Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

LETRAZURIL 2-[2,6-dichloro-4-(3,5-dioxo- 1,2,4-triazin...

Synonyms: Letrazurilo, Letrazurilum, SureCN466345, CHEMBL2104819, AC1L1RUW, ...

Harris, M. et al., Blanshard, C. et al., Hamour, A.A. et al., Victor, G.H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LETRAZURIL

A phase I study of letrazuril in AIDS-related cryptosporidiosis [1].
CONCLUSION: The combination of paromomycin and letrazuril should be considered in the treatment of AIDS-related sclerosing cholangitis [2].
MAIN OUTCOME MEASURES: Response to letrazuril was assessed by eradication of Cryptosporidial oocysts from the stool and symptomatic improvement in diarrhoea and abdominal pain [1].
Open studies of the use of azithromycin, letrazuril and paromomycin in patients with acquired immunodeficiency syndrome (AIDS) and confirmed cryptosporidial diarrhoea for at least a month [3].

High impact information on LETRAZURIL

(The fifteenth evaluable patient had a CD4 count 235 x 10(6)/l.) Of these 14 patients, five showed a major response (symptomatic improvement and eradication of Cryptosporidial oocysts from the stool), two had a minor response (symptomatic improvement with persistence of oocysts in stool), and seven had no response to therapy with letrazuril [1].
Letrazuril therapy for cryptosporidiosis: clinical response and pharmacokinetics [4].
Letrazuril 150-200 mg daily was associated with an improvement in symptoms in 40% of patients treated and cessation of excretion of cryptosporidial oocysts in the stool in 70%; however biopsies remained positive [3].

References

A phase I study of letrazuril in AIDS-related cryptosporidiosis. Harris, M., Deutsch, G., MacLean, J.D., Tsoukas, C.M. AIDS (1994) [Pubmed]
Successful treatment of AIDS-related cryptosporidial sclerosing cholangitis. Hamour, A.A., Bonnington, A., Hawthorne, B., Wilkins, E.G. AIDS (1993) [Pubmed]
Pilot studies of azithromycin, letrazuril and paromomycin in the treatment of cryptosporidiosis. Blanshard, C., Shanson, D.C., Gazzard, B.G. International journal of STD & AIDS. (1997) [Pubmed]
Letrazuril therapy for cryptosporidiosis: clinical response and pharmacokinetics. Victor, G.H., Conway, B., Hawley-Foss, N.C., Manion, D., Sahai, J. AIDS (1993) [Pubmed]

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