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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Cryptosporidiosis


High impact information on Cryptosporidiosis


Chemical compound and disease context of Cryptosporidiosis


Biological context of Cryptosporidiosis


Anatomical context of Cryptosporidiosis


Gene context of Cryptosporidiosis

  • Thus C. parvum DHFR may be intrinsically resistant ti inhibition by some antifolate DHFR inhibitors which may explain why cryptosporidiosis is refractory to treatment with the clinically common antibacterial and antiprotozoal antifolates [23].
  • Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis [24].
  • These data suggest that IL-15 is involved in IFN-gamma independent mechanisms of control of human cryptosporidiosis, perhaps via activation of the innate immune response [25].
  • Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1 beta are not key mediators of diarrhea in human cryptosporidiosis [26].
  • Supernatants of CCE-stimulated PBMCs contained interleukin 10 but not interferon gamma (IFN-gamma), while PBMCs from a control (a 2-year-old immunocompetent infant who had recovered from cryptosporidiosis) showed a strong response to IFN-gamma when stimulated with CCE [27].

Analytical, diagnostic and therapeutic context of Cryptosporidiosis


  1. Biliary cryptosporidiosis in HIV-infected people after the waterborne outbreak of cryptosporidiosis in Milwaukee. Vakil, N.B., Schwartz, S.M., Buggy, B.P., Brummitt, C.F., Kherellah, M., Letzer, D.M., Gilson, I.H., Jones, P.G. N. Engl. J. Med. (1996) [Pubmed]
  2. Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. Kelly, P., Jack, D.L., Naeem, A., Mandanda, B., Pollok, R.C., Klein, N.J., Turner, M.W., Farthing, M.J. Gastroenterology (2000) [Pubmed]
  3. Epidemiologic differences between cyclosporiasis and cryptosporidiosis in Peruvian children. Bern, C., Ortega, Y., Checkley, W., Roberts, J.M., Lescano, A.G., Cabrera, L., Verastegui, M., Black, R.E., Sterling, C., Gilman, R.H. Emerging Infect. Dis. (2002) [Pubmed]
  4. The epidemiology of intestinal microsporidiosis in patients with HIV/AIDS in Lima, Peru. Bern, C., Kawai, V., Vargas, D., Rabke-Verani, J., Williamson, J., Chavez-Valdez, R., Xiao, L., Sulaiman, I., Vivar, A., Ticona, E., Navincopa, M., Cama, V., Moura, H., Secor, W.E., Visvesvara, G., Gilman, R.H. J. Infect. Dis. (2005) [Pubmed]
  5. Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model. Brasseur, P., Lemeteil, D., Ballet, J.J. Antimicrob. Agents Chemother. (1993) [Pubmed]
  6. Possible effectiveness of clarithromycin and rifabutin for cryptosporidiosis chemoprophylaxis in HIV disease. HIV Outpatient Study (HOPS) Investigators. Holmberg, S.D., Moorman, A.C., Von Bargen, J.C., Palella, F.J., Loveless, M.O., Ward, D.J., Navin, T.R. JAMA (1998) [Pubmed]
  7. Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. Chen, X.M., Huang, B.Q., Splinter, P.L., Cao, H., Zhu, G., McNiven, M.A., LaRusso, N.F. Gastroenterology (2003) [Pubmed]
  8. Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Amadi, B., Mwiya, M., Musuku, J., Watuka, A., Sianongo, S., Ayoub, A., Kelly, P. Lancet (2002) [Pubmed]
  9. Glutamine stimulates prostaglandin-sensitive Na(+)-H+ exchange in experimental porcine cryptosporidiosis. Argenzio, R.A., Rhoads, J.M., Armstrong, M., Gomez, G. Gastroenterology (1994) [Pubmed]
  10. Resolution of intestinal cryptosporidiosis after treatment of AIDS with AZT. Greenberg, R.E., Mir, R., Bank, S., Siegal, F.P. Gastroenterology (1989) [Pubmed]
  11. Treatment of intestinal cryptosporidiosis with zidovudine and SMS 201-995, a somatostatin analog. Nousbaum, J.B., Robaszkiewicz, M., Cauvin, J.M., Garre, M., Gouerou, H. Gastroenterology (1991) [Pubmed]
  12. Treatment of intestinal cryptosporidiosis with spiramycin. Portnoy, D., Whiteside, M.E., Buckley, E., MacLeod, C.L. Ann. Intern. Med. (1984) [Pubmed]
  13. Activity of azithromycin against cryptosporidia in immunosuppressed rats. Rehg, J.E. J. Infect. Dis. (1991) [Pubmed]
  14. Anticryptosporidial prophylactic efficacy of enrofloxacin and paromomycin in chickens. Sréter, T., Széll, Z., Varga, I. J. Parasitol. (2002) [Pubmed]
  15. Cytotoxic T cells in AIDS colonic cryptosporidiosis. Reijasse, D., Patey-Mariaud de Serre, N., Canioni, D., Huerre, M., Haddad, E., Leborgne, M., Blanche, S., Brousse, N. J. Clin. Pathol. (2001) [Pubmed]
  16. Intestinal parasitism in Peruvian children and molecular characterization of Cryptosporidium species. Cordova Paz Soldan, O., Vargas Vásquez, F., Gonzalez Varas, A., Peréz Cordón, G., Velasco Soto, J.R., Sánchez-Moreno, M., Rodríguez Gonzalez, I., Rosales Lombardo, M.J. Parasitol. Res. (2006) [Pubmed]
  17. Response of T lymphocytes from previously infected calves to recombinant Cryptosporidium parvum P23 vaccine antigen. Wyatt, C.R., Lindahl, S., Austin, K., Kapil, S., Branch, J. J. Parasitol. (2005) [Pubmed]
  18. Efficacy of nitazoxanide and paromomycin in biliary tract cryptosporidiosis in an immunosuppressed gerbil model. Baishanbo, A., Gargala, G., Duclos, C., François, A., Rossignol, J.F., Ballet, J.J., Favennec, L. J. Antimicrob. Chemother. (2006) [Pubmed]
  19. Therapeutic efficacy of halofuginone and spiramycin treatment against Cryptosporidium serpentis (Apicomplexa: Cryptosporidiidae) infections in captive snakes. Graczyk, T.K., Cranfield, M.R., Hill, S.L. Parasitol. Res. (1996) [Pubmed]
  20. Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium. Wyatt, C.R., Barrett, W.J., Brackett, E.J., Schaefer, D.A., Riggs, M.W. J. Parasitol. (2002) [Pubmed]
  21. Experimental infection of cats with Tritrichomonas foetus. Gookin, J.L., Levy, M.G., Law, J.M., Papich, M.G., Poore, M.F., Breitschwerdt, E.B. Am. J. Vet. Res. (2001) [Pubmed]
  22. Supplementation with Lactobacillus reuteri or L. acidophilus reduced intestinal shedding of cryptosporidium parvum oocysts in immunodeficient C57BL/6 mice. Alak, J.I., Wolf, B.W., Mdurvwa, E.G., Pimentel-Smith, G.E., Kolavala, S., Abdelrahman, H., Suppiramaniam, V. Cell. Mol. Biol. (Noisy-le-grand) (1999) [Pubmed]
  23. Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum. Vásquez, J.R., Goozé, L., Kim, K., Gut, J., Petersen, C., Nelson, R.G. Mol. Biochem. Parasitol. (1996) [Pubmed]
  24. Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. Alcantara, C.S., Yang, C.H., Steiner, T.S., Barrett, L.J., Lima, A.A., Chappell, C.L., Okhuysen, P.C., White, A.C., Guerrant, R.L. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
  25. Expression of IL-15 and IL-4 in IFN-gamma-independent control of experimental human Cryptosporidium parvum infection. Robinson, P., Okhuysen, P.C., Chappell, C.L., Lewis, D.E., Shahab, I., Lahoti, S., White, A.C. Cytokine (2001) [Pubmed]
  26. Expression of tumor necrosis factor alpha and interleukin 1 beta in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. Robinson, P., Okhuysen, P.C., Chappell, C.L., Lewis, D.E., Shahab, I., Janecki, A., White, A.C. Infect. Immun. (2001) [Pubmed]
  27. Severe, protracted intestinal cryptosporidiosis associated with interferon gamma deficiency: pediatric case report. Gomez Morales, M.A., Ausiello, C.M., Guarino, A., Urbani, F., Spagnuolo, M.I., Pignata, C., Pozio, E. Clin. Infect. Dis. (1996) [Pubmed]
  28. Protective monoclonal antibody defines a circumsporozoite-like glycoprotein exoantigen of Cryptosporidium parvum sporozoites and merozoites. Riggs, M.W., Stone, A.L., Yount, P.A., Langer, R.C., Arrowood, M.J., Bentley, D.L. J. Immunol. (1997) [Pubmed]
  29. Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis. Mead, J.R., You, X., Pharr, J.E., Belenkaya, Y., Arrowood, M.J., Fallon, M.T., Schinazi, R.F. Antimicrob. Agents Chemother. (1995) [Pubmed]
  30. Paromomycin inhibits Cryptosporidium infection of a human enterocyte cell line. Marshall, R.J., Flanigan, T.P. J. Infect. Dis. (1992) [Pubmed]
  31. Microbiological findings about pulmonary cryptosporidiosis in two AIDS patients. Dupont, C., Bougnoux, M.E., Turner, L., Rouveix, E., Dorra, M. J. Clin. Microbiol. (1996) [Pubmed]
  32. Molecular epidemiology of cryptosporidiosis outbreaks and transmission in British Columbia, Canada. Ong, C.S., Eisler, D.L., Goh, S.H., Tomblin, J., Awad-El-Kariem, F.M., Beard, C.B., Xiao, L., Sulaiman, I., Lal, A., Fyfe, M., King, A., Bowie, W.R., Isaac-Renton, J.L. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
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