Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-00DKJ8 2-dimethylamino-4-methyl- pentanoic acid

Synonyms: AKOS009984901, AC1LB2ED, N,N-Dimethyl-l-leucine, 2-(dimethylamino)-4-methylpentanoic acid, (2S)-2-(dimethylamino)-4-methylpentanoic acid

Gray, K.A. et al., Cheng, Y.C. et al., Bauer, F. et al., Mitch, W.E. et al.

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High impact information on leucine

These data are incorporated into a suggestion that H217 forms part of the binding pocket of the Qi site in a manner reminiscent of the interaction between quinone bound at the Qb site and H190 of the L subunit of the bacterial photosynthetic reaction center [1].
H41 covers L186 of Tip by forming tight hydrophobic contacts, and model calculations suggest that the increase in binding affinity compared with other SH3 domains can mainly be attributed to these additional interactions [2].
In an effort to understand its catalytic mechanism, we constructed plasmids encoding nine different histidine (H)-to-leucine (L) mutants for porcine DNase II and examined the enzyme properties of the expressed mutant proteins [3].
Perfusion of rat hindquarter with KL increased muscle BATase activity; perfusion with acetoacetate, KI, KV, or leu did not [4].

References

Requirement of histidine 217 for ubiquinone reductase activity (Qi site) in the cytochrome bc1 complex. Gray, K.A., Dutton, P.L., Daldal, F. Biochemistry (1994) [Pubmed]
Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity. Bauer, F., Schweimer, K., Meiselbach, H., Hoffmann, S., Rösch, P., Sticht, H. Protein Sci. (2005) [Pubmed]
Identification of three crucial histidine residues (His115, His132 and His297) in porcine deoxyribonuclease II. Cheng, Y.C., Hsueh, C.C., Lu, S.C., Liao, T.H. Biochem. J. (2006) [Pubmed]
alpha-Ketoisocaproate stimulates branched-chain amino acid transaminase in kidney and muscle. Mitch, W.E., Chan, W. Am. J. Physiol. (1979) [Pubmed]

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