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MeSH Review

Extracellular Fluid

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Disease relevance of Extracellular Fluid


Psychiatry related information on Extracellular Fluid


High impact information on Extracellular Fluid


Chemical compound and disease context of Extracellular Fluid


Biological context of Extracellular Fluid


Anatomical context of Extracellular Fluid


Associations of Extracellular Fluid with chemical compounds


Gene context of Extracellular Fluid

  • These findings led us to postulate that poor activation of LCAT in interstitial fluid may result from a change in conformation in apoA-I [36].
  • Insulin-like growth factor I and II (IGF-I and IGF-II) associate with specific IGF binding proteins (IGFBPs) present in plasma and extracellular fluids that can modulate the anabolic effects of these peptides [37].
  • We conclude that a form of IGF binding protein that is present in extracellular fluids and is secreted by many types of cells can markedly potentiate the cellular response to IGF-I [38].
  • Thus, NEP maintains low levels of SP in the extracellular fluid under basal conditions and terminates its proinflammatory effects [39].
  • In contrast to IL-1 alpha but similar to TNF, IL-6 was almost entirely secreted into the extracellular fluid [40].

Analytical, diagnostic and therapeutic context of Extracellular Fluid


  1. Fibronectin fragments modulate monocyte VLA-5 expression and monocyte migration. Trial, J., Baughn, R.E., Wygant, J.N., McIntyre, B.W., Birdsall, H.H., Youker, K.A., Evans, A., Entman, M.L., Rossen, R.D. J. Clin. Invest. (1999) [Pubmed]
  2. Role of prostaglandin E1 and copper in angiogenesis. Ziche, M., Jones, J., Gullino, P.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  3. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. Wang, X.Y., Masilamani, S., Nielsen, J., Kwon, T.H., Brooks, H.L., Nielsen, S., Knepper, M.A. J. Clin. Invest. (2001) [Pubmed]
  4. Identification of a macromolecule containing an anticarcinoembryonic antigen-reactive substance and immunoglobulin M in human pancreatic cancer. Harvey, S.R., Van Dusen, L.R., Douglass, H.O., Holyoke, E.D., Chu, T.M. J. Natl. Cancer Inst. (1978) [Pubmed]
  5. Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood. Wollin, A., Navert, H., Bounous, G. Gastroenterology (1981) [Pubmed]
  6. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Weller, R.O., Massey, A., Newman, T.A., Hutchings, M., Kuo, Y.M., Roher, A.E. Am. J. Pathol. (1998) [Pubmed]
  7. Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats. McNay, E.C., Sherwin, R.S. Diabetes (2004) [Pubmed]
  8. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. Hu, Y., Wilson, G.S. J. Neurochem. (1997) [Pubmed]
  9. Pharmacokinetics and pharmacodynamics of methylphenidate enantiomers in rats. Aoyama, T., Kotaki, H., Sawada, Y., Iga, T. Psychopharmacology (Berl.) (1996) [Pubmed]
  10. Hyperactive striatal neurons in symptomatic Huntington R6/2 mice: variations with behavioral state and repeated ascorbate treatment. Rebec, G.V., Conroy, S.K., Barton, S.J. Neuroscience (2006) [Pubmed]
  11. Kinin formation: mechanisms and role in inflammatory disorders. Proud, D., Kaplan, A.P. Annu. Rev. Immunol. (1988) [Pubmed]
  12. Metabolism of 1,25-dihydroxyvitamin D3. Kumar, R. Physiol. Rev. (1984) [Pubmed]
  13. Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor. Björck, L., Akesson, P., Bohus, M., Trojnar, J., Abrahamson, M., Olafsson, I., Grubb, A. Nature (1989) [Pubmed]
  14. Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-alpha. Teixidó, J., Gilmore, R., Lee, D.C., Massagué, J. Nature (1987) [Pubmed]
  15. Sertoli-Leydig cell communication via an LHRH-like factor. Sharpe, R.M., Fraser, H.M., Cooper, I., Rommerts, F.F. Nature (1981) [Pubmed]
  16. Language guiding therapy: the case of dehydration versus volume depletion. Mange, K., Matsuura, D., Cizman, B., Soto, H., Ziyadeh, F.N., Goldfarb, S., Neilson, E.G. Ann. Intern. Med. (1997) [Pubmed]
  17. Renal hypoprostaglandism, hypertension, and type IV renal tubular acidosis reversed by furosemide. Sanjad, S.A., Keenan, B.S., Hill, L.L. Ann. Intern. Med. (1983) [Pubmed]
  18. Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Gorovits, R., Avidan, N., Avisar, N., Shaked, I., Vardimon, L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  19. Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia. Van Wylen, D.G. Circulation (1994) [Pubmed]
  20. Role of adenosine in the maintenance of coronary vasodilation distal to a severe coronary artery stenosis. Observations in conscious domestic swine. Gewirtz, H., Brautigan, D.L., Olsson, R.A., Brown, P., Most, A.S. Circ. Res. (1983) [Pubmed]
  21. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Kovacsovics-Bankowski, M., Rock, K.L. Science (1995) [Pubmed]
  22. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. Schafer, C., Heiss, A., Schwarz, A., Westenfeld, R., Ketteler, M., Floege, J., Muller-Esterl, W., Schinke, T., Jahnen-Dechent, W. J. Clin. Invest. (2003) [Pubmed]
  23. Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration. Ortola, F.V., Ballermann, B.J., Anderson, S., Mendez, R.E., Brenner, B.M. J. Clin. Invest. (1987) [Pubmed]
  24. Human and murine phenotypes associated with defects in cation-chloride cotransport. Delpire, E., Mount, D.B. Annu. Rev. Physiol. (2002) [Pubmed]
  25. Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog. Knabb, R.M., Ely, S.W., Bacchus, A.N., Rubio, R., Berne, R.M. Circ. Res. (1983) [Pubmed]
  26. Spread of synaptic depression mediated by presynaptic cytoplasmic signaling. Cash, S., Zucker, R.S., Poo, M.M. Science (1996) [Pubmed]
  27. Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion. Youker, K., Smith, C.W., Anderson, D.C., Miller, D., Michael, L.H., Rossen, R.D., Entman, M.L. J. Clin. Invest. (1992) [Pubmed]
  28. Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. Stratton, R., Shiwen, X., Martini, G., Holmes, A., Leask, A., Haberberger, T., Martin, G.R., Black, C.M., Abraham, D. J. Clin. Invest. (2001) [Pubmed]
  29. Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Li, V.W., Folkerth, R.D., Watanabe, H., Yu, C., Rupnick, M., Barnes, P., Scott, R.M., Black, P.M., Sallan, S.E., Folkman, J. Lancet (1994) [Pubmed]
  30. Evidence for angiotensin-converting enzyme- and chymase-mediated angiotensin II formation in the interstitial fluid space of the dog heart in vivo. Wei, C.C., Meng, Q.C., Palmer, R., Hageman, G.R., Durand, J., Bradley, W.E., Farrell, D.M., Hankes, G.H., Oparil, S., Dell'Italia, L.J. Circulation (1999) [Pubmed]
  31. A pharmacological approach to the structure of sodium channels in myelinated axons. Ritchie, J.M. Annu. Rev. Neurosci. (1979) [Pubmed]
  32. Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons. Sah, P., Hestrin, S., Nicoll, R.A. Science (1989) [Pubmed]
  33. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Mahley, R.W. Science (1988) [Pubmed]
  34. Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension. Araoye, M.A., Chang, M.Y., Khatri, I.M., Freis, E.D. JAMA (1978) [Pubmed]
  35. Thiol-disulfide interchange in the binding of bence jones proteins to alpha-antitrypsin, prealbumin, and albumin. Laurell, C.B., Thulin, E. J. Exp. Med. (1975) [Pubmed]
  36. Altered epitope expression of human interstitial fluid apolipoprotein A-I reduces its ability to activate lecithin cholesterol acyl transferase. Wong, L., Curtiss, L.K., Huang, J., Mann, C.J., Maldonado, B., Roheim, P.S. J. Clin. Invest. (1992) [Pubmed]
  37. A unique receptor-independent mechanism by which insulinlike growth factor I regulates the availability of insulinlike growth factor binding proteins in normal and transformed human fibroblasts. Conover, C.A. J. Clin. Invest. (1991) [Pubmed]
  38. An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I. Elgin, R.G., Busby, W.H., Clemmons, D.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  39. Neutral endopeptidase (EC terminates colitis by degrading substance P. Sturiale, S., Barbara, G., Qiu, B., Figini, M., Geppetti, P., Gerard, N., Gerard, C., Grady, E.F., Bunnett, N.W., Collins, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  40. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S.C., Dinarello, C.A. Blood (1990) [Pubmed]
  41. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Cirrito, J.R., Yamada, K.A., Finn, M.B., Sloviter, R.S., Bales, K.R., May, P.C., Schoepp, D.D., Paul, S.M., Mennerick, S., Holtzman, D.M. Neuron (2005) [Pubmed]
  42. The influence of the extracellular fluid volume on the tubular reabsorption of uric acid. Weinman, E.J., Eknoyan, G., Suki, W.N. J. Clin. Invest. (1975) [Pubmed]
  43. Renal clearance of pentavalent antimony (sodium stibogluconate). Rees, P.H., Keating, M.I., Kager, P.A., Hockmeyer, W.T. Lancet (1980) [Pubmed]
  44. Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area. Legault, M., Rompré, P.P., Wise, R.A. J. Neurosci. (2000) [Pubmed]
  45. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Kristjansen, P.E., Boucher, Y., Jain, R.K. Cancer Res. (1993) [Pubmed]
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