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Chemical Compound Review:

SureCN928197 N-phenyl-N-[1-(1- phenylpropan-2-yl)-4...

Synonyms: AG-D-87427, AG-H-19584, CHEMBL2022411, AC1L1WTB, AC1Q2RPI, ...

Henderson, G.L. et al., Martin, M. et al., Sternbach, G.L. et al.

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Disease relevance of ALPHA-METHYLFENTANYL

INTERVENTIONS: Emergency physicians became suspicious of China White use after an unusual increase in narcotic overdoses presenting to the ED coupled with "routine drug of abuse" screens negative for opiates despite dramatic patient responses to naloxone [1].

High impact information on ALPHA-METHYLFENTANYL

SETTING: The first outbreak of narcotic overdoses in the eastern United States involving China White occurred in Allegheny County, Pennsylvania, in 1988 [1].
Of the samples, 11 were positive by radioimmunoassay and all were confirmed by GC/MS and found to contain fentanyl, alpha-methylfentanyl, fluorofentanyl, cis- and trans-3-methylfentanyl, thienylfentanyl, or cis- and trans-3-methylthienylfentanyl [2].
"Adam," "Eve," "ecstasy," "China white." Illicit street drugs such as these are called designer drugs because they are designed to elicit certain effects and to bypass legal classification [3].

Analytical, diagnostic and therapeutic context of ALPHA-METHYLFENTANYL

This method was verified by analyzing 18 "China White" samples, first by RIA and then by gas chromatography/mass spectrometry (GC/MS) with the spectrometrist blind to the results of the RIA [2].

References

China White epidemic: an eastern United States emergency department experience. Martin, M., Hecker, J., Clark, R., Frye, J., Jehle, D., Lucid, E.J., Harchelroad, F. Annals of emergency medicine. (1991) [Pubmed]
Rapid screening of fentanyl (China White) powder samples by solid-phase radioimmunoassay. Henderson, G.L., Harkey, M.R., Jones, A.D. Journal of analytical toxicology. (1990) [Pubmed]
'Designer drugs'. Recognizing and managing their toxic effects. Sternbach, G.L., Varon, J. Postgraduate medicine. (1992) [Pubmed]

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