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Chemical Compound Review

Cefoselis     (6R,7R)-3-[[3-amino-2-(2...

Synonyms: CHEMBL2105940, FT-0689997, AC1NX919
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Disease relevance of Cefoselis

  • However, the additional factor, such as decrease in brain function related to aging, would be involved in seizures in patient received cefoselis, because an extremely high dose was required to induce seizures even in renal failure rats [1].

High impact information on Cefoselis


  1. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. Ohtaki, K., Matsubara, K., Fujimaru, S., Shimizu, K., Awaya, T., Suno, M., Chiba, K., Hayase, N., Shiono, H. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
  2. Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors. Yamazaki, S., Mochizuki, Y., Terai, T., Sugimoto, M., Uchida, I., Matsuoka, N., Mutoh, S. Pharmacol. Biochem. Behav. (2002) [Pubmed]
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