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MeSH Review

Abdominal Pain

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Disease relevance of Abdominal Pain

  • Variegate porphyria (VP), a low-penetrant autosomal dominant inherited disorder of haem metabolism, is characterised by photosensitivity (Fig. 1) and a propensity to develop acute neuropsychiatric attacks with abdominal pain, vomiting, constipation, tachycardia, hypertension, psychiatric symptoms and, in the worst cases, quadriplegia [1].
  • Ingestion of a large dose of the milk sugar lactose--for example, the 50-g load in 1 liter of milk--causes symptoms such as abdominal pain, diarrhea, bloating, and flatulence in the majority of people with lactose malabsorption [2].
  • The patients in the nicotine group had greater improvement in the global clinical grade of colitis (P < 0.001) and the histologic grade (P = 0.03), lower stool frequency (a difference of 1.6 stools daily; P = 0.008), less abdominal pain (P = 0.05), and less fecal urgency (P = 0.009) [3].
  • Resistance to ceftriaxone and the fluoroquinolones, which are used to treat invasive salmonella infections, is rare in the United States. We analyzed the molecular characteristics of a ceftriaxone-resistant strain of Salmonella enterica serotype typhimurium isolated from a 12-year-old boy with fever, abdominal pain, and diarrhea [4].
  • Corpus luteum hemorrhage. Cause of acute abdominal pain in patients receiving anticoagulant therapy [5].

Psychiatry related information on Abdominal Pain

  • Penicillin was shown to reduce fever and relieve sore throat, dysphagia, headache, abdominal pain, lethargy and anorexia significantly beyond that achieved with aspirin or acetaminophen alone [6].
  • By the second visit, the T group reported taking medications to achieve regularity less often (P = 0.0269), straining less often (P = 0.0210), having pain with bowel movement (BM) less often (P = 0.0116), and having crampy abdominal pain less often (P = 0.123) than the C group [7].
  • The clinical features are numerous and include headache, fatigue, dizziness, confusion, memory loss, paraesthesia, chest pain, abdominal pain, nausea, and diarrhoea as well as coma, convulsions and death [8].

High impact information on Abdominal Pain


Chemical compound and disease context of Abdominal Pain


Biological context of Abdominal Pain


Anatomical context of Abdominal Pain


Gene context of Abdominal Pain


Analytical, diagnostic and therapeutic context of Abdominal Pain

  • Bleeding from corpus luteum should be considered in differential diagnosis of low abdominal pain in women of reproductive age receiving anticoagulant therapy [5].
  • In 1983, 949 cases of acute non-fatal illness consisting of headache, dizziness, blurred vision, abdominal pain, myalgia, and fainting occurred in the West Bank. Physical examination and biochemical tests were otherwise normal [34].
  • METHODS: Enzyme immunoassay was applied to determine I-FABP levels in the sera of 96 subjects: 13 preoperative patients with ischemic bowel diseases (5 cases of mesenteric infarction and 8 cases of strangulated obstruction of the small bowel), 35 healthy subjects, and 48 hospitalized patients with acute abdominal pain [35].
  • The diagnostic triad of multiple episodes of abdominal pain with elevated serum amylase and identification of the anomaly by ERCP was present uniformly [36].
  • To model a process of functional abdominal pain in females we studied the time course and estrogen dependency of a hyperalgesic state induced by ovariectomy in adult mice [37].


  1. A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria. Meissner, P.N., Dailey, T.A., Hift, R.J., Ziman, M., Corrigall, A.V., Roberts, A.G., Meissner, D.M., Kirsch, R.E., Dailey, H.A. Nat. Genet. (1996) [Pubmed]
  2. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. Suarez, F.L., Savaiano, D.A., Levitt, M.D. N. Engl. J. Med. (1995) [Pubmed]
  3. Transdermal nicotine for active ulcerative colitis. Pullan, R.D., Rhodes, J., Ganesh, S., Mani, V., Morris, J.S., Williams, G.T., Newcombe, R.G., Russell, M.A., Feyerabend, C., Thomas, G.A. N. Engl. J. Med. (1994) [Pubmed]
  4. Ceftriaxone-resistant salmonella infection acquired by a child from cattle. Fey, P.D., Safranek, T.J., Rupp, M.E., Dunne, E.F., Ribot, E., Iwen, P.C., Bradford, P.A., Angulo, F.J., Hinrichs, S.H. N. Engl. J. Med. (2000) [Pubmed]
  5. Corpus luteum hemorrhage. Cause of acute abdominal pain in patients receiving anticoagulant therapy. Waxman, M., Baird, G.J. JAMA (1978) [Pubmed]
  6. Adverse and beneficial effects of immediate treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin. Pichichero, M.E., Disney, F.A., Talpey, W.B., Green, J.L., Francis, A.B., Roghmann, K.J., Hoekelman, R.A. Pediatr. Infect. Dis. J. (1987) [Pubmed]
  7. The effect of dietary fiber on bowel function following radical hysterectomy: a randomized trial. Griffenberg, L., Morris, M., Atkinson, N., Levenback, C. Gynecol. Oncol. (1997) [Pubmed]
  8. Management of the moribund carbon monoxide victim. Thomson, L.F., Mardel, S.N., Jack, A., Shields, T.G. Archives of emergency medicine. (1992) [Pubmed]
  9. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. Hawkey, C.J., Karrasch, J.A., Szczepañski, L., Walker, D.G., Barkun, A., Swannell, A.J., Yeomans, N.D. N. Engl. J. Med. (1998) [Pubmed]
  10. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group. Cavallini, G., Tittobello, A., Frulloni, L., Masci, E., Mariana, A., Di Francesco, V. N. Engl. J. Med. (1996) [Pubmed]
  11. Acute fluoride poisoning from a public water system. Gessner, B.D., Beller, M., Middaugh, J.P., Whitford, G.M. N. Engl. J. Med. (1994) [Pubmed]
  12. Abdominal pain after taking ursodiol. Pratt, D.S., Kaplan, M.M. N. Engl. J. Med. (1993) [Pubmed]
  13. Voluntary interruption of pregnancy with mifepristone (RU 486) and a prostaglandin analogue. A large-scale French experience. Silvestre, L., Dubois, C., Renault, M., Rezvani, Y., Baulieu, E.E., Ulmann, A. N. Engl. J. Med. (1990) [Pubmed]
  14. Recurrent abdominal pain of childhood due to lactose intolerance. Barr, R.G., Levine, M.D., Watkins, J.B. N. Engl. J. Med. (1979) [Pubmed]
  15. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children. Schaad, U.B., Suter, S., Gianella-Borradori, A., Pfenninger, J., Auckenthaler, R., Bernath, O., Cheseaux, J.J., Wedgwood, J. N. Engl. J. Med. (1990) [Pubmed]
  16. Abdominal pain in diabetic metabolic decompensation. Clinical significance. Campbell, I.W., Duncan, L.J., Innes, J.A., MacCuish, A.C., Munro, J.F. JAMA (1975) [Pubmed]
  17. Erythromycin ethylsuccinate-induced cholestasis. Viteri, A.L., Greene, J.F., Dyck, W.P. Gastroenterology (1979) [Pubmed]
  18. Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison. Emery, P., Zeidler, H., Kvien, T.K., Guslandi, M., Naudin, R., Stead, H., Verburg, K.M., Isakson, P.C., Hubbard, R.C., Geis, G.S. Lancet (1999) [Pubmed]
  19. Gastrointestinal motor effects of erythromycin in humans. Sarna, S.K., Soergel, K.H., Koch, T.R., Stone, J.E., Wood, C.M., Ryan, R.P., Arndorfer, R.C., Cavanaugh, J.H., Nellans, H.N., Lee, M.B. Gastroenterology (1991) [Pubmed]
  20. PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial. Voskuijl, W., de Lorijn, F., Verwijs, W., Hogeman, P., Heijmans, J., Mäkel, W., Taminiau, J., Benninga, M. Gut (2004) [Pubmed]
  21. Incidence of familial Mediterranean fever (FMF) mutations among children of Mediterranean extraction with functional abdominal pain. Brik, R., Litmanovitz, D., Berkowitz, D., Shamir, R., Rosenthal, E., Shinawi, M., Gershoni-Baruch, R. J. Pediatr. (2001) [Pubmed]
  22. Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients. Buckley, R.G., King, K.J., Disney, J.D., Riffenburgh, R.H., Gorman, J.D., Klausen, J.H. Annals of emergency medicine. (2000) [Pubmed]
  23. A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain. Kiso, T., Ito, H., Miyata, K., Kamato, T., Naitoh, Y., Iwaoka, K., Yamaguchi, T. Eur. J. Pharmacol. (2001) [Pubmed]
  24. Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Palmer, K.R., Corbett, C.L., Holdsworth, C.D. Gastroenterology (1980) [Pubmed]
  25. A phase I study of letrazuril in AIDS-related cryptosporidiosis. Harris, M., Deutsch, G., MacLean, J.D., Tsoukas, C.M. AIDS (1994) [Pubmed]
  26. Risk of early surgery for Crohn's disease: implications for early treatment strategies. Sands, B.E., Arsenault, J.E., Rosen, M.J., Alsahli, M., Bailen, L., Banks, P., Bensen, S., Bousvaros, A., Cave, D., Cooley, J.S., Cooper, H.L., Edwards, S.T., Farrell, R.J., Griffin, M.J., Hay, D.W., John, A., Lidofsky, S., Olans, L.B., Peppercorn, M.A., Rothstein, R.I., Roy, M.A., Saletta, M.J., Shah, S.A., Warner, A.S., Wolf, J.L., Vecchio, J., Winter, H.S., Zawacki, J.K. Am. J. Gastroenterol. (2003) [Pubmed]
  27. Histologic spectrum of arterial and arteriolar lesions in acute and chronic cocaine-induced mesenteric ischemia: report of three cases and literature review. Hoang, M.P., Lee, E.L., Anand, A. Am. J. Surg. Pathol. (1998) [Pubmed]
  28. Disseminated zoster, hyponatraemia, severe abdominal pain and leukaemia relapse: recognition of a new clinical quartet after bone marrow transplantation. Au, W.Y., Ma, S.Y., Cheng, V.C., Ooi, C.G., Lie, A.K. Br. J. Dermatol. (2003) [Pubmed]
  29. Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. de Jesus, A.R., Silva, A., Santana, L.B., Magalhães, A., de Jesus, A.A., de Almeida, R.P., Rêgo, M.A., Burattini, M.N., Pearce, E.J., Carvalho, E.M. J. Infect. Dis. (2002) [Pubmed]
  30. Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study. Book, L., Hart, A., Black, J., Feolo, M., Zone, J.J., Neuhausen, S.L. Am. J. Med. Genet. (2001) [Pubmed]
  31. Celiac plexus blockade in a 7-year-old child with neuroblastoma. Staats, P.S., Kost-Byerly, S. Journal of pain and symptom management. (1995) [Pubmed]
  32. Elevation of serum interleukin-6 but not serum-soluble interleukin-2 receptor in children with Crohn's disease. Bross, D.A., Leichtner, A.M., Zurakowski, D., Law, T., Bousvaros, A. J. Pediatr. Gastroenterol. Nutr. (1996) [Pubmed]
  33. Association of the -1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome. Pata, C., Erdal, E., Yazc, K., Camdeviren, H., Ozkaya, M., Ulu, O. J. Clin. Gastroenterol. (2004) [Pubmed]
  34. The Arjenyattah epidemic. Home interview data and toxicological aspects. Landrigan, P.J., Miller, B. Lancet (1983) [Pubmed]
  35. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. Kanda, T., Fujii, H., Tani, T., Murakami, H., Suda, T., Sakai, Y., Ono, T., Hatakeyama, K. Gastroenterology (1996) [Pubmed]
  36. Pancreas divisum: is it a surgical disease? Britt, L.G., Samuels, A.D., Johnson, J.W. Ann. Surg. (1983) [Pubmed]
  37. Estrogen-dependent abdominal hyperalgesia induced by ovariectomy in adult mice: a model of functional abdominal pain. Sanoja, R., Cervero, F. Pain (2005) [Pubmed]
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