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MeSH Review

Lateral Ventricles

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Disease relevance of Lateral Ventricles


Psychiatry related information on Lateral Ventricles


High impact information on Lateral Ventricles

  • Disruption of human neural precursor proliferation can give rise to a small brain (microcephaly), and failure of neurons to migrate properly can lead to an abnormal arrest of cerebral cortical neurons in proliferative zones near the lateral ventricles (periventricular heterotopia) [11].
  • To determine whether MCH is involved in the regulation of feeding, we injected MCH into the lateral ventricles of rats and found that their food consumption increased [12].
  • In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons [13].
  • Two micrograms of prostaglandin E2 injected into the lateral ventricle of the brain in rats had the same anorectic and gastrointestinal motor effect as central administration of 0.02 unit of calcitonin [14].
  • Drinking in response to infusion of angiotensin II into the lateral ventricle was not diminished by aqueduct obstruction [15].

Chemical compound and disease context of Lateral Ventricles


Biological context of Lateral Ventricles


Anatomical context of Lateral Ventricles


Associations of Lateral Ventricles with chemical compounds


Gene context of Lateral Ventricles

  • BDNF, NGF, or vehicle solutions were infused continuously in adult female rats either into the lateral ventricle (intracerebroventricularly) or directly into the septum for 2 weeks beginning at the time of the transection [36].
  • After 8-10 days of recovery, either 10 microliters CRF (5 micrograms) or vehicle solution was injected into the lateral ventricle over a 2-min period [37].
  • Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression [38].
  • The effects of long-term corticotropin-releasing hormone (CRH) infusion in the lateral ventricle of the rat on hypothalamic-pituitary-adrenocortical (HPA) axis parameters and on the immune system function were studied [39].
  • In orchiectomized rats, recombinant rat IL-1 alpha and IL-1 beta administered into the lateral ventricles almost equipotently suppressed plasma LH levels [40].

Analytical, diagnostic and therapeutic context of Lateral Ventricles


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  4. Intraventricular administration of recombinant adenovirus to neonatal twitcher mouse leads to clinicopathological improvements. Shen, J.S., Watabe, K., Ohashi, T., Eto, Y. Gene Ther. (2001) [Pubmed]
  5. Ependymal denudation, aqueductal obliteration and hydrocephalus after a single injection of neuraminidase into the lateral ventricle of adult rats. Grondona, J.M., Pérez-Martín, M., Cifuentes, M., Pérez, J., Jiménez, A.J., Pérez-Fígares, J.M., Fernández-Llebrez, P. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
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  8. Large CSF volume not attributable to ventricular volume in schizotypal personality disorder. Dickey, C.C., Shenton, M.E., Hirayasu, Y., Fischer, I., Voglmaier, M.M., Niznikiewicz, M.A., Seidman, L.J., Fraone, S., McCarley, R.W. The American journal of psychiatry. (2000) [Pubmed]
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  11. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Sheen, V.L., Ganesh, V.S., Topcu, M., Sebire, G., Bodell, A., Hill, R.S., Grant, P.E., Shugart, Y.Y., Imitola, J., Khoury, S.J., Guerrini, R., Walsh, C.A. Nat. Genet. (2004) [Pubmed]
  12. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Qu, D., Ludwig, D.S., Gammeltoft, S., Piper, M., Pelleymounter, M.A., Cullen, M.J., Mathes, W.F., Przypek, R., Kanarek, R., Maratos-Flier, E. Nature (1996) [Pubmed]
  13. Chain migration of neuronal precursors. Lois, C., García-Verdugo, J.M., Alvarez-Buylla, A. Science (1996) [Pubmed]
  14. Prostaglandin E2: a neuromodulator in the central control of gastrointestinal motility and feeding behavior by calcitonin. Fargeas, M.J., Fioramonti, J., Buéno, L. Science (1984) [Pubmed]
  15. Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Ritter, R.C., Slusser, P.G., Stone, S. Science (1981) [Pubmed]
  16. Analysis of ceftriaxone and ceftazidime distribution in cerebrospinal fluid of and cerebral extracellular space in awake rats by in vivo microdialysis. Granero, L., Santiago, M., Cano, J., Machado, A., Peris, J.E. Antimicrob. Agents Chemother. (1995) [Pubmed]
  17. Insulin/hypoglycemia-induced adrenocorticotropin and beta-endorphin release: involvement of hypothalamic histaminergic neurons. Kjaer, A., Knigge, U., Madsen, E.L., Søe-Jensen, P., Bach, F.W., Warberg, J. Endocrinology (1993) [Pubmed]
  18. Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Baker, S.A., Baker, K.A., Hagg, T. Eur. J. Neurosci. (2004) [Pubmed]
  19. Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs. Brent, P.J., Johnston, P.A., Chahl, L.A. Neuropharmacology (1988) [Pubmed]
  20. Effects of a histamine synthesis inhibitor and antihistamines on the sexual behavior of female rats. Donoso, A.O., Broitman, S.T. Psychopharmacology (Berl.) (1979) [Pubmed]
  21. Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Conover, J.C., Doetsch, F., Garcia-Verdugo, J.M., Gale, N.W., Yancopoulos, G.D., Alvarez-Buylla, A. Nat. Neurosci. (2000) [Pubmed]
  22. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Mizoguchi, A., Eguchi, N., Kimura, K., Kiyohara, Y., Qu, W.M., Huang, Z.L., Mochizuki, T., Lazarus, M., Kobayashi, T., Kaneko, T., Narumiya, S., Urade, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  23. Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat. Owen-Lynch, P.J., Draper, C.E., Mashayekhi, F., Bannister, C.M., Miyan, J.A. Brain (2003) [Pubmed]
  24. Central effect of intravenous phenylephrine on baroreflex control of renal nerves. Imaizumi, T., Brunk, S.D., Gupta, B.N., Thames, M.D. Hypertension (1984) [Pubmed]
  25. Interleukin-1beta and neurogenic control of blood pressure in normal rats and rats with chronic renal failure. Ye, S., Mozayeni, P., Gamburd, M., Zhong, H., Campese, V.M. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  26. p107 regulates neural precursor cells in the mammalian brain. Vanderluit, J.L., Ferguson, K.L., Nikoletopoulou, V., Parker, M., Ruzhynsky, V., Alexson, T., McNamara, S.M., Park, D.S., Rudnicki, M., Slack, R.S. J. Cell Biol. (2004) [Pubmed]
  27. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Onoe, H., Ueno, R., Fujita, I., Nishino, H., Oomura, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  28. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Gotman, J., Grova, C., Bagshaw, A., Kobayashi, E., Aghakhani, Y., Dubeau, F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  29. Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses. Sundar, S.K., Becker, K.J., Cierpial, M.A., Carpenter, M.D., Rankin, L.A., Fleener, S.L., Ritchie, J.C., Simson, P.E., Weiss, J.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  30. Expression of the murine homologue of FMR2 in mouse brain and during development. Chakrabarti, L., Bristulf, J., Foss, G.S., Davies, K.E. Hum. Mol. Genet. (1998) [Pubmed]
  31. Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle. Davis, M., Strachan, D.I., Kass, E. Science (1980) [Pubmed]
  32. Calcium channel activation and self-biting in mice. Jinnah, H.A., Yitta, S., Drew, T., Kim, B.S., Visser, J.E., Rothstein, J.D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  33. Synaptic endings and their postsynaptic targets in neostriatum: synaptic specializations revealed from analysis of serial sections. Groves, P.M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  34. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Saar, K., Mazarati, A.M., Mahlapuu, R., Hallnemo, G., Soomets, U., Kilk, K., Hellberg, S., Pooga, M., Tolf, B.R., Shi, T.S., Hökfelt, T., Wasterlain, C., Bartfai, T., Langel, U. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  35. Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Naruse, Y., Oh-hashi, K., Iijima, N., Naruse, M., Yoshioka, H., Tanaka, M. Mol. Cell. Biol. (2004) [Pubmed]
  36. Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection. Morse, J.K., Wiegand, S.J., Anderson, K., You, Y., Cai, N., Carnahan, J., Miller, J., DiStefano, P.S., Altar, C.A., Lindsay, R.M. J. Neurosci. (1993) [Pubmed]
  37. Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF. Mansi, J.A., Rivest, S., Drolet, G. Endocrinology (1996) [Pubmed]
  38. Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Raposinho, P.D., Pedrazzini, T., White, R.B., Palmiter, R.D., Aubert, M.L. Endocrinology (2004) [Pubmed]
  39. Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression. Labeur, M.S., Arzt, E., Wiegers, G.J., Holsboer, F., Reul, J.M. Endocrinology (1995) [Pubmed]
  40. Roles of interleukin-1 alpha and -1 beta in endotoxin-induced suppression of plasma gonadotropin levels in rats. Ebisui, O., Fukata, J., Tominaga, T., Murakami, N., Kobayashi, H., Segawa, H., Muro, S., Naito, Y., Nakai, Y., Masui, Y. Endocrinology (1992) [Pubmed]
  41. Centrally infused bradykinin increases baroreceptor reflex sensitivity. Gerken, V.M., Santos, R.A. Hypertension (1992) [Pubmed]
  42. Dopamine sulfate in ventricular cerebrospinal fluid and motor function in Parkinson's disease. Cedarbaum, J.M., Olanow, C.W. Neurology (1991) [Pubmed]
  43. Immobilization induces acute nitric oxide production in the rat hypothalamus: a role of ionotropic glutamate receptors in the paraventricular nucleus. Shirakawa, T., Mitome, M., Kikuiri, T., Nakamura, W., Oshima, S., Hasegawa, T., Shindoh, M., Oguchi, H. Endocrinology (2004) [Pubmed]
  44. Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain. Bhongsatiern, J., Ohtsuki, S., Tachikawa, M., Hori, S., Terasaki, T. J. Neurochem. (2005) [Pubmed]
  45. Dantrolene protects against ischemic, delayed neuronal death in gerbil brain. Zhang, L., Andou, Y., Masuda, S., Mitani, A., Kataoka, K. Neurosci. Lett. (1993) [Pubmed]
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