoh,

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Disease relevance of Cefoselis

However, the additional factor, such as decrease in brain function related to aging, would be involved in seizures in patient received cefoselis, because an extremely high dose was required to induce seizures even in renal failure rats [1].

High impact information on Cefoselis

In this study, we examined the BBB penetration of cefoselis in normal and renal failure rats by means of brain microdialysis [1].
Cefoselis was dose-dependently appeared in brain extracellular fluid in proportion to its blood level [1].
When cefoselis was injected into the lateral ventricle of the mouse brain at doses higher than 20 microg/animal, it produced convulsions dose-dependently [2].

References

Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. Ohtaki, K., Matsubara, K., Fujimaru, S., Shimizu, K., Awaya, T., Suno, M., Chiba, K., Hayase, N., Shiono, H. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors. Yamazaki, S., Mochizuki, Y., Terai, T., Sugimoto, M., Uchida, I., Matsuoka, N., Mutoh, S. Pharmacol. Biochem. Behav. (2002) [Pubmed]

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