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MeSH Review

Cryptosporidiosis

 
 
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Disease relevance of Cryptosporidiosis

 

High impact information on Cryptosporidiosis

 

Chemical compound and disease context of Cryptosporidiosis

 

Biological context of Cryptosporidiosis

 

Anatomical context of Cryptosporidiosis

 

Gene context of Cryptosporidiosis

  • Thus C. parvum DHFR may be intrinsically resistant ti inhibition by some antifolate DHFR inhibitors which may explain why cryptosporidiosis is refractory to treatment with the clinically common antibacterial and antiprotozoal antifolates [23].
  • Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis [24].
  • These data suggest that IL-15 is involved in IFN-gamma independent mechanisms of control of human cryptosporidiosis, perhaps via activation of the innate immune response [25].
  • Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1 beta are not key mediators of diarrhea in human cryptosporidiosis [26].
  • Supernatants of CCE-stimulated PBMCs contained interleukin 10 but not interferon gamma (IFN-gamma), while PBMCs from a control (a 2-year-old immunocompetent infant who had recovered from cryptosporidiosis) showed a strong response to IFN-gamma when stimulated with CCE [27].
 

Analytical, diagnostic and therapeutic context of Cryptosporidiosis

References

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  2. Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. Kelly, P., Jack, D.L., Naeem, A., Mandanda, B., Pollok, R.C., Klein, N.J., Turner, M.W., Farthing, M.J. Gastroenterology (2000) [Pubmed]
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  18. Efficacy of nitazoxanide and paromomycin in biliary tract cryptosporidiosis in an immunosuppressed gerbil model. Baishanbo, A., Gargala, G., Duclos, C., François, A., Rossignol, J.F., Ballet, J.J., Favennec, L. J. Antimicrob. Chemother. (2006) [Pubmed]
  19. Therapeutic efficacy of halofuginone and spiramycin treatment against Cryptosporidium serpentis (Apicomplexa: Cryptosporidiidae) infections in captive snakes. Graczyk, T.K., Cranfield, M.R., Hill, S.L. Parasitol. Res. (1996) [Pubmed]
  20. Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium. Wyatt, C.R., Barrett, W.J., Brackett, E.J., Schaefer, D.A., Riggs, M.W. J. Parasitol. (2002) [Pubmed]
  21. Experimental infection of cats with Tritrichomonas foetus. Gookin, J.L., Levy, M.G., Law, J.M., Papich, M.G., Poore, M.F., Breitschwerdt, E.B. Am. J. Vet. Res. (2001) [Pubmed]
  22. Supplementation with Lactobacillus reuteri or L. acidophilus reduced intestinal shedding of cryptosporidium parvum oocysts in immunodeficient C57BL/6 mice. Alak, J.I., Wolf, B.W., Mdurvwa, E.G., Pimentel-Smith, G.E., Kolavala, S., Abdelrahman, H., Suppiramaniam, V. Cell. Mol. Biol. (Noisy-le-grand) (1999) [Pubmed]
  23. Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum. Vásquez, J.R., Goozé, L., Kim, K., Gut, J., Petersen, C., Nelson, R.G. Mol. Biochem. Parasitol. (1996) [Pubmed]
  24. Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. Alcantara, C.S., Yang, C.H., Steiner, T.S., Barrett, L.J., Lima, A.A., Chappell, C.L., Okhuysen, P.C., White, A.C., Guerrant, R.L. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
  25. Expression of IL-15 and IL-4 in IFN-gamma-independent control of experimental human Cryptosporidium parvum infection. Robinson, P., Okhuysen, P.C., Chappell, C.L., Lewis, D.E., Shahab, I., Lahoti, S., White, A.C. Cytokine (2001) [Pubmed]
  26. Expression of tumor necrosis factor alpha and interleukin 1 beta in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. Robinson, P., Okhuysen, P.C., Chappell, C.L., Lewis, D.E., Shahab, I., Janecki, A., White, A.C. Infect. Immun. (2001) [Pubmed]
  27. Severe, protracted intestinal cryptosporidiosis associated with interferon gamma deficiency: pediatric case report. Gomez Morales, M.A., Ausiello, C.M., Guarino, A., Urbani, F., Spagnuolo, M.I., Pignata, C., Pozio, E. Clin. Infect. Dis. (1996) [Pubmed]
  28. Protective monoclonal antibody defines a circumsporozoite-like glycoprotein exoantigen of Cryptosporidium parvum sporozoites and merozoites. Riggs, M.W., Stone, A.L., Yount, P.A., Langer, R.C., Arrowood, M.J., Bentley, D.L. J. Immunol. (1997) [Pubmed]
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  31. Microbiological findings about pulmonary cryptosporidiosis in two AIDS patients. Dupont, C., Bougnoux, M.E., Turner, L., Rouveix, E., Dorra, M. J. Clin. Microbiol. (1996) [Pubmed]
  32. Molecular epidemiology of cryptosporidiosis outbreaks and transmission in British Columbia, Canada. Ong, C.S., Eisler, D.L., Goh, S.H., Tomblin, J., Awad-El-Kariem, F.M., Beard, C.B., Xiao, L., Sulaiman, I., Lal, A., Fyfe, M., King, A., Bowie, W.R., Isaac-Renton, J.L. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
 
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